A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior

BMC Medicine

Michael Maes²  Michael Berk¹  Piotr Galecki⁵  George Anderson³  Gerwyn Morris⁴ 

[1]Department of Psychiatry, University of Melbourne, Level 1 North, Main Block, Royal Melbourne Hospital, Parkville, 3052, Australia

[2]Department of Psychiatry, Chulalongkorn University, Rama 4 Road 1873, Pathumwan, Bangkok, 10330, Thailand

[3]CRC Clinical Research Centre/Communications, Laurel Street 57, Glasgow, G11 7QT,UK

[4]Tir Na Nog, Bryn Road Seaside 87, Llanelli, SA152LW, UK

[5]Department of Adult Psychiatry, Medical University of Lodz, Aleksandrowska 159, Lodz, 91229, Poland

关键词: sickness behavior;    oxidative stress;    ME;    inflammation;    depression;    chronic fatigue;    CFS;   

Others  :  857155
DOI  :  10.1186/1741-7015-11-64

 received in 2012-10-11, accepted in 2013-03-08,  发布年份 2013

【 摘 要 】

It is of importance whether myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a variant of sickness behavior. The latter is induced by acute infections/injury being principally mediated through proinflammatory cytokines. Sickness is a beneficial behavioral response that serves to enhance recovery, conserves energy and plays a role in the resolution of inflammation. There are behavioral/symptomatic similarities (for example, fatigue, malaise, hyperalgesia) and dissimilarities (gastrointestinal symptoms, anorexia and weight loss) between sickness and ME/CFS. While sickness is an adaptive response induced by proinflammatory cytokines, ME/CFS is a chronic, disabling disorder, where the pathophysiology is related to activation of immunoinflammatory and oxidative pathways and autoimmune responses. While sickness behavior is a state of energy conservation, which plays a role in combating pathogens, ME/CFS is a chronic disease underpinned by a state of energy depletion. While sickness is an acute response to infection/injury, the trigger factors in ME/CFS are less well defined and encompass acute and chronic infections, as well as inflammatory or autoimmune diseases. It is concluded that sickness behavior and ME/CFS are two different conditions.

