期刊论文详细信息
BMC Gastroenterology
Factors impacting physicians’ decisions to prevent variceal hemorrhage
Liana Fraenkel2  Guadalupe Garcia-Tsao2  Loren Laine2  Salvador Augustin2  John FP Bridges1  Kathleen Yan2 
[1] Department of Health Policy and Management, John Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;Yale University School of Medicine, New Haven, Connecticut and VA Connecticut Health Care System, West Haven, CT, USA
关键词: Best worst scaling;    Discrete choice;    Treatment preferences;    Variceal hemorrhage;   
Others  :  1211533
DOI  :  10.1186/s12876-015-0287-1
 received in 2014-12-15, accepted in 2015-04-27,  发布年份 2015
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【 摘 要 】

Background

Reasons underlying the variability of physicians’ preferences for non-selective beta-blockers (BBs) and endoscopic variceal ligation (EVL) to prevent a first variceal bleed have not been empirically studied. Our aims were to examine whether 1) gastroenterologists can be classified into distinct subgroups based on how they prioritize specific treatment attributes and 2) physician characteristics are associated with treatment preference.

Methods

We surveyed physicians to determine their preferred treatment for a standardized patient with large varices and examined the influence of treatment characteristics on physicians’ decision making using best-worst scaling. Latent class analysis was used to examine whether physicians could be classified into groups with similar decision-making styles.

Results

110 physicians were interviewed (participation rate 39%). The majority spent two or more days a week performing endoscopies and had practices comprising less than 25% of patients with liver disease. Latent class analysis demonstrated that physicians could be classified into at least two distinct groups. Most (n = 80, Group 1) were influenced solely by the ability to visually confirm eradication of varices. In contrast, members of Group 2 (n = 30) were influenced by the side effects and mechanism of action of BBs. Group 1 members were more likely to have practices that included fewer patients with liver disease and more likely to choose options including EVL (p = 0.01 for both).

Conclusions

Among physicians, where the majority performs endoscopy on two or more days per week, most prefer prevention strategies which include EVL. This may be due to the strong appeal of being able to visualize eradication of varices.

【 授权许可】

   
2015 Yan et al.; licensee BioMed Central.

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【 参考文献 】
  • [1]Garcia-Tsao G, Groszmann RJ, Fisher RL, Conn HO, Atterbury CE, Glickman M: Portal pressure, presence of gastroesophageal varices and variceal bleeding. Hepatology 1985, 5:419-24.
  • [2]Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W: Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology 2007, 46:922-38.
  • [3]D'Amico G, Pagliaro L, Bosch J: Pharmacological treatment of portal hypertension: an evidence-based approach. Sem Liv Dis 1999, 19:475-505.
  • [4]Villanueva C, Aracil C, Colomo A, Hernández-Gea V, López-Balaguer JM, Alvarez-Urturi C, et al.: Acute hemodynamic response to beta-blockers and prediction of long-term outcome in primary prophylaxis of variceal bleeding. Gastroenterology 2009, 137:119-28.
  • [5]Gluud LL, Krag A: Banding ligation versus beta-blockers for primary prevention in oesophageal varices in adults. Cochrane Database Syst Rev 2012, 8:CD004544.
  • [6]Bai M, Qi X, Yang M, Han G, Fan D: Combined therapies versus monotherapies for the first variceal bleeding in patients with high-risk varices: a meta-analysis of randomized controlled trials. J Gastroenterol Hepatol 2014, 29:442-52.
  • [7]de Franchis R: Endoscopy critics vs. endoscopy enthusiasts for primary prophylaxis of variceal bleeding. Hepatology 2006, 43:24-6.
  • [8]Jensen DM: Outcomes, effectiveness, tolerability, and direct costs of prophylactic variceal treatments. Hepatology 2006, 43:197-8.
  • [9]Longacre AV, Imaeda A, Garcia-Tsao G, Fraenkel L: A pilot project examining the predicted preferences of patients and physicians in the primary prophylaxis of variceal hemorrhage. Hepatology 2008, 47:169-76.
  • [10]Finn A, Louviere JJ: Determining the appropriate response to evidence of public concern: the case of food safety. J Public Policy Marketing 1992, 11:12-25.
  • [11]Bridges JF, Joy S, Gallego G, Blauvelt BM, Geschwind JF, Pawlik T: Priorities for hepatocellular carcinoma (HCC) control: a comparison of policy needs in five European countries. J Comp Pol Anal 2012, 14:352-68.
  • [12]Imaeda A, Bender D, Fraenkel L: What is most important to patients when deciding about colorectal screening? J Gen Intern Med 2010, 25:688-93.
  • [13]Najafzadeh M, Lynd LD, Davis JC, Bryan S, Anis A, Marra M, et al.: Barriers to integrating personalized medicine into clinical practice: a best-worst scaling choice experiment. Genet Med 2012, 14:520-6.
  • [14]Ratcliffe J, Flynn T, Terlich F, Stevens K, Brazier J, Sawyer M: Developing adolescent-specific health state values for economic evaluation: an application of profile case best-worst scaling to the Child Health Utility 9D. PharmacoEconomics 2012, 30:713-27.
  • [15]Youden WJ: Use of incomplete block replications in estimating tobacco-mosaic virus: contributions. Boyce Thompson Inst Plant Res 1937, 8:41-8.
  • [16]Youden WJ: Experimental designs to increase accuracy of greenhouse studies: contributions. Boyce Thompson Inst Plant Res 1940, 11:219-28.
  • [17]Orme B. Hierarchical Bayes regression analysis: technical paper. Technical Paper Series. Sequim: Sawtooth Software; Available at www.sawtoothsoftware.com. Last Accessed 3/5/2015.
  • [18]de Franchis R: Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol 2010, 53:762-8.
  • [19]Thiele M, Krag A, Rohde U, Gluud LL: Meta-analysis: banding ligation and medical interventions for the prevention of rebleeding from oesophageal varices. Aliment Pharmacol Ther 2012, 35:1155-65.
  • [20]Lugtenberg M, Burgers JS, Besters CF, Han D, Westert GP: Perceived barriers to guideline adherence: a survey among general practitioners. BMC Fam Pract 2011, 12:98. BioMed Central Full Text
  • [21]Lugtenberg M, Zegers-van Schaick JM, Westert GP, Burgers JS: Why don't physicians adhere to guideline recommendations in practice? An analysis of barriers among Dutch general practitioners. Implement Sci 2009, 4:54. BioMed Central Full Text
  • [22]Keil FC: Explanation and understanding. Annu Rev Psychol 2006, 57:227-54.
  • [23]Trout JD: The psychology of scientific explanation. Philosophy Compass 2007, 2:564-91.
  • [24]Flynn TN: Valuing citizen and patient preferences in health: recent developments in three types of best-worst scaling. Expert Rev Pharmacoecon Outcomes Res 2010, 10:259-67.
  • [25]Flynn TN, Louviere JJ, Peters TJ, Coast J: Best-worst scaling: what it can do for health care research and how to do it. J Health Econ 2007, 26:171-89.
  • [26]Gallego G, Bridges JF, Flynn T, Blauvelt BM, Niessen LW: Using best-worst scaling in horizon scanning for hepatocellular carcinoma technologies. Int J Technol Assess Health Care 2012, 28:339-46.
  • [27]Louviere JJ, Flynn TN: Using best-worst scaling choice experiments to measure public perceptions and preferences for healthcare reform in Australia. Patient 2010, 3:275-83.
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