FGF21 protects against ox-LDL induced apoptosis through suppressing CHOP expression in THP1 macrophage derived foam cells

BMC Cardiovascular Disorders

Jin-ying Zhang⁵  Shao-hui Niu³  Li Li³  Li-qiang Sun³  Tao Wang⁴  Feng Wang²  Ting Wang¹  En Li³ 

[1] Department of Gerontology, Shaanxi People’s Hospital, Xi’an, P. R. China;CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P. R. China;Department of Cardiovascular internal medicine, The second Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China;Department of Gerontology, The second Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China;Department of Cardiovascular internal medicine, The first Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China

关键词: CHOP;    Foam cell;    FGF21;    ER stress;    Macrophage;   

Others  :  1221379
DOI  :  10.1186/s12872-015-0077-2

 received in 2014-10-10, accepted in 2015-07-24,  发布年份 2015

【 摘 要 】

Background

FGF21,as a member of the fibroblast growth factor superfamily, is an important endogenous regulator to systemic glucose and lipid metabolism. Elevated serum FGF21 levels have been reported in subjects with coronary heart disease and carotid artery plaques. The formation and apoptosis of foam cell, induced by ox-LDL and oxysterols, are key steps in the development of atherosclerosis.

Methods

In this study, THP1 derived macrophages were induced into foam cells by ox-LDL or sterols. The formation and apoptosis of foam cells treated with or without FGF21 were analyzed.

Results

We demonstrated that the accumulation of cholesterol was decreased after FGF21 treatment in THP1 macrophage derived foam cells. Consistently, the apoptosis of macrophage was alleviated dramatically with FGF21 treatment. ERK1/2 knockdown didn’t abrogate the effect of FGF21 on THP1 macrophage derived foam cells. However, FGF21 suppressed the induced expression of CHOP and DR5 in THP1 macrophage derived foam cells.

Conclusion

FGF21 protects against the formation and apoptosis of THP1 macrophages derived foam cells through suppressing the expression of CHOP.

【 授权许可】

   
2015 Li et al.

【 图 表 】

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