期刊论文详细信息
BMC Psychiatry
Ten-year audit of clients presenting to a specialised service for young people experiencing or at increased risk for psychosis
Vaughan J Carr4  Mick Hunter5  Sean A Halpin5  Ulrich Schall2  Ketrina A Sly1  Terry J Lewin3  Agatha M Conrad1 
[1] CTNMH (MH-READ), Hunter New England Mental Health and the University of Newcastle, McAuley Centre, Newcastle NSW 2300, Australia;Psychological Assistance Service, Hunter New England Mental Health, Newcastle NSW 2300, Australia;Schizophrenia Research Institute, Darlinghurst NSW 2010, Sydney, Australia;School of Psychiatry, University of New South Wales, Kensington NSW 2033, Australia;School of Psychology, University of Newcastle, Callaghan NSW 2308, Australia
关键词: Early intervention;    Youth;    Comorbidity;    Service evaluation;    Risk status;    Psychosis;   
Others  :  1092312
DOI  :  10.1186/s12888-014-0318-4
 received in 2014-03-10, accepted in 2014-10-24,  发布年份 2014
PDF
【 摘 要 】

Background

Despite strong research interest in psychosis risk identification and the potential for early intervention, few papers have sought to document the implementation and evaluation of specialised psychosis related services. Assessment of Ultra High Risk (UHR) has been given priority, but it is equally as important to identify appropriate comparison groups and other baseline differences. This largely descriptive service evaluation paper focuses on the ‘baseline characteristics’ of referred clients (i.e., previously assessed characteristics or those identified within the first two months following service presentation).

Methods

Data are reported from a 10-year layered service audit of all presentations to a ‘Psychological Assistance Service’ for young people (PAS, Newcastle, Australia). Baseline socio-demographic and clinical characteristics (N =1,997) are described (including clients’ psychosis and UHR status, previous service contacts, hospitalisation rates, and diagnostic and comorbidity profiles). Key groups are identified and comparisons made between clients who received ongoing treatment and those who were primarily assessed and referred elsewhere.

Results

Clients averaged 19.2 (SD =4.5) years of age and 59% were male. One-tenth of clients (9.6%) were categorised as UHR, among whom there were relatively high rates of attenuated psychotic symptoms (69.1%), comorbid depression (62.3%), anxiety (42.9%), and attentional and related problems (67.5%). Overall, one-fifth (19.8%) experienced a recent psychotic episode, while a further 14.5% were categorised as having an existing psychosis (46.7% with a schizophrenia diagnosis), amongst whom there were relatively high rates of comorbid substance misuse (52.9%), psychosocial (70.2%) and physical health (37.7%) problems. The largest group presenting to PAS were those with non-psychotic disorders (43.7%), who provide a valuable comparison group against which to contrast the health trajectories of those with UHR and recent psychosis. Ongoing treatment by PAS was preferentially given to those experiencing or at risk for psychosis and those reporting greater current distress or dysfunction.

Conclusions

Whether or not UHR clients transition to psychosis, they displayed high rates of comorbid depression and anxiety at service presentation, with half receiving ongoing treatment from PAS. Although international comparisons with similar services are difficult, the socio-demographic and comorbidity patterns observed here were viewed as largely consistent with those reported elsewhere.

【 授权许可】

   
2014 Conrad et al.; licensee BioMed Central Ltd.

【 预 览 】
附件列表
Files Size Format View
20150128182427651.pdf 617KB PDF download
Figure 1. 38KB Image download
【 图 表 】

Figure 1.

