Combined effect of mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on estimated glomerular filtration rate in male Japanese health check-up examinees: a cross-sectional study

BMC Nephrology

Yutaka Takashima³  Hiromi Hoshino¹  Hirotaka Ochiai¹  Takako Shirasawa¹  Tadahiro Ohtsu¹  Naoki Shimada¹  Masao Yoshida³  Kanae Karita³  Naomi Matsunaga³  Mamoru Ishikawa²  Akatsuki Kokaze³ 

[1] Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan;Mito Red Cross Hospital, 3-12-48 Sannomaru, Mito-shi, Ibaraki, 310-0011, Japan;Department of Public Health, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo, 181-8611, Japan

关键词: Mitochondrial DNA polymorphism;    Estimated glomerular filtration rate;    Chronic kidney disease;    Alcohol;   

Others  :  1083003
DOI  :  10.1186/1471-2369-14-35

 received in 2012-01-16, accepted in 2013-02-04,  发布年份 2013

【 摘 要 】

Background

Prevention of chronic kidney disease (CKD) is a major public health issue. Although several studies have been performed on the association between alcohol consumption and CKD or renal function, it remains controversial. Numerous genetic polymorphisms have been reported to be associated with CKD and kidney function. Mitochondrial DNA cytosine/adenine (Mt5178 C/A) polymorphism is associated with longevity in Japanese. This polymorphism modifies the effects of alcohol consumption on blood pressure, risk of hypertension, serum triglyceride levels, risk of hyper-LDL cholesterolemia and serum uric acid levels. The objective of this study was to investigate whether Mt5178 C/A polymorphism modifies the effects of alcohol consumption on renal function in male Japanese health check-up examinees.

Methods

A total of 394 male subjects aged 29–76 years were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the combined effects of Mt5178 C/A polymorphism and habitual drinking on the risk of mildly decreased estimated glomerular filtration rate (eGFR) (<90 ml/min/1.73 m²) was conducted.

Results

For Mt5178A genotypic men, habitual drinking may increase eGFR (P for trend = 0.003) or reduce the risk of mildly decreased eGFR (P for trend = 0.003). Daily drinkers had a significantly higher eGFR than non-drinkers (P = 0.005). The crude odds ratio for decreased eGFR was significantly lower in daily drinkers than in non-drinkers (odds ratio = 0.092, 95% confidence interval: 0.012-0.727, P = 0.024). On the other hand, for Mt5178C genotypic men, habitual drinking does not appear to affect eGFR.

Conclusion

The present results suggest a joint effect of Mt5178 C/A polymorphism and alcohol consumption on eGFR and the risk of mildly decreased eGFR in male Japanese subjects.

