Value of SPECT-CT Imaging for Middle-Aged Patients with Chronic Anterior Knee Pain

BMC Musculoskeletal Disorders

Seung-Baik Kang¹  Chong Bum Chang¹  Ho-Young Lee³  Du Hyun Ro² 

[1] Department of Orthopaedic Surgery, SMG-SNU Boramae Medical Center, Seoul, South Korea;Department of Orthopaedic Surgery, Seoul National University College of Medicine, Seoul, South Korea;Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea

关键词: Cartilage, bone;    Chondral lesion;    Patellofemoral arthritis;    SPECT-CT;    Anterior knee pain;   

Others  :  1227717
DOI  :  10.1186/s12891-015-0628-9

 received in 2014-12-08, accepted in 2015-07-13,  发布年份 2015

【 摘 要 】

Background

Single-photon emission computed tomography-computed tomography (SPECT-CT) is a highly sensitive tool for detecting bone metabolism. We determined whether subchondral bone metabolism, as indicated by SPECT-CT in the patellofemoral (PF) joint, predicts response to conservative management in middle-aged patients with chronic anterior knee pain (AKP), and whether SPECT-CT results correlate with arthroscopic assessments of chondral lesions in the PF joint.

Methods

The study group comprised 74 middle-aged patients with chronic AKP. All of the patients underwent SPECT-CT, and the results were graded along a scale of 0 to 3°. After 8 weeks of conservative management, they were grouped as responders (n = 40) or non-responders (n = 34) according to symptom improvement. We compared the median scintigraphic uptake of the PF joint between the two groups, and evaluated the positive predictive value (PPV) of uptake for treatment response in each patient. In non-responders, cartilage condition was assessed during arthroscopy, and the correlation of scintigraphic uptake with severity of the chondral lesion was assessed.

Results

The median scintigraphic uptake in the patella was higher in non-responders than in responders (2 vs. 1). Among patients with higher patella uptake (grade 2 or 3), the PPV for non-response to conservative therapy was 62–67 %, whereas it was 24–25 % in patients with lower uptake (grade 0 or 1). Patella uptake corresponded strongly with arthroscopic assessment of patellar chondral lesions; the correlation was less strong for the femoral trochlea.

Conclusions

Increased subchondral bone metabolism in the patella is associated with responsiveness to conservative therapy. SPECT-CT can benefit clinicians by predicting the treatment response from conservative management.

【 授权许可】

   
2015 Ro et al.

【 图 表 】

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