The presence of cariogenic and periodontal pathogens in the oral cavity of one-year-old infants delivered pre-term with very low birthweights: a case control study

BMC Oral Health

Jiri Dort³  Zdenek Broukal²  Romana Koberova-Ivancakova⁴  Vlasta Merglova¹ 

[1] Department of Dentistry, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 80, 304 60 Pilsen, Czech Republic;Institute of Clinical and Experimental Dental Medicine of Charles University in Prague, Karlovo nam 554/32, 120 00 Prague, Czech Republic;Department of Neonatology, Faculty Hospital in Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic;Department of Dentistry, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Sokolská 581, 500 05 Hradec Kralove, Czech Republic

关键词: S. mutans;    Pre-term infants;    Periodontal pathogens;    Dental caries;    Cariogenic microbes;   

Others  :  1091992
DOI  :  10.1186/1472-6831-14-109

 received in 2014-05-03, accepted in 2014-08-26,  发布年份 2014

【 摘 要 】

Background

Recently, the dental literature has focused mainly on the microbial colonization of healthy full-term infants and their mothers or caretakers. However, oral microbial acquisition by premature infants has not been adequately investigated, and the correlation between pre-term birth and the presence of cariogenic and periodontal pathogens has not been determined. The aim of this study was to identify the presence and quantities of representative cariogenic and periodontal pathogens in the oral cavities of 12-month-old infants and compare the occurrence of these microbes between a cohort of pre-term infants with very low birthweights and a control cohort comprising full-term infants.

Methods

The research cohort was composed of 69 one-year-old infants, of whom 24 were born prematurely with very low birthweights and 45 of whom were carried to full term. Information regarding the infants’ gestational age, mode of delivery, general health status, birthweight and antibiotic use were obtained from hospital records and through oral interviews. At 12 months of age, both groups of infants were examined, and unstimulated saliva samples from the dorsum of the tongue and dental plaque samples were collected. The microorganisms (Streptococcus mutans, Lactobacillus spp., Actinomyces spp., Aggregatibacter actinomycetemcomitans,Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Peptostreptococcusmicros, Prevotella intermedia, Fusobacterium nucleatum) were identified and their quantities were evaluated using a PCR-based method. The chi-squared and Fisher’s factorial tests were used for the statistical evaluations.

Results

The infants had a high prevalence of cariogenic microbes and of Fusosbacterium nucleatum and Aggregatibacter actinomycetemcomitans. Cariogenic microbes were detected in 91.7% of the very low birthweight infants and in all full-term infants. Periodontal pathogens were present in 83% of the pre-term infants and in 96% of the full-term infants. A significant difference was found between the cohorts in terms of the presence of S. mutans. Most of the very low birthweight infants had negative values of this microbe, while the full-term infants had positive values.

Conclusions

This study confirms the early transmission of representative cariogenic and periodontal pathogens to the oral cavity of one-year-old infants and a higher prevalence of S. mutans in full-term infants than in premature infants.

【 授权许可】

   
2014 Merglova et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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