Wilson’s disease in pregnancy: case series and review of literature

BMC Research Notes

Lumaan Sheikh²  Ali Khawaja¹  Ayesha Malik² 

[1] Medical Student, Medical College, The Aga Khan University Hospital, Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan;Department of Obstetrics and Gynecology, The Aga Khan University Hospital, Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan

关键词: Zinc sulphate;    Wilson’s disease;    Pregnancy;    Infertility;    Copper metabolism;   

Others  :  1141326
DOI  :  10.1186/1756-0500-6-421

 received in 2012-11-28, accepted in 2013-10-15,  发布年份 2013

【 摘 要 】

Background

Wilson’s disease is a rare, autosomal recessive inherited disorder characterized by impaired liver metabolism of copper leading to decreased biliary excretion and incorporation of ceruloplasmin levels mainly in the liver and brain. Untreated Wilson’s disease has been shown to cause subfertility and even in cases where pregnancy occurs, it often results in spontaneous miscarriage.

Case presentations

We present four cases of successful pregnancy outcomes in three patients diagnosed with Wilson’s disease along with the literature review. All the patients were managed with zinc sulphate without any postnatal complications.

Conclusion

Patients with Wilson’s disease receiving regular treatment who remain asymptomatic are usually able to conceive and achieve successful outcomes. However, these pregnancies should be considered high risk and merit regular surveillance.

【 授权许可】

   
2013 Malik et al.; licensee BioMed Central Ltd.

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