【 参考文献 】
  • [1]Yung AR, McGorry PD: The initial prodrome in psychosis: descriptive and qualitative qspects. Aust N Z J Psychiatry 1996, 30:587-599.
  • [2]Yung AR, Phillips LJ, Yuen HP, Francey SM, McFarlane CA, Hallgren M, McGorry PD: Psychosis prediction: 12-month follow up of a high-risk ("prodromal") group. Schizophr Res 2003, 60:21-32.
  • [3]Yung AR, Nelson B, Stanford C, Simmons MB, Cosgrave EM, Killackey E, Phillips LJ, Bechdolf A, Buckby J, McGorry PD: Validation of "prodromal" criteria to detect individuals at ultra high risk of psychosis: 2 year follow-up. Schizophr Res 2008, 105:10-17.
  • [4]Yung AR, Nelson B, Thompson A, Wood SJ: The psychosis threshold in Ultra High Risk (prodromal) research: is it valid? Schizophr Res 2010, 120:1-6.
  • [5]Yung AR: Risk, disorder and diagnosis. Aust N Z J Psychiatry 2011, 45:915-919.
  • [6]Fusar-Poli P, Borgwardt S, Bechdolf A, Addington J, Riecher-Rossler A, Schultze-Lutter F, Keshavan M, Wood S, Ruhrmann S, Seidman LJ, Valmaggia L, Cannon T, Velthorst E, De Haan L, Cornblatt B, Bonoldi I, Birchwood M, McGlashan T, Carpenter W, McGorry P, Klosterkotter J, McGuire P, Yung A: The psychosis high-risk state: a comprehensive state-of-the-art review. JAMA Psychiatry 2013, 70:107-120.
  • [7]Yung AR, Yuen HP, Berger G, Francey S, Hung T-C, Nelson B, Phillips LJ, McGorry PD: Declining transition rate in ultra high risk (prodromal) services: dilution or reduction of risk? Schizophr Bull 2007, 33:673-681.
  • [8]Correll CU, Hauser M, Auther AM, Cornblatt BA: Research in people with psychosis risk syndrome: a review of the current evidence and future directions. J Child Psychol Psychiatry 2010, 51:390-431.
  • [9]Simon AE, Velthorst E, Nieman DH, Linszen D, Umbricht D, de Haan L: Ultra high-risk state for psychosis and non-transition: A systematic review. Schizophr Res 2011, 132:8-17.
  • [10]McGorry PD: Pre-emptive intervention in psychosis: Agnostic rather than diagnostic. Aust N Z J Psychiatry 2011, 45:515-519.
  • [11]Jorm AF: ‘Prodromal diagnosis’ of psychosis: An impartial commentary. Aust N Z J Psychiatry 2011, 45:520-523.
  • [12]Yung AR: Early intervention in psychosis: evidence, evidence gaps, criticism, and confusion. Aust N Z J Psychiatry 2012, 46:7-9.
  • [13]Castle D: The truth, and nothing but the truth, about early intervention in psychosis. Aust N Z J Psychiatry 2012, 46:10-13.
  • [14]McGorry PD: Truth and reality in early intervention. Aust N Z J Psychiatry 2012, 46:313-316.
  • [15]Carr VJ: Time to move on? Commentary on the early intervention in psychosis debate. Aust N Z J Psychiatry 2012, 46:384-385.
  • [16]McGrath JJ: The early intervention debate provides a distraction from another ‘unspeakable truth’. Aust N Z J Psychiatry 2012, 46:681-682.
  • [17]Castle D: What, after all, is the truth: Response to McGorry. Aust N Z J Psychiatry 2012, 46:685-687.
  • [18]Jorm AF: Treatment to reduce risk of psychosis: The need to consider the potential harms as well as the benefits. Aust N Z J Psychiatry 2013, 47:881.
  • [19]Ehlkes T, Michie PT, Schall U: Brain imaging correlates of emerging schizophrenia. Neuropsychiatry 2012, 2:147-154.
  • [20]Tanskanen S, Morant N, Hinton M, Lloyd-Evans B, Crosby M, Killaspy H, Raine R, Pilling S, Johnson S: Service user and carer experiences of seeking help for a first episode of psychosis: a UK qualitative study. BMC Psychiatry 2011, 11:157. BioMed Central Full Text
  • [21]Preti A, Cella M: Randomized-controlled trials in people at ultra high risk of psychosis: a review of treatment effectiveness. Schizophr Res 2010, 123:30-36.
