Methylenetetrahydrofolate reductase C677T polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese males

BMC Medical Genetics

Yong Huo⁶  Xin Xu³  Hongbing Shen^1,10  Fanfan Hou³  Xiping Xu³  Lisheng Liu⁵  Ningling Sun⁹  Binyan Wang^1,11  Fangfang Fan⁶  Yan Zhang⁶  Jianping Li⁶  Liming Sun⁴  Houxun Xing⁷  Yefeng Cai¹  Yunqing Cai^1,10  Mingli He⁸  Genfu Tang²  Qing Dong^1,10 

[1] Department of Neurology, Guangdong Traditional Chinese Medicine Hospital, Guangzhou, China;School of Health Administration, Anhui Medical University, Hefei, China;Institute of Nephrology, Southern Medical University, Guangzhou, China;Department of Cardiology, Second People’s Hospital, Lianyungang, China;Division of Hypertension, Fu-wai Hospital, Beijing, China;Department of Cardiology, Peking University First Hospital, Beijing, China;Lianyungang Center for Advanced Research in Cardiovascular Diseases, Lianyungang, China;Department of Neurology, First People’s Hospital, Lianyungang, China;Department of Cardiology, Peking University People’s Hospital, Beijing, China;Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China;Institute of Biomedicine, Shenzhen University, Guangzhou, China

关键词: CKD;    eGFR;    MTHFR C677T polymorphism;   

Others  :  1177811
DOI  :  10.1186/1471-2350-13-74

 received in 2011-12-14, accepted in 2012-04-30,  发布年份 2012

【 摘 要 】

Background

Plasma level of total homocysteine (tHcy) is negatively correlated with kidney function in general population. However, the causal mechanism of this correlation is poorly understood. The purpose of this study is to investigate the association of methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, which is a major genetic determinant of the plasma tHcy level, with estimated glomerular filtration rate (eGFR) in Chinese.

Methods

A total of 18 814 hypertensive patients (6 914 males, 11 900 females) were included in the study.

Results

Association between the eGFR and MTHFR C677T genotype was examined by sex-specific regression analyses. In males, TT genotype was associated with 1.37 ml/min/1.73 m² decrease in eGFR (p = 0.004) and with an increased risk (OR = 1.32, p = 0.008) for the lowest quintile of eGFR after adjusting for age, BMI, and blood pressures. However, such association was not observed in females (p > 0.05). This association suggests MTHFR C677T polymorphism may play a role in the regulation of eGFR in males.

Conclusions

MTHFR 677 T is a risk allele for decreased kidney function in Chinese males, implicating this gene in the pathogenesis of chronic kidney disease (CKD).

【 授权许可】

   
2012 Dong et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1 .

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