Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF)

BMC Medicine

André Briend²  Indi Trehan⁷  Mark Manary⁸  Lei Liu⁹  Kelsey D Jones⁵  Philip C Calder⁴  James A Berkley¹  Paluku Bahwere⁶  Peter Akomo³  J Thomas Brenna⁹ 

[1] Nuffield Department of Clinical Medicine, Centre for Tropical Medicine & Global Health, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, UK;Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 30, Frederiksberg, DK-1958, Denmark;Valid Nutrition, Cuibín Farm, Derry Duff, Bantry Co., Cork, Republic of Ireland;Faculty of Medicine, University of Southampton, Institute of Developmental Sciences Building (MP887), Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK;Centre for Global Health Research and Section of Paediatrics, Imperial College, Norfolk Place, London, UK;Valid International, 35 Leopold Street, Oxford OX4 1TW, UK;University of Malawi College of Medicine, P/Bag 360 Chichiri, Blantyre 3, Malawi;Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO, USA;Division of Nutritional Sciences, Savage Hall, Cornell University, Ithaca 14850, NY, USA

关键词: Severe acute malnutrition;    Ready-to-use therapeutic foods;    Omega-3 fatty acids;    High oleic peanuts;    Docosahexaenoic acid supplementation;   

Others  :  1203871
DOI  :  10.1186/s12916-015-0352-1

 received in 2015-04-23, accepted in 2015-04-23,  发布年份 2015

【 摘 要 】

Ready-to-use therapeutic foods (RUTFs) are a key component of a life-saving treatment for young children who present with uncomplicated severe acute malnutrition in resource limited settings. Increasing recognition of the role of balanced dietary omega-6 and omega-3 polyunsaturated fatty acids (PUFA) in neurocognitive and immune development led two independent groups to evaluate RUTFs. Jones et al. (BMC Med 13:93, 2015), in a study in BMC Medicine, and Hsieh et al. (J Pediatr Gastroenterol Nutr 2015), in a study in the Journal of Pediatric Gastroenterology and Nutrition, reformulated RUTFs with altered PUFA content and looked at the effects on circulating omega-3 docosahexaenoic acid (DHA) status as a measure of overall omega-3 status. Supplemental oral administration of omega-3 DHA or reduction of RUTF omega-6 linoleic acid using high oleic peanuts improved DHA status, whereas increasing omega-3 alpha-linolenic acid in RUTF did not. The results of these two small studies are consistent with well-established effects in animal studies and highlight the need for basic and operational research to improve fat composition in support of omega-3-specific development in young children as RUTF use expands.

Please see related article: http://www.biomedcentral.com/1741-7015/13/93 webcite

【 授权许可】

   
2015 Brenna et al.; licensee BioMed Central.

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