  • [22]Robinson J, Cotton S, Conus P, Schimmelmann BG, McGorry P, Lambert M: Prevalence and predictors of suicide attempt in an incidence cohort of 661 young people with first-episode psychosis. Aust N Z J Psychiatry 2009, 43:149-157.
  • [23]Lui S: Risk factors for deliberate self-harm and completed suicide in young Chinese people with schizophrenia. Aust N Z J Psychiatry 2009, 43:252-259.
  • [24]Larsen T, Melle I, Auestad B, Haahr U, Joa I, Johannessen J, Opjordsmoen S, Rund B, Rossberg J, Simonsen E, Vaglum P, Friis S, McGlashan T: Early detection of psychosis: positive effects on 5-year outcome. Psychol Med 2011, 41:1461-1469.
  • [25]Connor C, Birchwood M, Palmer C, Channa S, Freemantle N, Lester H, Patterson P, Singh S: Don't turn your back on the symptoms of psychosis: a proof-of-principle, quasi-experimental public health trial to reduce the duration of untreated psychosis in Birmingham, UK. BMC Psychiatry 2013, 13:67. BioMed Central Full Text
  • [26]Marshall M, Lewis S, Lockwood A, Drake R, Jones P, Croudace T: Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. Arch Gen Psychiatry 2005, 62:975-983.
  • [27]Malla A, Norman R, Scholten D, Machanda R, Mclean T: A community intervention for the early identification of first episode psychosis impact on duration of untreated psychosis (DUP) and patient characteristics. Soc Psychiatry Psychiatr Epidemiol 2005, 40:337-344.
  • [28]Blanchard JJ, Brown SA, Horan WP, Sherwood AR: Substance use disorders in schizophrenia: Review, integration, and a proposed model. Clin Psychol Rev 2000, 20:207-234.
  • [29]Kavanagh DJ, Waghorn G, Jenner L, Chant DC, Carr V, Evans M, Herrman H, Jablensky A, McGrath JJ: Demographic and clinical correlates of comorbid substance use disorders in psychosis: multivariate analyses from an epidemiological sample. Schizophr Res 2004, 66:115-124.
  • [30]Moore E, Mancuso SG, Slade T, Galletly C, Castle DJ: The impact of alcohol and illicit drugs on people with psychosis: The second Australian national survey of psychosis. Aust N Z J Psychiatry 2012, 46:864-878.
  • [31]Romm KL, Rossberg JI, Berg AO, Hansen CF, Andreassen OA, Melle I: Assessment of social anxiety in first episode psychosis using the Liebowitz Social Anxiety scale as a self-report measure. Eur Psychiatry 2011, 26:115-121.
  • [32]Yung AR, Phillips LJ, Yuen HP, McGorry PD: Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features. Schizophr Res 2004, 67:131-142.
  • [33]Velthorst E, Nieman DH, Becker HE, van de Fliert R, Dingemans PM, Klaassen R, de Haan L, van Amelsvoort T, Linszen DH: Baseline differences in clinical symptomatology between ultra high risk subjects with and without a transition to psychosis. Schizophr Res 2009, 109:60-65.
  • [34]Addington J, Cornblatt B, Cadenhead K, Cannon T, McGlashan T, Perkins D, Seidman L, Tsuang M, Walker E, Woods S, Heinssen R: At clinical high risk for psychosis: Outcome for nonconverters. Am J Psychiatry 2011, 168:800-805.
  • [35]Varghese D, Scott J, Welham J, Bor W, Najman J, O'Callaghan M, Williams G, McGrath J: Psychotic-like experiences in major depression and anxiety disorders: A population-based survey in young adults. Schizophr Bull 2011, 37:389-393.
  • [36]Häfner H, Maurer K, Trendler G, An der Heiden W, Schmidt M: The early course of schizophrenia and depression. Eur Arch Psychiatry Clin Nuerosci 2005, 255:167-173.
  • [37]Weiser M, van Os J, Davidson M: Time for a shift in focus in schizophrenia: from narrow phenotypes to broad endophenotypes. Br J Psychiatry 2005, 187:203-205.
  • [38]Kotov R, Chang S-W, Fochtmann LJ, Mojtabai R, Carlson GA, Sedler MJ, Bromet EJ: Schizophrenia in the internalizing-externalizing framework: A third dimension? Schizophr Bull 2011, 37:1168-1178.
