Age-specific prevalence of human papilloma virus infection among Nigerian women

BMC Public Health

Clement A Adebamowo³  Cosette M Wheeler¹  Richard Offiong²  Olayinka B Olaniyan⁵  Eileen O Dareng⁴  Ayo O Famooto⁴  Sally N Akarolo-Anthony⁴ 

[1] Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA;University of Abuja Teaching Hospital, Gwagwalada, Nigeria;Institute of Human Virology and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA;Office of Strategic Information and Research Department, Institute of Human Virology Nigeria, 252 Herbert Macaulay Way, Abuja, Nigeria;Department of Obstetrics and Gynecology, National Hospital, Abuja, Nigeria

关键词: Nigeria;    Prevalence;    HPV infection;   

Others  :  1129074
DOI  :  10.1186/1471-2458-14-656

 received in 2013-05-28, accepted in 2014-06-04,  发布年份 2014

【 摘 要 】

Background

Inconsistent trends in HPV prevalence by age have been described in Africa. We examined the age prevalence pattern and distribution of 37 HPV-DNA types among urban Nigerian women.

Methods

The study population was a sample of 278 women who presented to cervical cancer screening programs in Abuja, Nigeria, between April and August 2012. Using a nurse administered questionnaire, information on demographic characteristics and risk factors of cervical cancer was collected and samples of cervical exfoliated cells were obtained from all participants. Roche Linear Array HPV Genotyping Test® was used to characterize prevalent HPV and log-binomial regression models were used to examine the association between potential correlates and the prevalence of HPV infection.

Results

The mean age (SD) of the women enrolled was 38 (8) years. The overall prevalence of HPV was 37%. HPV 35 was the most prevalent HPV type in the study population. Among women age ≤ 30 years, 52% had HPV infection compared to 23% of those women who were older than 45 years (p = 0.006). We observed a significant linear association between age and the prevalence of HPV infections. The prevalence ratio (PR) and 95% confidence interval (CI) was 2.26 (1.17, 4.34) for any HPV infection, 3.83 (1.23, 11.94) for Group 1 HPV (definite carcinogens), and 2.19 (0.99, 4.84) for Group 2a or 2b HPV (probable or possible carcinogens) types, among women aged 18–30 years, compared to women who were older than 45 years.

Conclusion

The prevalence of HPV infection was highest among younger women and decreased steadily with age among this population of urban Nigerian women.

