Coffee consumption and NAFLD: a community based study on 1223 subjects

BMC Research Notes

Wolfgang Kratzer³  Bernhard Otto Boehm⁴  Wolfgang Koenig²  Mark M. Haenle³  Suemeyra Oeztuerk³  Richard A. Mason⁵  Pia C. Niedermayer³  Tilmann Graeter¹ 

[1] Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Albert-Einstein-Allee 23, Ulm, 89081, Germany;Department of Internal Medicine II, University Hospital Ulm, Albert-Einstein-Allee 23, Ulm, 89081, Germany;Department of Internal Medicine I, University Hospital Ulm, Albert-Einstein-Allee 23, Ulm, 89081, Germany;Imperial College London, London, UK;Louis Stokes Clevel and Department of Veterans Affairs Medical Center, 10700 East Boulevard, Cleveland 44106, OH, USA

关键词: Population-based cross-sectional study;    Alanine aminotransferase;    Fatty liver;    Hepatic steatosis;    Caffeine;   

Others  :  1232828
DOI  :  10.1186/s13104-015-1645-3

 received in 2015-06-30, accepted in 2015-10-28,  发布年份 2015

【 摘 要 】

Background

Objective of the present cross-sectional study was to investigate the impact of caffeine consumption on fatty liver and serum alanine aminotransferase (ALT) concentrations in a random population sample.

Methods

All subjects (n = 1452; 789 women, 663 men; average age 42.3 ± 12.8 years) underwent ultrasonographic examination of the liver and completed a standardized questionnaire regarding personal and lifestyle data, in particular relating to coffee consumption and past medical history. In addition, anthropometric data were documented and laboratory examinations performed. Statistical interpretation of the data was performed descriptively and by means of bivariate and multivariate analysis.

Results

Data of the present study demonstrated a significant association between hepatic steatosis male gender (p < 0.0001), advanced age (p < 0.0001) and elevated body-mass index (BMI; p < 0.0001). No association between caffeine consumption and fatty liver was identified. An association between caffeine consumption and elevated serum ALT concentrations was not identified.

Conclusions

The findings of the present study provide no evidence for an association between caffeine consumption and either the prevalence of hepatic steatosis or serum ALT concentrations.

【 授权许可】

   
2015 Graeter et al.

【 图 表 】

Fig.1.

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