The effect of perinatal anxiety on bronchiolitis is influenced by polymorphisms in ROS-related genes

BMC Pulmonary Medicine

Soo-Jong Hong^1,10  Yee-Jin Shin⁶  Katherine M Keyes^1,14  Joo-Shil Lee^1,15  Eun-Jin Kim^1,15  So-Yeon Lee^1,13  Hyo-Bin Kim^2,21  Byoung-Ju Kim¹  Ji-Won Kwon^1,16  Ju-Hee Seo⁴  Hyung Young Kim^1,11  Young-Ho Jung^1,10  Song I Yang^1,10  Hye-Sung Won²  Kyung-Ju Lee^1,18  Suk-Joo Choi^1,17  Ja-Young Kwon^1,12  Kang Mo Ahn⁵  Youn Ho Shin⁹  Kyung Won Kim³  Jinah Park^1,19  In Ae Choi⁷  Mi-Jin Kang^1,18  Ho-Sung Yu^1,18  Dong In Suh⁸  Kyung-Sook Lee^1,19  Hyoung Yoon Chang^2,20  Eun Lee^1,10 

[1] Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan, Korea;Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea;Department of Pediatrics, Severance Children’s Hospital, College of Medicine, Yonsei University, Seoul, Korea;Department of Pediatrics, Korea Cancer Center Hospital, Seoul, Korea;Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea;Department of Psychiatry, Gangnam Severance Hospital, Yonsei University College of Medicine, 250 Seongsandong, Seodaemun-gu, Seoul 120-752, Korea;Sewon Infant Child Development Center, Seoul, Korea;Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea;Department of Pediatrics, CHA Medical Center, CHA University School of Medicine, Seoul, Korea;Department of Pediatrics, Childhood Asthma Atopy Center, Research Center for Standardization of Allergic Diseases, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea;Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, Korea;Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea;Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea;Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA;Allergy TF, Department of Immunology and Pathology, Korea National Institute of Health, Cheongwon, Korea;Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea;Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea;Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea;Department of Rehabilitation, Hanshin University, Gyeonggi-do, Korea;Department of Psychiatry, Ajou University College of Medicine, Gyeonggi-do, Korea;Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea

关键词: Respiratory tract infection;    Polymorphism;    Glutathione S-transferase;    Perinatal;    CD14;    Bronchiolitis;    Anxiety;   

Others  :  1092019
DOI  :  10.1186/1471-2466-14-154

 received in 2014-05-13, accepted in 2014-09-23,  发布年份 2014

【 摘 要 】

Background

Exposure to perinatal anxiety affects disease susceptibility in offspring but studies on the association between perinatal anxiety and gene polymorphisms are lacking. This study aimed to elucidate the interaction between perinatal anxiety and polymorphisms in antioxidant defense and innate immunity genes on the development of respiratory tract infections (RTIs) during early infancy.

Methods

Trait anxiety levels in 440 women were assessed by the State-Trait Anxiety Inventory during late gestation. The occurrence of RTIs, including bronchiolitis, during the first year of life was assessed by parent-reported doctor diagnosis. Polymorphisms in glutathione S-transferase P-1 (GSTP1, rs1695) and CD14 (rs2569190) were genotyped using the TaqMan assay. Copy number variations of GSTT1 were measured by real-time polymerase chain reaction.

Results

Exposure to high levels of perinatal anxiety increased the risk of bronchiolitis in the first year of life (adjusted odds ratio [aOR], 1.30; 95% confidence interval [CI]: 1.00–1.80), in particular among children with the AG + GG genotype of GSTP1 or the GSTT1 null genotype (aOR 3.36 and 2.79). In infants with the TC + CC genotype of CD14, high levels of perinatal anxiety were associated with an increased risk of upper RTI, lower RTI, and bronchiolitis (aOR 2.51, 4.60, and 4.31, respectively).

Conclusions

Perinatal maternal anxiety levels affect the occurrence of bronchiolitis in offspring. The effect of perinatal anxiety on the occurrence of bronchiolitis during infancy was influenced by genetic polymorphisms in antioxidant defense and innate immunity genes.

【 授权许可】

   
2014 Lee et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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