【 授权许可】

   
2014 Akarolo-Anthony et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Hausen H: Papillomavirus infections - a major cause of human cancers. Biochim Biophys Acta 1996, 1288:F55-F78.
• [2]Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, Vignat J, Ferlay J, Bray F, Plummer M, Franceschi S: Global burden of human papillomavirus and related diseases. Vaccine 2012, 30(Suppl 5):F12-F23.
• [3]Baseman JG, Koutsky LA: The epidemiology of human papillomavirus infections. J Clin Virol 2005, 32(Suppl 1):S16-S24.
• [4]Dunne EF, Unger ER, Sternberg M, McQuillan G, Swan DC, Patel SS, Markowitz LE: Prevalence of HPV infection among females in the United States. JAMA 2007, 297:813-819.
• [5]Jacobs MV, Walboomers JM, Snijders PJ, Voorhorst FJ, Verheijen RH, Fransen-Daalmeijer N, Meijer CJ: Distribution of 37 mucosotropic HPV types in women with cytologically normal cervical smears: the age-related patterns for high-risk and low-risk types. Int J Cancer 2000, 87:221-227.
• [6]Castellsague X, Schneider A, Kaufmann AM, Bosch FX: HPV vaccination against cervical cancer in women above 25 years of age: key considerations and current perspectives. Gynecol Oncol 2009, 115:S15-S23.
• [7]Smith JS, Melendy A, Rana RK, Pimenta JM: Age-specific prevalence of infection with human papillomavirus in females: a global review. J Adolesc Health 2008, 43:S5-S25. S25 e21-41
• [8]Temmerman M, Tyndall MW, Kidula N, Claeys P, Muchiri L, Quint W: Risk factors for human papillomavirus and cervical precancerous lesions, and the role of concurrent HIV-1 infection. Int J Gynaecol Obstet 1999, 65:171-181.
• [9]Serwadda D, Wawer MJ, Shah KV, Sewankambo NK, Daniel R, Li C, Lorincz A, Meehan MP, Wabwire-Mangen F, Gray RH: Use of a hybrid capture assay of self-collected vaginal swabs in rural Uganda for detection of human papillomavirus. J Infect Dis 1999, 180:1316-1319.
• [10]Womack SD, Chirenje ZM, Blumenthal PD, Gaffikin L, McGrath JA, Chipato T, Ngwalle E, Shah KV: Evaluation of a human papillomavirus assay in cervical screening in Zimbabwe. BJOG 2000, 107:33-38.
• [11]Thomas JO, Herrero R, Omigbodun AA, Ojemakinde K, Ajayi IO, Fawole A, Oladepo O, Smith JS, Arslan A, Munoz N, Snijders PJ, Meijer CJ, Franceschi S: Prevalence of papillomavirus infection in women in Ibadan, Nigeria: a population-based study. Br J Cancer 2004, 90:638-645.
• [12]Castellsague X, Menendez C, Loscertales MP, Kornegay JR, dos Santos F, Gomez-Olive FX, Lloveras B, Abarca N, Vaz N, Barreto A, Bosch FX, Alonso P: Human papillomavirus genotypes in rural Mozambique. Lancet 2001, 358:1429-1430.
• [13]Xi LF, Toure P, Critchlow CW, Hawes SE, Dembele B, Sow PS, Kiviat NB: Prevalence of specific types of human papillomavirus and cervical squamous intraepithelial lesions in consecutive, previously unscreened, West-African women over 35 years of age. Int J Cancer 2003, 103:803-809.
• [14]Kuhn L, Denny L, Pollack A, Lorincz A, Richart RM, Wright TC: Human papillomavirus DNA testing for cervical cancer screening in low-resource settings. J Natl Cancer Inst 2000, 92:818-825.
• [15]Clarke MA, Gage JC, Ajenifuja KO, Wentzensen NA, Adepiti AC, Wacholder S, Burk RD, Schiffman M: A population-based, cross-sectional study of age-specific risk factors for high risk human papillomavirus prevalence in rural Nigeria. Infect Agent Cancer 2011, 6:12. BioMed Central Full Text
• [16]Gage JC, Ajenifuja KO, Wentzensen NA, Adepiti AC, Eklund C, Reilly M, Hutchinson M, Wacholder S, Harford J, Soliman AS, Burk RD, Schiffman M: The age-specific prevalence of human papillomavirus and risk of cytologic abnormalities in rural Nigeria: implications for screen-and-treat strategies. Int J Cancer 2012, 130:2111-2117.
• [17]Wall SR, Scherf CF, Morison L, Hart KW, West B, Ekpo G, Fiander AN, Man S, Gelder CM, Walraven G, Borysiewicz LK: Cervical human papillomavirus infection and squamous intraepithelial lesions in rural Gambia, West Africa: viral sequence analysis and epidemiology. Br J Cancer 2005, 93:1068-1076.
• [18]Veldhuijzen NJ, Braunstein SL, Vyankandondera J, Ingabire C, Ntirushwa J, Kestelyn E, Tuijn C, Wit FW, Umutoni A, Uwineza M, Crucitti T, van de Wijgert JH: The epidemiology of human papillomavirus infection in HIV-positive and HIV-negative high-risk women in Kigali, Rwanda. BMC Infect Dis 2011, 11:333. BioMed Central Full Text
• [19]NPC: Nigeria Demographic and Health Survey. In Book Nigeria Demographic and Health Survey. City; 2008.
• [20]Castle PE, Sadorra M, Garcia F, Holladay EB, Kornegay J: Pilot study of a commercialized human papillomavirus (HPV) genotyping assay: comparison of HPV risk group to cytology and histology. J Clin Microbiol 2006, 44:3915-3917.
• [21]Coutlee F, Rouleau D, Petignat P, Ghattas G, Kornegay JR, Schlag P, Boyle S, Hankins C, Vezina S, Cote P, Macleod J, Voyer H, Forest P, Walmsley S, Franco E: Enhanced detection and typing of human papillomavirus (HPV) DNA in anogenital samples with PGMY primers and the Linear array HPV genotyping test. J Clin Microbiol 2006, 44:1998-2006.
• [22]Stevens MP, Garland SM, Tabrizi SN: Validation of an automated detection platform for use with the roche linear array human papillomavirus genotyping test. J Clin Microbiol 2008, 46:3813-3816.
• [23]van Hamont D, van Ham MA, Bakkers JM, Massuger LF, Melchers WJ: Evaluation of the SPF10-INNO LiPA human papillomavirus (HPV) genotyping test and the roche linear array HPV genotyping test. J Clin Microbiol 2006, 44:3122-3129.
• [24]Schiffman M, Clifford G, Buonaguro FM: Classification of weakly carcinogenic human papillomavirus types: addressing the limits of epidemiology at the borderline. Infect Agent Cancer 2009, 4:8. BioMed Central Full Text
• [25]Okolo C, Franceschi S, Adewole I, Thomas JO, Follen M, Snijders PJ, Meijer CJ, Clifford GM: Human papillomavirus infection in women with and without cervical cancer in Ibadan, Nigeria. Infect Agent Cancer 2010, 5:24. BioMed Central Full Text
• [26]De Vuyst H, Steyaert S, Van Renterghem L, Claeys P, Muchiri L, Sitati S, Vansteelandt S, Quint W, Kleter B, Van Marck E, Temmerman M: Distribution of human papillomavirus in a family planning population in nairobi, kenya. Sex Transm Dis 2003, 30:137-142.
• [27]Hanisch RA, Sow PS, Toure M, Dem A, Dembele B, Toure P, Winer RL, Hughes JP, Gottlieb GS, Feng Q, Kiviat NB, Hawes SE: Influence of HIV-1 and/or HIV-2 infection and CD4 count on cervical HPV DNA detection in women from Senegal, West Africa. J Clin Virol 2013, 58:696-702.
• [28]Akarolo-Anthony SN, Al-Mujtaba M, Famooto AO, Dareng EO, Olaniyan OB, Offiong R, Wheeler CM, Adebamowo CA: HIV associated high-risk HPV infection among Nigerian women. BMC Infect Dis 2013, 13:521. BioMed Central Full Text
• [29]Wee CC, Huang A, Huskey KW, McCarthy EP: Obesity and the likelihood of sexual behavioral risk factors for HPV and cervical cancer. Obesity (Silver Spring) 2008, 16:2552-2555.