【 授权许可】

   
2013 Morris et al; licensee BioMed Central Ltd.

【 图 表 】

【 参考文献 】

• [1]Hetem RS, Mitchell D, Maloney SK, Meyer LC, Fick LG, Kerley GI, Fuller A: Fever and sickness behavior during an opportunistic infection in a free-living antelope, the greater kudu (Tragelaphus strepsiceros). Am J Physiol Regul Integr Comp Physiol 2008, 294:R246-R254.
• [2]Hart BL: Biological basis of the behavior of sick animals. Neurosci Biobehav Rev 1988, 12:123-137.
• [3]Maes M, Berk M, Goehler L, Song C, Anderson G, Gałecki P, Leonard B: Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways. BMC Med 2012, 10:66. BioMed Central Full Text
• [4]Kluger MJ: The evolution and adaptive value of fever. Am Sci 1978, 66:38-43.
• [5]Maier SF, Watkins LR: Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol Rev 1998, 105:83-107.
• [6]Wynne AM, Henry CJ, Godbout JP: Immune and behavioral consequences of microglial reactivity in the aged brain. Integr Comp Biol 2009, 49:254-266.
• [7]Charlton BG: The malaise theory of depression: major depressive disorder is sickness behavior and antidepressants are analgesic. Med Hypotheses 2000, 54:126-130.
• [8]Komaroff AL, Fagioli LR, Doolittle TH, Gandek B, Gleit MA, Guerriero RT, Kornish RJ II, Ware NC, Ware JE Jr, Bates DW: Health status in patients with chronic fatigue syndrome and in general population and disease comparison groups. Am J Med 1996, 101:281-290.
• [9]Cairns R, Hotopf M: A systematic review describing the prognosis of chronic fatigue syndrome. Occup Med (Lond) 2005, 55:20-31.
• [10]Carruthers BM, van de Sande MI, De Meirleir KL, Klimas NG, Broderick G, Mitchell T, Staines D, Powles AC, Speight N, Vallings R, Bateman L, Baumgarten-Austrheim B, Bell DS, Carlo-Stella N, Chia J, Darragh A, Jo D, Lewis D, Light AR, Marshall-Gradisbik S, Mena I, Mikovits JA, Miwa K, Murovska M, Pall ML, Stevens S: Myalgic encephalomyelitis: international consensus criteria. J Intern Med 2011, 270:327-338.
• [11]Maes M, Twisk FN, Johnson C: Myalgic encephalomyelitis (ME), chronic fatigue syndrome (CFS), and chronic fatigue (CF) are distinguished accurately: results of supervised learning techniques applied on clinical and inflammatory data. Psychiatry Res 2012, 200:754-760.
• [12]Morris G, Maes M: A neuro-immune model of myalgic encephalomyelitis/chronic fatigue syndrome. Metab Brain Dis, in press.
• [13]Maes M, Twisk FN, Ringel K: Inflammatory and cell-mediated immune biomarkers in myalgic encephalomyelitis/chronic fatigue syndrome and depression: inflammatory markers are higher in myalgic encephalomyelitis/chronic fatigue syndrome than in depression. Psychother Psychosom 2012, 81:286-295.
• [14]Arnett SV, Clark IA: Inflammatory fatigue and sickness behaviour - lessons for the diagnosis and management of chronic fatigue syndrome. J Affect Disord 2012, 141:130-142.
• [15]Clark IA, Budd AC, Alleva LM: Sickness behaviour pushed too far--the basis of the syndrome seen in severe protozoal, bacterial and viral diseases and post-trauma. Malar J 2008, 7:208. BioMed Central Full Text
• [16]Fukuda K, Straus SE, Hickie I, Sharpe M, Dobbins JG, Komaroff AL: The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med 1994, 121:953-959.
• [17]Maes M, Twisk FN: Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways. BMC Med 2010, 8:35. BioMed Central Full Text
• [18]Carruthers BM, Jain AK, De Meirleir KL, Peterson DL, Klimas NG, Lerner AM, Bested AC, Flor-Henry P, Joshi P, Powles ACP, Sherkey JA, van de Sande MI: Myalgic encephalomyelitis/chronic fatigue syndrome: clinical working case definition, diagnostic and treatment protocols. J Chron Fatigue Syndr 2003, 11:7-36.
• [19]Maes M: "Functional" or "psychosomatic" symptoms, e.g. a flu-like malaise, aches and pain and fatigue, are major features of major and in particular of melancholic depression. Neuro Endocrinol Lett 2009, 30:564-573.
• [20]Anderson G, Maes M, Berk M: Biological underpinnings of the commonalities in depression, somatization, and chronic fatigue syndrome. Med Hypotheses 2012, 78:752-756.
• [21]Skapinakis P, Lewis G, Mavreas V: Unexplained fatigue syndromes in a multinational primary care sample: specificity of definition and prevalence and distinctiveness from depression and generalized anxiety. Am J Psychiatry 2003, 160:785-787.
• [22]Maes M: An intriguing and hitherto unexplained co-occurrence: depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways. Prog Neuropsychopharmacol Biol Psychiatry 2011, 35:784-794.
• [23]Roy-Byrne P, Afari N, Ashton S, Fischer M, Goldberg J, Buchwald D: Chronic fatigue and anxiety/depression: a twin study. Br J Psychiatry 2002, 180:29-34.
• [24]Zachrisson O, Regland B, Jahreskog M, Kron M, Gottfries CG: A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale). J Psychosom Res 2002, 52:501-509.
• [25]Hawk C, Jason LA, Torres-Harding S: Differential diagnosis of chronic fatigue syndrome and major depressive disorder. Int J Behav Med 2006, 13:244-251.
• [26]Anand AC, Kumar R, Rao MK, Dham SK: Low grade pyrexia: is it chronic fatigue syndrome? J Assoc Physicians India 1994, 42:, 606-608.
• [27]Camus F, Henzel D, Janowski M, Raguin G, Leport C, Vildé JL: Unexplained fever and chronic fatigue: abnormal circadian temperature pattern. Eur J Med 1992, 1:30-36.
• [28]Freeman R, Komaroff AL: Does the chronic fatigue syndrome involve the autonomic nervous system? Am J Med 1997, 102:357-364.
• [29]Allen J, Murrary A, Di Maria C, Newton JL: Chronic fatigue syndrome and impaired peripheral pulse characteristics on orthostasis - a new potential diagnostic biomarker. Physiol Meas 2010, 33:231-241.