  • [39]van Nierop M, van Os J, Gunther N, Myin-Germeys I, de Graaf R, ten Have M, van Dorsselaer S, Bak M, van Winkel R: Phenotypically continuous with clinical psychosis, discontinuous in need for care: evidence for an extended psychosis phenotype. Schizophr Bull 2012, 38:231-238.
  • [40]Wigman JTW, van Nierop M, Vollebergh WAM, Lieb R, Beesdo-Baum K, Wittchen H-U, van Os J: Evidence that psychotic symptoms are prevalent in disorders of anxiety and depression, impacting on illness onset, risk, and severity - implications for diagnosis and ultra–high risk research. Schizophr Bull 2012, 38:247-257.
  • [41]Carr V, Halpin S, Lau N, O'Brien S, Beckmann J, Lewin T: A risk factor screening and assessment protocol for schizophrenia and related psychosis. Aust N Z J Psychiatry 2000, 34:S170-S180.
  • [42]Phillips LJ, Yung AR, McGorry PD: Identification of young people at risk of psychosis: validation of Personal Assessment and Crisis Evaluation Clinic intake criteria. Aust N Z J Psychiatry 2000, 34(Suppl):S164-169.
  • [43]Power P, McGuire P, Iacoponi E, Garety P, Morris E, Valmaggia L, Grafton D, Craig T: Lambeth Early Onset (LEO) and Outreach & Support in South London (OASIS) service. Early Interv Psychiatry 2007, 1:97-103.
  • [44]Yung AR, McGorry PD, Francey SM, Nelson B, Baker K, Phillips LJ, Berger G, Amminger GP: PACE: a specialised service for young people at risk of psychotic disorders. Med J Aust 2007, 187:S43-46.
  • [45]Schultze-Lutter F, Ruhrmann S, Klosterkotter J: Early detection of psychosis - establishing a service for persons at risk. Eur Psychiatry 2009, 24:1-10.
  • [46]Meneghelli A, Cocchi A, Preti A: 'Programma2000': a multi-modal pilot programme on early intervention in psychosis underway in Italy since 1999. Early Interv Psychiatry 2010, 4:97-103.
  • [47]Uzenoff SR, Penn DL, Graham KA, Saade S, Smith BB, Perkins DO: Evaluation of a multi-element treatment center for early psychosis in the United States. Soc Psychiatry Psychiatr Epidemiol 2012, 47:1607-1615.
  • [48]Fusar-Poli P, Bonoldi I, Yung AR, Borgwardt S, Kempton MJ, Valmaggia L, Barale F, Caverzasi E, McGuire P: Predicting psychosis: Meta-analysis of transition outcomes in individuals at high clinical risk. Arch Gen Psychiatry 2012, 69:220-229.
  • [49]Phillips LJ, Velakoulis D, Pantelis C, Wood S, Yuen HP, Yung AR, Desmond P, Brewer W, McGorry PD: Non-reduction in hippocampal volume is associated with higher risk of psychosis. Schizophr Res 2002, 58:145-158.
  • [50]Cocchi A, Meneghelli A, Erlicher A, Pisano A, Cascio M, Preti A: Patterns of referral in first-episode schizophrenia and ultra high-risk individuals: results from an early intervention program in Italy. Soc Psychiatry Psychiatr Epidemiol 2013, 48:1905-1916.
  • [51]Yung AR, Pan Yuen H, Mcgorry PD, Phillips LJ, Kelly D, Dell'olio M, Francey SM, Cosgrave EM, Killackey E, Stanford C, Godfrey K, Buckby J: Mapping the onset of psychosis: the Comprehensive Assessment of at-Risk Mental States. Aust N Z J Psychiatry 2005, 39:964-971.
  • [52]A Contributing Life: The 2013 National Report Card on Mental Health and Suicide Prevention. NMHC, Sydney; 2013.
  • [53]Yung AR, Stanford C, Cosgrave E, Killackey E, Phillips LJ, Nelson B, McGorry PD: Testing the Ultra High Risk (prodromal) criteria for the prediction of psychosis in a clinical sample of young people. Schizophr Res 2006, 84:57-66.
  • [54]Rickwood DJ, Telford NR, Parker AG, Tanti CJ, McGorry PD: Headspace - Australia's innovation in youth mental health: who are the clients and why are they presenting? Med J Aust 2014, 200:108-111.
  文献评价指标  
  下载次数:11次 浏览次数:12次