Intraventricular hemorrhage in asphyxiated newborns treated with hypothermia: a look into incidence, timing and risk factors

BMC Pediatrics

Pia Wintermark¹  Michael Shevell⁴  Christine Saint-Martin²  Xianming Tan³  Elodie Boudes¹  Ghalia Al Yazidi⁴ 

[1] Division of Newborn Medicine, Department of Pediatrics, Montreal Children’s Hospital, McGill University, 1001 Boul. Decarie, Site Glen, Block E, EM0.3244, Montreal H4A 3J1, QC, Canada;Department of Radiology, Montreal Children’s Hospital, McGill University, Montreal, Canada;Biostatistics Core Facility, Research Institute, McGill University Health Centre, Montreal, Canada;Division of Pediatric Neurology, Department of Pediatrics, Montreal Children’s Hospital, McGill University, Montreal, Canada

关键词: Newborn brain;    Magnetic resonance imaging;    Intraventricular hemorrhage;    Neonatal encephalopathy;    Hypothermia;    Birth asphyxia;   

Others  :  1224645
DOI  :  10.1186/s12887-015-0415-7

 received in 2014-12-29, accepted in 2015-08-13,  发布年份 2015

【 摘 要 】

Background

Intraventricular hemorrhage (IVH) is uncommon in term newborns. Asphyxia and hypothermia have been mentioned separately as possible risk factors of IVH, since they might cause fluctuations of cerebral blood flow. The aim of this study was to assess the incidence, the timing, and the risk factors of intraventricular hemorrhage (IVH) in term asphyxiated newborns treated with hypothermia.

Methods

We conducted a prospective cohort study of all term asphyxiated newborns treated with hypothermia from August 2008 to June 2013. The presence or not of IVH was assessed using brain magnetic resonance imaging (MRI) performed after the hypothermia treatment was completed or using head ultrasound during the hypothermia treatment. For these newborns, to determine the timing of IVH, we retrospectively reviewed if they had other brain imaging studies performed during their neonatal hospitalization stay. In addition, we compared their general characteristics with those not developing IVH.

Results

One hundred and sixty asphyxiated newborns met the criteria for hypothermia. Fifteen of these newborns developed IVH, leading to an estimate of 9 % (95 % CI: 5.3-15.0 %) of IVH in this population of newborns. Fifty-three percent had hemorrhage limited to the choroid plexus or IVH without ventricular dilatation; 47 % had IVH with ventricular dilatation or parenchymal hemorrhage. Sixty-seven percent had an initial normal brain imaging; the diagnostic brain imaging that demonstrated the IVH was obtained either during cooling (in 30 %), within 24 h of the rewarming (in 30 %), or 24 h after the rewarming (in 40 %). Recurrent seizures were the presenting symptom of IVH during the rewarming in 20 % of the newborns. Coagulopathy was more frequent in the asphyxiated newborns developing IVH (p < 0.001). The asphyxiated newborns developing IVH also presented more frequently with persistent pulmonary hypertension, hypotension, thrombocytopenia and coagulopathy (p = 0.03).

Conclusions

The asphyxiated newborns treated with hypothermia appear to be at an increased risk of IVH, especially those with significant hemodynamic instability. IVH seems to develop during late hypothermia and rewarming. Efforts should be directed towards maintaining hemodynamic stability in these patients, even during the rewarming.

【 授权许可】

   
2015 Al Yazidi et al.

【 图 表 】

Fig. 1.

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