• [30]Newton JL, Okonkwo O, Sutcliffe K, Seth A, Shin J, Jones DEJ: Symptoms of autonomic dysfunction in chronic fatigue syndrome. Q J Med 2007, 100:519-526.
• [31]Winkler AS, Blair D, Marsden JT, Peters TJ, Wessely S, Cleare AJ: Autonomic function and serum erythropoietin levels in chronic fatigue syndrome. J Psychosom Res 2004, 56:179-183.
• [32]Montague TJ, Marrie TJ, Klassen GA, Bewick DJ, Horacek BM: Cardiac function at rest and with exercise in the chronic fatigue syndrome. Chest 1989, 95:779-784.
• [33]Pagani M, Lucini D, Mela GS, Langewitz W, Malliani A: Sympathetic overactivity in subjects complaining of unexplained fatigue. Clin Sci (Lond) 1994, 87:655-661.
• [34]De Becker P, Dendale P, De Meirleir K, Campine I, Vandenborne K, Hagers Y: Autonomic testing in patients with chronic fatigue syndrome. Am J Med 1998, 105:122S-126S.
• [35]Soetekouw PM, Lenders JW, Bleijenberg G, Thien T, van der Meer JW: Autonomic function in patients with chronic fatigue syndrome. Clin Auton Res 1999, 9:334-340.
• [36]Streeten DH, Anderson GH Jr: The role of delayed orthostatic hypotension in the pathogenesis of chronic fatigue. Clin Auton Res 1998, 8:119-124.
• [37]Axelrod Axelrod FB, Chelimsky GG, Weese-Mayer DE: Pediatric autonomic disorders. Pediatrics 2006, 118:309-321.
• [38]Stewart JM: Autonomic nervous system dysfunction in adolescents with postural orthostatic tachycardia syndrome and chronic fatigue syndrome is characterized by attenuated vagal baroreflex and potentiated sympathetic vasomotion. Pediatr Res 2000, 48:218-226.
• [39]Reynolds NL, Brown MM, Jason LA: The relationship of Fennell phases to symptoms among patients with chronic fatigue syndrome. Eval Health Prof 2009, 32:264-280.
• [40]Wilson A, Hickie I, Lloyd A, Hadzi-Pavlovic D, Boughton C, Dwyer J, Wakefield D: Longitudinal study of outcome of chronic fatigue syndrome. Br Med J 1994, 308:756-759.
• [41]Tiersky LA, DeLuca J, Hill N, Dhar SK, Johnson SK, Lange G, Rappolt G, Natelson BH: Longitudinal assessment of neuropsychological functioning, psychiatric status, functional disability and employment status in chronic fatigue syndrome. Appl Neuropsychol 2001, 8:41-50.
• [42]Hill NF, Tiersky LA, Scavalla VR, Lavietes M, Natelson BH: Natural history of severe chronic fatigue syndrome. Arch Phys Med Rehabil 1999, 80:1090-1094.
• [43]Peterson PK, Schenck CH, Sherman R: Chronic fatigue syndrome in Minnesota. Minn Med 1991, 74:21-26.
• [44]Riazi K, Galic MA, Kuzmiski JB, Ho W, Sharkey KA, Pittman QJ: Microglial activation and TNFalpha production mediate altered CNS excitability following peripheral inflammation. Proc Natl Acad Sci USA 2008, 105:17151-17156.
• [45]Kerfoot SM, D'Mello C, Nguyen H, Ajuebor MN, Kubes P, Le T, Swain MG: TNF-alpha-secreting monocytes are recruited into the brain of cholestatic mice. Hepatology 2006, 43:154-162.
• [46]D'Mello C, Le T, Swain MG: Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation. J Neurosci 2009, 29:2089-2102.
• [47]Berk M, Berk L, Dodd S, Jacka FN, Fitzgerald PB, de Castella AR, Filia S, Filia K, Kulkarni J, Jackson HJ, Stafford L: Psychometric properties of a scale to measure investment in the sick role: the Illness Cognitions Scale. J Eval Clin Pract 2012, 18:360-364.
• [48]Peters A: The energy request of inflammation. Endocrinology 2006, 147:4550-4552.
• [49]Bosutti A, Malaponte G, Zanetti M, Castellino P, Heer M, Guarnieri G, Biolo G: Calorie restriction modulates inactivity-induced changes in the inflammatory markers C-reactive protein and pentraxin-3. J Clin Endocrinol Metab 2008, 93:3226-3229.
• [50]MacDonald L, Radler M, Paolini AG, Kent S: Calorie restriction attenuates LPS-induced sickness behavior and shifts hypothalamic signaling pathways to an anti-inflammatory bias. Am J Physiol Regul Integr Comp Physiol 2011, 301:R172-184.
• [51]Straub RH: Evolutionary medicine and chronic inflammatory state-known and new concepts in pathophysiology. J Mol Med (Berl) 2012, 90:523-534.
• [52]Kumar RK, Wakefield D: Inflammation: chronic. eLS 2010. 10.1002/9780470015902.a0000944.pub3
• [53]Vermeulen RC, Kurk RM, Visser FC, Sluiter W, Scholte HR: Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity. J Transl Med 2010, 8:93. BioMed Central Full Text
• [54]Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJ: Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Radical Biol Med 2005, 39:584-589.
• [55]Behan WM, More IA, Behan PO: Mitochondrial abnormalities in the postviral fatigue syndrome. Acta Neuropathol 1991, 83:61-65.
• [56]Lane RJ, Barrett MC, Taylor DJ, Kemp GJ, Lodi R: Heterogeneity in chronic fatigue syndrome: evidence from magnetic resonance spectroscopy of muscle. Neuromuscul Disord 1998, 8:204-209.
• [57]Myhill S, Booth NE, McLaren-Howard J: Chronic fatigue syndrome and mitochondrial dysfunction. Int J Clin Exp Med 2009, 2:1-16.
• [58]Morris G, Maes M: Increased nuclear factor-κB and loss of p53 are key mechanisms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Med Hypotheses 2012, 10:66.
• [59]Paul L, Wood L, Behan WM, Maclaren WM: Demonstration of delayed recovery from fatiguing exercise in chronic fatigue syndrome. Eur J Neurol 1999, 6:63-69.
• [60]Arnold DL, Bore PJ, Radda GK, Styles P, Taylor DJ: Excessive intracellular acidosis of skeletal muscle on exercise in a patient with a post-viral exhaustion/fatigue syndrome. Lancet 1984, 323:1367-1369.
