High mortality of pneumonia in cirrhotic patients with ascites

BMC Gastroenterology

Chen-Chi Tsai²  Chih-Chun Tsai¹  Kuo-Chih Tseng³  Yu-Hsi Hsieh³  Chih-Wei Tseng³  Tsung-Hsing Hung³ 

[1]Department of Mathematics, Tamkang University, Tamsui, Taiwan

[2]Division of Infectious disease, Department of Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan

[3]School of Medicine, Tzu Chi University, Hualien, Taiwan

关键词: Spontaneous bacterial peritonitis;    Pneumonia;    Infections;    Ascites;    Cirrhosis;   

Others  :  858192
DOI  :  10.1186/1471-230X-13-25

 received in 2012-07-01, accepted in 2013-01-28,  发布年份 2013

【 摘 要 】

Background

Cirrhotic patients with ascites are prone to develop various infectious diseases. This study aimed to evaluate the occurrence and effect of major infectious diseases on the mortality of cirrhotic patients with ascites.

Methods

We reviewed de-identified patient data from the National Health Insurance Database, derived from the Taiwan National Health Insurance Program, to enroll 4,576 cirrhotic patients with ascites, who were discharged from Taiwan hospitals between January 1, 2004 and June 30, 2004. We collected patients’ demographic and clinical data, and reviewed diagnostic codes to determine infectious diseases and comorbid disorders of their hospitalizations. Patients were divided into an infection group and non-infection group and hazard ratios (HR) were determined for specific infectious diseases.

Results

Of the total 4,576 cirrhotic patients with ascites, 1,294 (28.2%) were diagnosed with infectious diseases during hospitalization. The major infectious diseases were spontaneous bacterial peritonitis (SBP) (645, 49.8%), urinary tract infection (151, 11.7%), and pneumonia (100, 7.7%). After adjusting for patients’ age, gender, and other comorbid disorders, the HRs of infectious diseases for 30-day and 90-day mortality of cirrhotic patients with ascites were 1.81 (1.54-2.11) and 1.60 (1.43-1.80) respectively, compared to those in the non-infection group. The adjusted HRs of pneumonia, urinary tract infection (UTI), spontaneous bacterial peritonitis (SBP), and sepsis without specific focus (SWSF) were 2.95 (2.05-4.25), 1.32 (0.86-2.05), 1.77 (1.45-2.17), and 2.19 (1.62-2.96) for 30-day mortality, and 2.57 (1.93-3.42), 1.36 (1.01-1.82), 1.51 (1.29-1.75), and 2.13 (1.70-2.66) for 90-day mortality, compared to those in the non-infection group.

Conclusion

Infectious diseases increased 30-day and 90-day mortality of cirrhotic patients with ascites. Among all infectious diseases identified, pneumonia carried the highest risk for mortality.

【 授权许可】

   
2013 Hung et al; licensee BioMed Central Ltd.

【 图 表 】

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