The CCR5Δ32 allele is not a major predisposing factor for severe H1N1pdm09 infection

BMC Research Notes

Andrea Gori¹  Mario Clerici³  Guglielmo Migliorino¹  Marianna Rossi¹  Chiara Pontremoli²  Rachele Cagliani²  Manuela Sironi² 

[1] “San Gerardo” Hospital, University of Milano-Bicocca, 20900 Monza, Italy;Scientific Institute IRCCS E. MEDEA, Bioinformatics, 23842 Bosisio Parini, Italy;Don C. Gnocchi Foundation ONLUS, IRCCS, 20148 Milan, Italy

关键词: Disease severity;    CCR5Δ32;    H1N1pdm09 infection;   

Others  :  1131695
DOI  :  10.1186/1756-0500-7-504

 received in 2014-06-12, accepted in 2014-07-31,  发布年份 2014

【 摘 要 】

Background

Host genetic factors are thought to modulated the severity of disease caused by infection with the 2009 H1N1 pandemic influenza virus (H1N1pdm09). The human CCR5 gene encodes a cytokine receptor important for cell-mediated immune response against H1N1pdm09. A 32-bp polymorphic deletion in the coding sequence of CCR5, the so-called CCR5Δ32 allele, segregates in populations of European ancestry with a frequency of 8-15%. A high proportion of CCR5Δ32 heterozygotes was reported in a sample of white Canadian critically-ill H1N1pdm09 infected subjects, suggesting an association with disease severity.

Methods

We recruited 29 H1N1pdm09 infected subjects from Southern Europe (mostly Italians) with a wide clinical spectrum of disease symptoms; the sample included 7 subjects who developed acute respiratory distress syndrome requiring extracorporeal membrane oxygenation. The CCR5Δ32 variant was genotyped in all subjects.

Results

The CCR5Δ32 allele was found in one single subject, who developed a very mild form and was not hospitalized.

Conclusions

The CCR5Δ32 allele was not found to be associated with the risk of H1N1pdm09 infection or with a severe disease course.

【 授权许可】

   
2014 Sironi et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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