• [61]Wong R, Lopaschuk G, Zhu G, Walker D, Catellier D, Burton D, Teo K, Collins-Nakai R, Montague T: Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy. Chest 1992, 102:1716-1722.
• [62]Shungu DC, Weiduschat N, Murrough JW, Mao X, Pillemer S, Dyke JP, Medow MS, Natelson BH, Stewart JM, Mathew SJ: Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. NMR Biomed 2012, 25:1073-1087.
• [63]Murrough JW, Mao X, Collins KA, Kelly C, Andrade G, Nestadt P, Levine SM, Mathew SJ, Shungu DC: Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder. NMR Biomed 2010, 23:643-650.
• [64]Fink MP: Cytopathic hypoxia. Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis? Crit Care Clin 2001, 17:219-237.
• [65]Gottlieb E, Vander Heiden MG, Thompson CB: Bcl-xL prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol 2000, 20:5680-5689.
• [66]Li C, Liu Q, Li N, Chen W, Wang L, Wang Y, Yu Y, Cao X: EAPF/Phafin-2, a novel endoplasmic reticulum-associated protein, facilitates TNF-alpha-triggered cellular apoptosis through endoplasmic reticulum-mitochondrial apoptotic pathway. J Mol Med (Berl) 2008, 86:471-484.
• [67]He Y, Leung KW, Zhang YH, Duan S, Zhong XF, Jiang RZ, Peng Z, Tombran-Tink J, Ge J: Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants. Invest Ophthalmol Vis Sci 2008, 49:1447-1458.
• [68]Mahad DJ, Ziabreva I, Campbell G, Lax N, White K, Hanson PS, Lassmann H, Turnbull DM: Mitochondrial changes within axons in multiple sclerosis. Brain 2009, 132:1161-1174.
• [69]Chakraborty S, Kaushik DK, Gupta M, Basu A: Inflammasome signaling at the heart of central nervous system pathology. J Neurosci Res 2010, 88:1615-1631.
• [70]Xie YW, Wolin MS: Role of nitric oxide and its interaction with superoxide in the suppression of cardiac muscle mitochondrial respiration. Involvement in response to hypoxia/reoxygenation. Circulation 1996, 94:2580-2586.
• [71]Bossy-Wetzel E, Lipton SA: Nitric oxide signaling regulates mitochondrial number and function. Cell Death Differ 2003, 10:757-760.
• [72]Brown GC, Borutaite V: Nitric oxide inhibition of mitochondrial respiration and its role in cell death. Free Radic Biol Med 2002, 33:1440-1450.
• [73]Brown GC, Borutaite V: Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols. Biochim Biophys Acta 2004, 1658:44-49.
• [74]Riobo NA, Clementi E, Melani M, Boveris A, Cadenas E, Moncada S, Poderoso JJ: Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation. Biochem J 2001, 359:139-145.
• [75]Brown GC, Borutaite V: Nitric oxide and mitochondrial respiration in the heart. Cardiovasc Res 2007, 75:283-290.
• [76]Maes M, Mihaylova I, Bosmans E: Not in the mind of neurasthenic lazybones but in the cell nucleus: patients with chronic fatigue syndrome have increased production of nuclear factor kappa beta. Neuro Endocrinol Lett 2007, 28:456-462.
• [77]Allen DG, Lamb GD, Westerbland H: Skeletal muscle fatigue: cellular mechanisms. Physiol Rev 2008, 88:287-332.
• [78]Booth NE, Myhill S, McLaren-Howard J: Mitochondrial dysfunction and the pathophysiology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Int J Clin Exp Med 2012, 5:208-220.
• [79]Atkin TA, MacAskill AF, Brandon NJ, Kittler JT: Disrupted in schizophrenia-1 regulates intracellular trafficking of mitochondria in neurons. Mol Psychiatry 2011, 16:122-124.
• [80]Viljoen M, Panzar A: Sickness behaviour: causes and effects. SA Fam Pract 2004, 45:15-18.
• [81]Marty V, El Hachmane M, Amedee T: Dual modulation of synaptic transmission in the nucleus tractus solitarius by prostaglandin E2 synthesized downstream of IL-1beta. Eur J Neurosci 2008, 27:3132-3150.
• [82]Bechmann I, Galea I, Perry VH: What is the blood-brain barrier (not)? Trends Immunol 2007, 28:5-11.
• [83]Quan N, Banks WA: Brain-immune communication pathways. Brain Behav Immun 2007, 21:727-735.
• [84]Francis J, Chu Y, Johnson AK, Weiss RM, Felder RB: Acute myocardial infarction induces hypothalamic cytokine synthesis. Am J Physiol Heart Circ Physiol 2004, 286:H2264-2271.
• [85]Qin L, Wu X, Block ML, Liu Y, Breese GR, Hong JS, Knapp DJ, Crews FT: Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 2007, 55:453-462.
• [86]Steinshamn S, Waage A: Lack of endotoxin tolerance with respect to TNF alpha production in the subarachnoid space. APMIS 2000, 108:107-112.
• [87]Banks WA, Kastin AJ, Broadwell RD: Passage of cytokines across the blood-brain barrier. Neuroimmunomodulation 1995, 2:241-248.
• [88]Konsman JP, Luheshi GN, Bluthe RM, Dantzer R: The vagus nerve mediates behavioural depression, but not fever, in response to peripheral immune signals; a functional anatomical analysis. Eur J Neurosci 2000, 12:4434-4446.
• [89]Hwang SY, Jung JS, Kim TH, Lim SJ, Oh ES, Kim JY, Ji KA, Joe EH, Cho KH, Han IO: Ionizing radiation induces astrocyte gliosis through microglia activation. Neurobiol Dis 2006, 21:457-467.
• [90]Kluger MJ, Rothenburg BA: Fever and reduced iron: their interaction as a host defense response to bacterial infection. Science 1979, 203:374-376.
• [91]Eskandari F, Webster JI, Sternberg EM: Neural immune pathways and their connection to inflammatory diseases. Arthritis Res Ther 2003, 5:251-265. BioMed Central Full Text
• [92]Tracey KJ: The inflammatory reflex. Nature 2002, 420:853-859.
• [93]Ackerman KD, Felten SY, Bellinger DL, Felten DL: Noradrenergic sympathetic innervation of the spleen: III Development of innervation in the rat spleen. J Neurosci Res 1987, 18:49-54.
• [94]Maes M, Lin A, Kenis G, Egyed B, Bosmans E: The effects of noradrenaline and alpha-2 adrenoceptor agents on the production of monocytic products. Psychiatry Res 2000, 96:245-253.