【 授权许可】

   
2013 Kokaze et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Coresh J, Selvin E, Stevens LA, Manzi J, Kusek JW, Eggers P, Van Lente F, Levey AS: Prevalence of chronic kidney disease in the United States. JAMA 2007, 298:2038-2047.
• [2]Imai E, Horio M, Watanabe T, Iseki K, Yamagata K, Hara S, Ura S, Kiyohara Y, Moriyama T, Ando Y, Fujimoto S, Konta T, Yokoyama H, Makino H, Hishida A, Matsuo S: Prevalence of chronic kidney disease in the Japanese general population. Clin Exp Nephrol 2009, 13:621-630.
• [3]National Kidney Foundation: K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 2002, 39(Suppl 1):S1-S266.
• [4]Vupputuri S, Sandler DP: Lifestyle risk factors and chronic kidney disease. Ann Epidemiol 2003, 13:712-720.
• [5]Perneger TV, Whelton PK, Puddey IB, Klag MJ: Risk of end-stage renal disease associated with alcohol consumption. Am J Epidemiol 1999, 150:1275-1281.
• [6]Shankar A, Klein R, Klein BE: The association among smoking, heavy drinking, and chronic kidney disease. Am J Epidemiol 2006, 164:263-271.
• [7]Schaeffner ES, Kurth T, de Jong PE, Glynn RJ, Buring JE, Gaziano JM: Alcohol consumption and the risk of renal dysfunction in apparently healthy men. Arch Intern Med 2005, 165:1048-1053.
• [8]Funakoshi Y, Omori H, Onoue A, Mihara S, Ogata Y, Katoh T: Association between frequency of drinking alcohol and chronic kidney disease in men. Environ Health Prev Med 2012, 17:199-204.
• [9]Tanaka M, Gong JS, Zhang J, Yoneda M, Yagi K: Mitochondrial genotype associated with longevity. Lancet 1998, 351:185-186.
• [10]Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Satoh M, Teruya K, Masuda Y, Honmyo R, Uchida Y, Takashima Y: NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies the effects of alcohol consumption on risk for hypertension in middle-aged Japanese men. Hypertens Res 2007, 30:213-218.
• [11]Wang D, Taniyama M, Suzuki Y, Katagiri T, Ban Y: Association of the mitochondrial DNA 5178 A/C polymorphism with maternal inheritance and onset of type 2 diabetes in Japanese patients. Exp Clin Endocrinol Diabetes 2001, 109:361-364.
• [12]Mukae S, Aoki S, Itoh S, Satoh R, Nishio K, Iwata T, Katagiri T: Mitochondrial 5178A/C genotype is associated with acute myocardial infarction. Circ J 2003, 67:16-20.
• [13]Takagi K, Yamada Y, Gong JS, Sone T, Yokota M, Tanaka M: Association of a 5178C→A (Leu237Met) polymorphism in the mitochondrial DNA with a low prevalence of myocardial infarction in Japanese individuals. Atherosclerosis 2004, 175:281-286.
• [14]Ohkubo R, Nakagawa M, Ikeda K, Kodama T, Arimura K, Akiba S, Saito M, Ookatsu Y, Atsuchi Y, Yamano Y, Osame M: Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders. J Neurol Sci 2002, 198:31-35.
• [15]Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Sekine Y, Sekiguchi K, Harada M, Satoh M, Teruya K, Takeda N, Fukazawa S, Uchida Y, Takashima Y: Longevity-associated mitochondrial DNA 5178 A/C polymorphism and blood pressure in the Japanese population. J Hum Hypertens 2004, 18:41-45.
• [16]Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Sekine Y, Sekiguchi K, Satoh M, Harada M, Teruya K, Takeda N, Uchida Y, Tsunoda T, Takashima Y: Longevity-associated mitochondrial DNA 5178 A/C polymorphism modulates effects of daily drinking and cigarette consumption on serum triglyceride levels in middle-aged Japanese men. Exp Gerontol 2003, 38:1071-1076.
• [17]Kawamoto T, Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Shimada N, Ohtsu T, Shirasawa T, Ochiai H, Ito T, Hoshino H, Takashima Y: Joint effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on risk of hyper-LDL cholesterolemia in middle-aged Japanese men. Lipids Health Dis 2011, 10:105. BioMed Central Full Text
• [18]Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Satoh M, Teruya K, Honmyo R, Yorimitsu M, Matsuda Y, Uchida Y, Takashima Y: Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism influences the effects of alcohol consumption on serum uric acid levels in nonobese Japanese men. J Hum Genet 2006, 51:765-771.
• [19]Okada R, Suzuki K, Ito Y, Nishio K, Ishida Y, Kawai S, Goto Y, Naito M, Wakai K, Hamajima N: Association between decreased kidney function and endotoxin receptor CD14 C-159T polymorphism among Japanese health check-up examination. Ren Fail 2007, 29:967-972.
• [20]Konta T, Takasaki S, Ichikawa K, Emi M, Toriyama S, Satoh H, Ikeda A, Suzuki K, Mashima Y, Shibata Y, Watanabe T, Kato T, Kawata S, Kubota I: The novel and independent association between single-point SNP of NPHP4 gene and renal function in non-diabetic Japanese population: the Takahata study. J Hum Genet 2010, 55:791-795.
• [21]Yoshida T, Kato K, Fujimaki T, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Tanaka M, Nozawa Y, Kimura G, Yamada Y: Association of genetic variants with chronic kidney disease in Japanese individuals. Clin J Am Soc Nephrol 2009, 4:883-890.
• [22]Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y: Association of gene polymorphisms with chronic kidney disease in Japanese individuals. Int J Mol Med 2009, 24:539-547.
• [23]Yoshida T, Kato K, Horibe H, Oguri M, Fukuda M, Satoh K, Aoyagi Y, Shinkai S, Nozawa Y, Yamada Y: Association of a genetic variant of BTN2A1 with chronic kidney disease in Japanese individuals. Nephrology 2011, 16:642-648.
• [24]Hirose T, Totsune K, Nakashige Y, Metoki H, Kikuya M, Ohkubo T, Hara A, Satoh M, Inoue R, Asayama K, Kondo T, Kamide K, Katsuya T, Ogihara T, Izumi S, Rakugi H, Takahashi K, Imai Y: Influence of adrenomedullin 2/intermedin gene polymorphism on blood pressure, renal function and silent cerebrovascular lesions in Japanese: the Ohasama study. Hypertens Res 2011, 34:1327-1332.
• [25]Okada R, Wakai K, Naito M, Morita E, Kawai S, Hamajima N, Hara M, Takashima N, Suzuki S, Takezaki T, Ohnaka K, Arisawa K, Hirohata H, Matsuko K, Mikami H, Kubo M, Tanaka H, Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group: Pro-/anti-inflammatory cytokine gene polymorphisms and chronic kidney disease: a cross-sectional study. BMC Nephrol 2012, 13:2. BioMed Central Full Text
• [26]Levine DZ: Hyperfiltration, nitric oxide, and diabetic nephropathy. Curr Hypertens Rep 2006, 8:153-157.
• [27]Matsuo S, Imai E, Horio M, Yasuda Y, Tomota K, Nitta K, Yamagata K, Tomino Y, Yokoyama H, Hishida A, Collaborators developing the Japanese equation for estimated GFR: Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis 2009, 53:982-992.
• [28]Madamanchi NR, Runge MS: Mitochondrial dysfunction in atherosclerosis. Circ Res 2007, 100:460-473.
• [29]Gusdon AM, Votyakova TV, Mathews CE: mt-Nd2a suppresses reactive oxygen species production by mitochondrial complexes I and III. J Biol Chem 2008, 283:10690-10697.
• [30]Stadtman ER, Moskovitz J, Levine RL: Oxidation of methionine residues of proteins: biological consequences. Antioxid Redox Signal 2003, 5:577-582.
• [31]Das SK, Vasudevan DM: Alcohol-induced oxidative stress. Life Sci 2007, 81:177-187.
• [32]Yuan Q, Hong S, Han S, Zeng L, Liu F, Ding G, Kang Y, Mao J, Cai M, Zhu Y, Wang QX: Preconditioning with physiological levels of ethanol protect kidney against ischemia/reperfusion injury by modulating oxidative stress. PLoS One 2011, 6:e25811.