Herpes simplex virus infections among rural residents in eastern China

BMC Infectious Diseases

Meiyang Gao¹  Li Chen¹  Jifu Feng³  Meifang Su²  Na He¹  Haijiang Lin³ 

[1] Department of Epidemiology, School of Public Health, Fudan University; Key Laboratory of Public Health Safety (Fudan University), Ministry of Education, PR China;Yuhuan County Center for Disease Control and Prevention, Zhejiang Province, PR China;Taizhou City Center for Disease Control and Prevention, Zhejiang Province, PR China

关键词: Eastern China;    Community residents;    Hepatitis B virus;    Herpes simplex virus;    Seroprevalence;   

Others  :  1175780
DOI  :  10.1186/1471-2334-11-69

 received in 2010-05-19, accepted in 2011-03-18,  发布年份 2011

【 摘 要 】

Background

Herpes simplex virus (HSV) has two types: HSV-1 and HSV-2. Both infect epithelial cells and establish latent infections in neurons causing an infection that persists for life. Information on age- and gender-specific seroprevalence of HSV-1 and HSV-2 is valuable for understanding HSV transmission dynamics and designing population-based prevention and intervention programs for HSV. However, such information is not available for China.

Methods

Cryopreserved serum samples of all subjects aged 5 to 60 years from two randomly selected rural villages in Zhejiang province in Eastern China who had participated in the China national seroepidemiological survey of hepatitis B virus (HBV) infection conducted in 2006 were tested. Seroprevalence of HSV-1 and HSV-2 infections were determined by type-specific IgG antibody tests using an ELISA technique. Their 95% confidence intervals adjusted for the sampling fraction were calculated according to the Clopper-Pearson method.

Results

A total of 2,141 residents participated in the survey, with a response rate of 82.3%. HSV-1 seroprevalence was 92.0% overall, 89.1% for males and 94.2% for females. HSV-1 seroprevalence was 61.6% among children aged 5-9 years, 90.3% among 25-29 years, and nearly 100% among those aged > = 40 years. HSV-2 seroprevalence was 13.2% overall, 10.5% for males and 15.3% for females. No children aged 5-14 years were HSV-2 positive, and HSV-2 seroprevalence was 7.1% among 15-19 years and peaked at 24.3% among those aged 45-49 years. Neither HSV-1 nor HSV-2 infections were significantly different by gender. About 11.8% of study subjects were co-infected with both types of HSV. Among 549 participating couples, 8.6% were HSV-1 serodiscordant and 11.8% were HSV-2 serodiscordant. No one tested positive for HIV. The overall prevalence of HBsAg was 16.2%, 16.9% for males and 15.4% for females.

Conclusions

HSV-1 was highly prevalent among all rural residents aged between 5-60 years in Eastern China, whereas HSV-2 was prevalent among sexually active people. HSV-1 and HSV-2 have different transmission modes and dynamics. Future HSV prevention and control programs in China should be type specific.

【 授权许可】

   
2011 Lin et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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