• [95]Maes M, Twisk FN, Kubera M, Ringel K: Evidence for inflammation and activation of cell-mediated immunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): increased interleukin-1, tumor necrosis factor-α, PMN-elastase, lysozyme and neopterin. J Affect Disord 2012, 136:933-939.
• [96]Heesen C, Nawrath L, Reich C, Bauer N, Schulz KH, Gold SM: Fatigue in multiple sclerosis: an example of cytokine mediated sickness behaviour? J Neurol Neurosurg Psychiatry 2006, 77:34-39.
• [97]Ishikawa T, Kokura S, Sakamoto N, Okajima M, Matsuyama T, Sakai H, Okumura Y, Adachi S, Yoshida N, Uchiyama K, Handa O, Takagi T, Konishi H, Wakabayashi N, Yagi N, Ando T, Uno K, Naito Y, Yoshikawa T: Relationship between circulating cytokine levels and physical or psychological functioning in patients with advanced cancer. Clin Biochem 2012, 45:207-211.
• [98]Bower JE, Ganz PA, Aziz N, Fahey JL: Fatigue and proinflammatory cytokine activity in breast cancer survivors. Psychosom Med 2002, 64:604-611.
• [99]Robson-Ansley PJ, Smith LL: Causes of extreme fatigue in under performing athelethes - a synthesis of recent hypothesis and reviews. SAJSM 2006, 18:108-114.
• [100]Norheim KB, Harboe E, Goransson LG, Omdal R: Interleukin-1 inhibition and fatigue in primary Sjogren's syndrome--a double blind, randomised clinical trial. PLoS ONE 2012, 7:e30123.
• [101]Myers JS, Pierce J, Pazdernik T: Neurotoxicology of chemotherapy in relation to cytokine release, the blood-brain barrier, and cognitive impairment. Oncol Nurs Forum 2008, 35:916-920.
• [102]Dinarello CA: Biologic basis for interleukin-1 in disease. Blood 1996, 87:2095-2147.
• [103]Gemma C, Fister M, Hudson C, Bickford PC: Improvement of memory for context by inhibition of caspase-1 in aged rats. Eur J Neurosci 2005, 22:1751-1756.
• [104]Terrando N, Rei Fidalgo A, Vizcaychipi M, Cibelli M, Ma D, Monaco C, Feldmann M, Maze M: The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction. Crit Care 2010, 14:R88. BioMed Central Full Text
• [105]Chen J, Buchanan JB, Sparkman NL, Godbout JP, Freund GG, Johnson RW: Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system. Brain Behav Immun 2008, 22:301-311.
• [106]Kent S, Bret-Dibat JL, Kelley KW, Dantzer R: Mechanisms of sickness-induced decreases in food-motivated behavior. Neurosci Biobehav Rev 1996, 20:171-175.
• [107]Koo JW, Russo SJ, Ferguson D, Nestler EJ, Duman RS: Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc Natl Acad Sci USA 2010, 107:2669-2674.
• [108]Avitsur R, Yirmiya R: Cytokines inhibit sexual behavior in female rats: I. Synergistic effects of tumor necrosis factor alpha and interleukin-1. Brain Behav Immun 1999, 13:14-32.
• [109]Garcia-Ruiz C, Colell A, Mari M, Morales A, Fernandez-Checa JC: Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species, role of mitochondrial glutathione. J Biol Chem 1997, 272:11369-11377.
• [110]Morgan D, Oliveira-Emilio HR, Keane D, Hirata AE, Santos da Rocha M, Bordin S, Curi R, Newsholme P, Carpinelli AR: Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line. Diabetologia 2007, 50:359-369.
• [111]Merali Z, Lacosta S, Anisman H: Effects of interleukin-1beta and mild stress on alterations of norepinephrine, dopamine and serotonin neurotransmission: a regional microdialysis study. Brain Res 1997, 761:225-235.
• [112]Korkmaz A, Oter S, Seyrek M, Topal T: Molecular, genetic and epigenetic pathways of peroxynitrite-induced cellular toxicity. Interdiscip Toxicol 2009, 2:219-228.
• [113]Glund S, Deshmukh A, Long YC, Moller T, Koistinen HA, Caidahl K, Zierath JR, Krook A: Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle. Diabetes 2007, 56:1630-1637.
• [114]Patarca R: Pteridines and neuroimmune function and pathology. J Chron Fatigue Syndr 1997, 3:69-86.
• [115]Widner B, Laich A, Sperner-Unterweger B, Ledochowski M, Fuchs D: Neopterin production, tryptophan degradation, and mental depression--what is the link? Brain Behav Immun 2002, 16:590-595.
• [116]Bellmann-Weiler R, Schroecksnadel K, Holzer C, Larcher C, Fuchs D, Weiss G: IFN-gamma mediated pathways in patients with fatigue and chronic active Epstein Barr virus-infection. J Affect Disord 2008, 108:171-176.
• [117]Brenu EW, van Driel ML, Staines DR, Ashton KJ, Hardcastle SL, Keane J, Tajouri L, Peterson D, Ramos SB, Marshall-Gradisnik SM: Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis. J Transl Med 2012, 10:88. BioMed Central Full Text
• [118]Chesnokova V, Melmed S: Minireview: neuro-immuno-endocrine modulation of the hypothalamic-pituitary-adrenal (HPA) axis by gp130 signaling molecules. Endocrinology 2002, 143:1571-1574.
• [119]Brenu EW, van Driel ML, Staines DR, Ashton KJ, Ramos SB, Keane J, Klimas NG, Marshall-Gradisnik SM: Immunological abnormalities as potential biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis. J Transl Med 2011, 9:81. BioMed Central Full Text
• [120]Fletcher MA, Zeng XR, Maher K, Levis S, Hurwitz B, Antoni M, Broderick G, Klimas NG: Biomarkers in chronic fatigue syndrome: evaluation of natural killer cell function and dipeptidyl peptidase IV/CD26. PLoS ONE 2010, 5:e10817.
• [121]Mihaylova I, DeRuyter M, Rummens JL, Bosmans E, Maes M: Decreased expression of CD69 in chronic fatigue syndrome in relation to inflammatory markers: evidence for a severe disorder in the early activation of T lymphocytes and natural killer cells. Neuro Endocrinol Lett 2008, 28:477-483.
• [122]Klimas N, Salvato F, Morgan R, Fletcher MA: Immunologic abnormalities in chronic fatigue syndrome. J Clin Microbiol 1990, 28:1403-1410.
