Sleeping well

BMC Medicine

G Bryan Young¹  Mithu Sen¹ 

[1] Department of Medicine, Division of Critical Care Medicine, Western University, London, Ontario, N6A 5A5, Canada

关键词: circadian rhythm;    actigraphy;    minimally conscious state;    vegetative state;   

Others  :  857215
DOI  :  10.1186/1741-7015-11-19

 received in 2012-12-17, accepted in 2013-01-24,  发布年份 2013

【 摘 要 】

In a study by Cruse et al. published in BMC Medicine, patients with severe brain damage who were in the Vegetative or Minimally Conscious States (VS or MCS, respectively) from traumatic and nontraumatic etiologies had assessments of circadian rhythms using an actigraph, a device worn on a limb to evaluate circadian rhythmicity, in this population. This is a novel approach and is being used as a surrogate for polysomnography and other reference standards. Cruse et al. showed more disruption in circadian rhythms in the VS when compared to the MCS. This suggests that more brain injury occurs in the areas that control circadian rhythmicity in VS than in MCS patients. The study provides opportunities for improved prognostication and rehabilitation strategies in this patient population.

【 授权许可】

   
2013 Sen and Young; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Cruse D, Thibaut A, Demertzi A, Nantes JC, Bruno M-A, Gosseries O, Vanhaudenhuyse A, Nekinschtein TA, Owen AM, Laureys S: Actigraphy assessments of circadian sleep-wake cycles in the vegetative and minimally conscious states. BMC Med, in press.
• [2]Jean-Louis G, von Gizycki H, Zizi F, Spielman A, Hauri P, Taub H: The actigraph data analysis software: I A novel approach to scoring and interpreting sleep-wake activity. Percept Mot Skills 1997, 85:207-216.
• [3]Morgenthaler T, Alessi C, Friedman L, Owens J, Kapur V, Boehlecke B, Brown T, Chesson A Jr, Coleman J, Lee-Chiong T, Pancer J, Swick TJ: Practice parameters for the use of actigraphy in the assessment of sleep and sleep disorders: an update for 2007. Sleep 2007, 30:519-529.
• [4]Schiff ND: Central thalamic contributions to arousal regulation and neurological disorders of consciousness. Ann N Y Acad Sci 2008, 1129:105-118.
• [5]Fernandez-Espejo D, Junque C, Bernabeu M, Roig-Rovira T, Vendrell P, Mercader JM: Reductions in thalamic volume and regional shape changes in the vegetative and the minimally conscious states. J Neurotrauma 2010, 27:1187-1193.
• [6]Owen AM, Coleman MR, Boly M, Davis MH, Laureys S, Pickard JD: Detecting awareness in the vegetative state. Science 2006, 313:1402.
• [7]Cruse D, Chennu S, Chatelle C, Bekinschtein TA, Fernandez-Espero D, Pickard JD, Laureys S, Owen AM: Bedside detection of awareness in the vegetative state - a cohort study. Lancet 2011, 378:2088-2094.
• [8]Mackay LE, Bernstein BA, Chapman PE, Morgan AS, Milazzo LS: Early intervention in severe head injury: long-term benefits of a formalized program. Arch Phys Med Rehabil 1992, 73:635-641.