Effectiveness of a brief psychoeducational group intervention for relatives on the course of disease in patients after inpatient depression treatment compared with treatment as usual – study protocol of a multisite randomised controlled trial

BMC Psychiatry

Lars P. Hölzel¹  Mathias Berger¹  Eva-Maria Bitzer⁴  Klaus Hesse³  Shinji Shimodera²  Ramona Meister⁵  Levente Kriston⁵  Juliette Wilk¹  Fabian Frank⁴ 

[1] Department of Psychiatry and Psychotherapy, Research Group Psychotherapy and Health Services Research, Medical Center – University of Freiburg, Hauptstraße 5, Freiburg, D-79104, Germany;Department of Neuropsychiatry, Kochi Medical School, Kohasu, Okoh-cho, Nankokushi, Kochi 783-8505, Japan;Department of Psychiatry and Psychotherapy, University Medical Center Tübingen, Calwerstraße 14, Tübingen, D-72072, Germany;Department of Public Health and Health Education, University of Education Freiburg, Kunzenweg 21, Freiburg, D-79117, Germany;Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Hamburg, D-20246, Germany

关键词: Randomised controlled trial;    Relatives;    Family intervention;    Psychoeducation;    Depression;   

Others  :  1231587
DOI  :  10.1186/s12888-015-0633-4

 received in 2015-08-20, accepted in 2015-10-02,  发布年份 2015

【 摘 要 】

Background

Relapses and rehospitalisations are common after acute inpatient treatment in depressive disorders. Interventions for stabilising treatment outcomes are urgently needed. Psychoeducational group interventions for relatives were shown to be suitable for improving the course of disease in schizophrenia and bipolar disorders. A small Japanese monocentre randomised controlled trial also showed promising results for depressive disorders. However, the evidence regarding psychoeducation for relatives of patients with depressive disorders is unclear.

Methods/Design

The study is conducted as a two-arm multisite randomised controlled trial to evaluate the incremental effect of a brief psychoeducational group intervention for relatives as a maintenance treatment on the course of disease compared to treatment as usual. Primary outcome is the estimated number of depression-free-days in patients within one year after discharge from inpatient treatment. 180 patients diagnosed with unipolar depressive disorders as well as one key relative per patient will be included during inpatient treatment and randomly allocated to the conditions at discharge. In the intervention group, relatives will participate in a brief psychoeducational group intervention following the patient’s discharge. The intervention consists of four group sessions lasting 90 to 120 min each. Every group session contains informational parts as well as structured training in problem-solving. In both study conditions, patients will receive treatment as usual. Patients as well as relatives will be surveyed by means of questionnaires at discharge and three, six, nine and twelve months after discharge. In addition to the primary outcome, several patient-related and relative-related secondary outcomes will be considered and health economics will be investigated.

Discussion

Our study will provide evidence on the incremental effect of a brief psychoeducational intervention for relatives as a maintenance treatment after inpatient depression treatment. Positive results may have a major impact on health care for depression.

Trial registration

German Clinical Trials Register (DRKS): DRKS00006819; Trial registration date: 2014 Oktober 31; Universal Trial Number (UTN): U1111-1163-5391

【 授权许可】

   
2015 Frank et al.

【 图 表 】

Fig. 1.

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