• [123]Vaziri ND: Causal link between oxidative stress, inflammation, and hypertension. Iran J Kidney Dis 2008, 2:1-10.
• [124]Murr C, Fuchs D, Gossler W, Hausen A, Reibnegger G, Werner ER, Werner-Felmayer G, Esterbauer H, Wachter H: Enhancement of hydrogen peroxide-induced luminol-dependent chemiluminescence by neopterin depends on the presence of iron chelator complexes. FEBS Lett 1994, 338:223-226.
• [125]Murayama R, Kobayashi M, Takeshita A, Yasui T, Yamamoto M: MAPKs, activator protein-1 and nuclear factor-κB mediate production of interleukin-1β-stimulated cytokines, prostaglandin E2 and MMP-1 in human periodontal ligament cells. J Periodontal Res 2011, 46:568-575.
• [126]Maes M, Mihaylova I, Leunis JC: Chronic fatigue syndrome is accompanied by an IgM-related immune response directed against neopitopes formed by oxidative or nitrosative damage to lipids and proteins. Neuro Endocrinol Lett 2006, 27:615-621.
• [127]Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E: Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder. Neuro Endocrinol Lett 2009, 30:470-476.
• [128]Miwa K, Fujita M: Fluctuation of serum vitamin E (alpha-tocopherol) concentrations during exacerbation and remission phases in patients with chronic fatigue syndrome. Heart Vessels 2010, 25:319-323.
• [129]Jammes Y, Steinberg JG, Delliaux S: Chronic fatigue syndrome: acute infection and history of physical activity affect resting levels and response to exercise of plasma oxidant/antioxidant status and heat shock proteins. J Intern Med 2011, 272:74-84.
• [130]Fulle S, Pietrangelo T, Mancinelli R, Saggini R, Fano G: Specific correlations between muscle oxidative stress and chronic fatigue syndrome: a working hypothesis. J Muscle Res Cell Motil 2007, 28:355-362.
• [131]Maes M, Mihaylova I, Kubera M, Bosmans E: Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome. Neuro Endocrinol Lett 2007, 28:463-469.
• [132]Milczarek R, Hallmann A, Sokołowska E, Kaletha K, Klimek J: Melatonin enhances antioxidant action of alpha-tocopherol and ascorbate against NADPH- and iron-dependent lipid peroxidation in human placental mitochondria. J Pineal Res 2010, 49:149-155.
• [133]Ochoa JJ, Díaz-Castro J, Kajarabille N, García C, Guisado IM, De Teresa C, Guisado R: Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males. J Pineal Res 2011, 51:373-380.
• [134]Maes M, Mihaylova I, Leunis JC: In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation. Neuro Endocrinol Lett 2005, 26:745-751.
• [135]Calder PC: Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale. Biochimie 2009, 91:791-795.
• [136]Esterbauer H, Schaur RJ, Zollner H: Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991, 11:81-128.
• [137]Kumar P, Kale RK, Baquer NZ: Estradiol modulates membrane-linked ATPases, antioxidant enzymes, membrane fluidity, lipid peroxidation, and lipofuscin in aged rat liver. J Aging Res 2011, 2011:580245.
• [138]Garcia JJ, Pinol-Ripoll G, Martinez-Ballarn E, Fuentes-Broto L, Miana-Mena FJ, Venegas C, Caballero B, Escames G, Coto-Montes A, Acuña-Castroviejo D: Melatonin reduces membrane rigidity and oxidative damage in the brain of SAMP(8) mice. Neurobiol Aging 2011, 32:2045-2054.
• [139]Nava F, Carta G: Melatonin reduces anxiety induced by lipopolysaccharide in the rat. Neurosci Lett 2001, 307:57-60.
• [140]Chang CC, Tien CH, Lee EJ, Juan WS, Chen YH, Hung YC, Chen TY, Chen HY, Wu TS: Melatonin inhibits matrix metalloproteinase-9 (MMP-9) activation in the lipopolysaccharide (LPS)-stimulated RAW 264.7 and BV2 cells and a mouse model of meningitis. J Pineal Res 2012, 53:188-197.
• [141]Boullerne A, Petry KG, Geffard M: Circulating antibodies directed against conjugated fatty acids in sera of patients with multiple sclerosis. J Neuroimmunol 1996, 65:75-81.
• [142]Hokama Y, Camproa CE, Hara C, Higa N, Siu N, Lau R, Kuribayashi T, Yabusaki K: Acute phase phospholipids related to the cardiolipin of mitochondria in the sera of patients with chronic fatigue syndrome (CFS), chronic Ciguatera fish poisoning (CCFP), and other diseases attributed to chemicals, Gulf War, and marine toxins. J Clin Lab Anal 2008, 22:99-105.
• [143]Hokama Y, Camproa CE, Hara C, Kuribayashi T, Le Huynh D, Yabusaki K: Anticardiolipin antibodies in the sera of patients with diagnosed chronic fatigue syndrome. J Clin Lab Anal 2009, 23:210-212.
• [144]Buchwald MD, Wener MH, Komaroff AL: Antineuronal antibody levels in chronic fatigue syndrome patients with neurologic abnormalities. 1991, 34:1485-1486.
• [145]Bassi N, Amital D, Amital H, Doria A, Shoenfeld Y: Chronic fatigue syndrome: characteristics and possible causes for its pathogenesis. Isr Med Assoc J 2008, 10:79-82.
• [146]Nishikai M: Antinuclear antibodies in patients with chronic fatigue syndrome. Nippon Rinsho 2007, 65:1067-1070.
• [147]Klein R, Berg PA: High incidence of antibodies to 5-hydroxytryptamine, gangliosides and phospholipids in patients with chronic fatigue and fibromyalgia syndrome and their relatives: evidence for a clinical entity of both disorders. Eur J Med Res 1995, 1:21-26.
• [148]Tanaka S, Kuratsune H, Hidaka Y, Hakariya Y, Tatsumi KI, Takano T, Kanakura Y, Amino N: Autoantibodies against muscarinic cholinergic receptor in chronic fatigue syndrome. Int J Mol Med 2003, 12:225-230.
• [149]Mostafa GA, Ibrahim DH, Shehab AA, Mohammed AK: The role of measurement of serum autoantibodies in prediction of pediatric neuropsychiatric systemic lupus erythematosus. J Neuroimmunol 2010, 227:195-201.
