Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers

BMC Genomics

Pamela Wiener²  Sarah C Blott¹  Dylan N Clements³  Ricardo Pong-Wong²  John A Woolliams²  Enrique Sánchez-Molano² 

[1] School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire LE12 5RD, UK;The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, Scotland, UK;Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG Scotland, UK

关键词: Genomic selection;    GWAS;    QTL;    Norberg Angle;    Labrador Retriever;    Canine hip dysplasia;   

Others  :  1139350
DOI  :  10.1186/1471-2164-15-833

 received in 2014-04-10, accepted in 2014-09-23,  发布年份 2014

【 摘 要 】

Background

Canine hip dysplasia (CHD) is characterised by a malformation of the hip joint, leading to osteoarthritis and lameness. Current breeding schemes against CHD have resulted in measurable but moderate responses. The application of marker-assisted selection, incorporating specific markers associated with the disease, or genomic selection, incorporating genome-wide markers, has the potential to dramatically improve results of breeding schemes. Our aims were to identify regions associated with hip dysplasia or its related traits using genome and chromosome-wide analysis, study the linkage disequilibrium (LD) in these regions and provide plausible gene candidates. This study is focused on the UK Labrador Retriever population, which has a high prevalence of the disease and participates in a recording program led by the British Veterinary Association (BVA) and The Kennel Club (KC).

Results

Two genome-wide and several chromosome-wide QTLs affecting CHD and its related traits were identified, indicating regions related to hip dysplasia.

Conclusion

Consistent with previous studies, the genetic architecture of CHD appears to be based on many genes with small or moderate effect, suggesting that genomic selection rather than marker-assisted selection may be an appropriate strategy for reducing this disease.

【 授权许可】

   
2014 Sánchez-Molano et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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