QRS pattern and improvement in right and left ventricular function after cardiac resynchronization therapy: a radionuclide study

BMC Cardiovascular Disorders

Giuseppe Boriani²  Eric Fleury¹  Huberdine Foulkes¹  Cristian Martignani²  Igor Diemberger²  Henri Sunthorn¹  Mauro Biffi²  Francesco Fallani²  Gilberto Gavaruzzi³  Cinzia Valzania²  Haran Burri¹  Giulia Domenichini¹ 

[1] Cardiology Service, University Hospital of Geneva, Geneva, Switzerland;Institute of Cardiology, University of Bologna, Via Massarenti 9, Bologna 40138, Italy;Department of Nuclear Medicine, S. Orsola-Malpighi Hospital, Bologna, Italy

关键词: QRS morphology;    Nuclear angiography;    Dyssynchrony;    Right ventricular ejection fraction;    Left ventricular ejection fraction;    Cardiac resynchronization therapy;   

Others  :  1085090
DOI  :  10.1186/1471-2261-12-27

 received in 2011-10-20, accepted in 2012-04-11,  发布年份 2012

【 摘 要 】

Background

Predicting response to cardiac resynchronization therapy (CRT) remains a challenge. We evaluated the role of baseline QRS pattern to predict response in terms of improvement in biventricular ejection fraction (EF).

Methods

Consecutive patients (pts) undergoing CRT implantation underwent radionuclide angiography at baseline and at mid-term follow-up. The relationship between baseline QRS pattern and mechanical dyssynchrony using phase analysis was evaluated. Changes in left and right ventricular EF (LVEF and RVEF) were analyzed with regard to baseline QRS pattern.

Results

We enrolled 56 pts, 32 with left bundle branch block (LBBB), 4 with right bundle branch block (RBBB) and 20 with non-specific intraventricular conduction disturbance (IVCD). A total of 48 pts completed follow-up. LBBB pts had significantly greater improvement in LVEF compared to RBBB or non-specific IVCD pts (+9.6 ± 10.9% vs. +2.6 ± 7.6%, p = 0.003). Response (defined as ≥ 5% increase in LVEF) was observed in 68% of LBBB vs. 24% of non-specific IVCD pts (p = 0.006). None of the RBBB pts were responders. RVEF was significantly improved in LBBB (+5.0 ± 9.0%, p = 0.007), but not in non-specific IVCD and RBBB pts (+0.4 ± 5.8%, p = 0.76). At multivariate analysis, LBBB was the only predictor of LVEF response (OR, 7.45; 95% CI 1.80-30.94; p = 0.006), but not QRS duration or extent of mechanical dyssynchrony.

Conclusions

Presence of a LBBB is a marker of a positive response to CRT in terms of biventricular improvement. Pts with non-LBBB pattern show significantly less benefit from CRT than those with LBBB.

【 授权许可】

   
2012 Domenichini et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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