• [150]Kato T, Hatanaka K: Purification of gangliosides by liquid-liquid partition chromatography. J Lipid Res 2008, 49:2474-2478.
• [151]Adelman JS, Bentley GE, Wingfield JC, Martin LB, Hau M: Population differences in fever and sickness behaviors in a wild passerine: a role for cytokines. J Exp Biol 2010, 213:4099-4109.
• [152]Hains LE, Loram LC, Taylor FR, Strand KA, Wieseler JL, Barrientos RM, Young JJ, Frank MG, Sobesky J, Martin TJ, Eisenach JC, Maier SF, Johnson JD, Fleshner M, Watkins LR: Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors. J Neuroimmunol 2011, 239:53-60.
• [153]Besedovsky H, del Rey A, Sorkin E, Dinarello CA: Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 1986, 233:652-654.
• [154]Dunn AJ: Systemic interleukin-1 administration stimulates hypothalamic norepinephrine metabolism parallelling the increased plasma corticosterone. Life Sci 1988, 43:429-435.
• [155]Pavlov VA, Wang H, Czura CJ, Friedman SG, Tracey KJ: The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation. Mol Med 2003, 9:125-134.
• [156]Necela BM, Cidlowski JA: Mechanisms of glucocorticoid receptor action in noninflammatory and inflammatory cells. Proc Am Thorac Soc 2004, 1:239-246.
• [157]Turan T, Izgi HB, Ozsoy S, Tanrıverdi F, Basturk M, Asdemir A, Beşirli A, Esel E, Sofuoglu S: The effects of galantamine hydrobromide treatment on dehydroepiandrosterone sulfate and cortisol levels in patients with chronic fatigue syndrome. Psychiatry Investig 2009, 6:204-210.
• [158]Scott LV, Dinan TG: Urinary free cortisol excretion in chronic fatigue syndrome, major depression and in healthy volunteers. J Affect Disord 1998, 47:49-54.
• [159]Papadopoulos AS, Cleare AJ: Hypothalamic-pituitary-adrenal axis dysfunction in chronic fatigue syndrome. Nat Rev Endocrinol 2011, 8:22-32.
• [160]Tak LM, Cleare AJ, Ormel J, Manoharan A, Kok IC, Wessely S, Rosmalen JG: Meta-analysis and meta-regression of hypothalamic-pituitary-adrenal axis activity in functional somatic disorders. Biol Psychol 2011, 87:183-194.
• [161]Demitrack MA, Dale JK, Straus SE, Laue L, Listwak SJ, Kruesi MJ, Chrousos GP, Gold PW: Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome. J Clin Endocrinol Metab 1991, 73:1224-1234.
• [162]Scott LV, Medbak S, Dinan TG: Blunted adrenocorticotropin and cortisol responses to corticotropin-releasing hormone stimulation in chronic fatigue syndrome. Acta Psychiatr Scand 1998, 97:450-457.
• [163]Scott LV, Teh J, Reznek R, Martin A, Sohaib A, Dinan TG: Small adrenal glands in chronic fatigue syndrome: a preliminary computer tomography study. Psychoneuroendocrinology 1999, 24:759-768.
• [164]Jerjes WK, Taylor NF, Wood PJ, Cleare AJ: Enhanced feedback sensitivity to prednisolone in chronic fatigue syndrome. Psychoneuroendocrinology 2007, 32:192-198.
• [165]Visser J, Lentjes E, Haspels I, Graffelman W, Blauw B, de Kloet R, Nagelkerken L: Increased sensitivity to glucocorticoids in peripheral blood mononuclear cells of chronic fatigue syndrome patients, without evidence for altered density or affinity of glucocorticoid receptors. J Investig Med 2001, 49:195-204.
• [166]Mastorakos G, Chrousos GP, Weber JS: Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans. J Clin Endocrinol Metab 1993, 77:1690-1694.
• [167]Jaattela M, Ilvesmaki V, Voutilainen R, Stenman UH, Saksela E: Tumor necrosis factor as a potent inhibitor of adrenocorticotropin-induced cortisol production and steroidogenic P450 enzyme gene expression in cultured human fetal adrenal cells. Endocrinology 1991, 128:623-639.
• [168]Zhu Q, Solomon S: Isolation and mode of action of rabbit corticostatic (antiadrenocorticotropin) peptides. Endocrinology 1992, 130:1413-1423.
• [169]Harden LM, du Plessis I, Poole S, Laburn HP: Interleukin-6 and leptin mediate lipopolysaccharide-induced fever and sickness behavior. Physiol Behav 2006, 89:146-155.
• [170]Carlton ED, Demas GE, French SS: Leptin, a neuroendocrine mediator of immune responses, inflammation, and sickness behaviors. Horm Behav 2012, 62:272-279.
• [171]Sherry CL, Kramer JM, York JM, Freund GG: Behavioral recovery from acute hypoxia is reliant on leptin. Brain Behav Immun 2009, 23:169-175.
• [172]Lawrence CB, Brough D, Knight EM: Obese mice exhibit an altered behavioural and inflammatory response to lipopolysaccharide. Dis Model Mech 2012, 5:649-659.
• [173]Cleare AJ, O'Keane V, Miell J: Plasma leptin in chronic fatigue syndrome and a placebo-controlled study of the effects of low-dose hydrocortisone on leptin secretion. Clin Endocrinol (Oxf) 2001, 55:113-119.
• [174]Pasco JA, Jacka FN, Williams LJ, Henry MJ, Nicholson GC, Kotowicz MA, Berk M: Leptin in depressed women: cross-sectional and longitudinal data from an epidemiologic study. J Affect Disord 2008, 107:221-225.
• [175]Beccano-Kelly D, Harvey J: Leptin: a novel therapeutic target in Alzheimer's disease? Int J Alzheimers Dis 2012, 2012:594137.
• [176]Farooqui AA, Farooqui T, Panza F, Frisardi V: Metabolic syndrome as a risk factor for neurological disorders. Cell Mol Life Sci 2012, 69:741-762.
• [177]Maloney EM, Boneva RS, Lin JM, Reeves WC: Chronic fatigue syndrome is associated with metabolic syndrome: results from a case-control study in Georgia. Metabolism 2010, 59:1351-1357.
• [178]Roubenoff R, Roubenoff RA, Cannon JG, Kehayias JJ, Zhuang H, Dawson-Hughes B, Dinarello CA, Rosenberg IH: Rheumatoid cachexia: cytokine driven hypermetabolism accompanying reduced body cell mass in chronic inflammation. J Clin Invest 1994, 93:2379-2386.
• [179]Medzhitov R: Inflammation 2010: new adventures of an old flame. Cell 2010, 140:771-776.
• [180]Naess H, Sundal E, Myhr KM, Nyland HI: Postinfectious and chronic fatigue syndromes: clinical experience from a tertiary-referral centre in Norway. In Vivo 2010, 24:185-188.
• [181]Strickland PS, Levine PH, Peterson DL, O'Brien K, Fears T: Neuromyasthenia and chronic fatigue syndrome (CFS) in Northern Nevada/California: a ten-year follow-up of an outbreak. J Chron Fatigue Syndr 2001, 9:3-14.
• [182]Maes M: Inflammatory, and oxidative and nitrosative stress cascades as new drug targets in myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS). In Modern Trends in Pharmacopsychiatry - Inflammation in Psychiatry. Edited by Leonard B, Halaris A. Basel. Switzerland: S. Karger AG; in press.
• [183]Nicolson GL, Nicolson NL, Haier J: Chronic fatigue syndrome patients subsequently diagnosed with Lyme disease Borrelia burgdorferi: evidence for mycoplasma species co-infections. J Chron Fatigue Syndr 2008, 14:5-17.
• [184]Chia JK, Chia AY: Chronic fatigue syndrome is associated with chronic enterovirus infection of the stomach. J Clin Pathol 2008, 61:43-48.
• [185]Hilgers A, Frank J: Chronic fatigue syndrome: immune dysfunction, role of pathogens and toxic agents and neurological and cardial changes. Wien Med Wochenschr 1994, 144:399-406.
• [186]Nicolson GL, Gan R, Haier J: Multiple co-infections (Mycoplasma, Chlamydia, human herpesvirus-6) in blood of chronic fatigue syndrome patients: association with signs and symptoms. APMIS 2003, 111:557-566.
• [187]Goudsmit EM, Howes S: Pacing to manage chronic fatigue syndrome Pacing: an additional strategy to manage fatigue in chronic fatigue syndrome. [http://freespace.virgin.net/david.axford/pacing.htm] webcite
• [188]Kerr JR, Gough J, Richards SC, Main J, Enlander D, McCreary M, Komaroff AL, Chia JK: Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with chronic fatigue syndrome/myalgic encephalomyelitis. J Gen Virol 2010, 91:893-897.
• [189]Broderick G, Fuite J, Kreitz A, Vernon SD, Klimas N, Fletcher MA: A formal analysis of cytokine networks in chronic fatigue syndrome. Brain Behav Immun 2010, 24:1209-1217.
• [190]Zhang L, Gough J, Christmas D, Mattey DL, Richards SC, Main J, Enlander D, Honeybourne D, Ayres JG, Nutt DJ, Kerr JR: Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis. J Clin Pathol 2010, 63:56-164.
• [191]van Langenberg DR, Gibson PR: Systematic review: fatigue in inflammatory bowel disease. Aliment Pharmacol Ther 2010, 32:131-143.
• [192]McKechnie F, Lewis S, Mead G: A pilot observational study of the association between fatigue after stroke and C-reactive protein. J R Coll Physicians Edinb 2010, 40:9-12.
• [193]Pascoe MC, Crewther SG, Carey LM, Crewther DP: Inflammation and depression: why poststroke depression may be the norm and not the exception. Int J Stroke 2011, 6:128-135.
• [194]Fitzpatrick AL, Reed T, Goldberg J, Buchwald D: The association between prolonged fatigue and cardiovascular disease in World War II veteran twins. Twin Res 2004, 7:571-577.
• [195]Sakkas GK, Karatzaferi C: Hemodialysis fatigue: just "simple" fatigue or a syndrome on its own right? Front Physiol 2012, 3:306.
• [196]Kuo SY, Yang YL, Kuo PC, Tseng CM, Tzeng YL: Trajectories of depressive symptoms and fatigue among postpartum women. J Obstet Gynecol Neonatal Nurs 2012, 41:216-226.
• [197]Wichers MC, Kenis G, Koek GH, Robaeys G, Nicolson NA, Maes M: Interferon-alpha-induced depressive symptoms are related to changes in the cytokine network but not to cortisol. J Psychosom Res 2007, 62:207-214.
• [198]Nashan D, Reuter K, Mohr P, Agarwala SS: Understanding and managing interferon-α-related fatigue in patients with melanoma. Melanoma Res 2012, 22:415-423.
• [199]Maes M, Leunis JC: Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from Gram-negative bacteria. Neuro Endocrinol Lett 2008, 29:902-910.
• [200]Kang HK, Natelson BH, Mahan CM, Lee KY, Murphy FM: Post-traumatic stress disorder and chronic fatigue syndrome-like illness among Gulf War veterans: a population-based survey of 30,000 veterans. Am J Epidemiol 2003, 57:141-148.
• [201]Maes M, Van Bockstaele DR, Gastel A, Song C, Schotte C, Neels H, DeMeester I, Scharpe S, Janca A: The effects of psychological stress on leukocyte subset distribution in humans: evidence of immune activation. Neuropsychobiology 1999, 39:1-9.
• [202]Berkovitz S, Ambler G, Jenkins M, Thurgood S: Serum 25-hydroxy vitamin D levels in chronic fatigue syndrome: a retrospective survey. Int J Vitam Nutr Res 2009, 79:250-254.
• [203]Chen Y, Kong J, Sun T, Li G, Szeto FL, Liu W, Deb DK, Wang Y, Zhao Q, Thadhani R, Li YC: 1,25-Dihydroxyvitamin D3 suppresses inflammation-induced expression of plasminogen activator inhibitor-1 by blocking nuclear factor-κB activation. Arch Biochem Biophys 2011, 507:241-247.
• [204]Fukuda S, Hashimoto R, Ohi K, Yamaguti K, Nakatomi Y, Yasuda Y, Kamino K, Takeda M, Tajima S, Kuratsune H, Nishizawa Y, Watanabe Y: A functional polymorphism in the disrupted-in schizophrenia 1 gene is associated with chronic fatigue syndrome. Life Sci 2010, 86:722-725.
• [205]Young-Pearse TL, Suth S, Luth ES, Sawa A, Selkoe DJ: Biochemical and functional interaction of DISC1 and APP regulates neuronal migration during mammalian cortical development. Neurosci 2010, 30:10431-10440.
• [206]Dietert RR, Dietert JM: Possible role for early-life immune insult including developmental immunotoxicity in chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME). Toxicology 2008, 247:61-72.