Do women with statin-related myalgias have low vitamin D levels?

BMC Research Notes

C. Noel Bairey Merz¹  Jo-Ann Eastwood¹  Galen Cook-Wiens¹  Greg Lentz¹  Talya Waldman¹  Puja K. Mehta¹  Chrisandra Shufelt¹  Megha Agarwal¹  Margo Minissian¹ 

[1] The Barbra Streisand Women’s Heart Center, Cedars-Sinai Heart Institute, 127 San Vicente Blvd AHSP Suite A9306, Los Angeles 90048, CA, USA

关键词: Alternative statin dosing;    Statin intolerance;    Myalgia;    Statin;    Vitamin D;   

Others  :  1230132
DOI  :  10.1186/s13104-015-1356-9

 received in 2014-01-24, accepted in 2015-08-17,  发布年份 2015

【 摘 要 】

Background

Statin intolerance is often due to myalgias. Severe vitamin D deficiency is characterized by musculoskeletal pain. We hypothesized that statin-intolerance is associated with vitamin D deficiency.

Objectives

To determine whether there is an association between statin-intolerance and vitamin D deficiency in a retrospective observational analysis.

Methods

We evaluated 20 female patients with prior myalgia-related daily dose statin intolerance on an alternative day statin dosing protocol of twice weekly for 4 weeks followed by advancement to daily dosing, as tolerated. Fasting baseline and follow-up lipid and 25-hydroxy-vitamin D (25-OHD) levels were obtained by chart review.

Results

The group median age was 61 ± 13 years old and BMI was 27 ± 7 kg/m ² . Women who remained on alternative day statin dosing (n = 16) compared to women on daily dosing (n = 4) had a significantly lower group mean 25-OHD (mean 29 ± 11.23 vs. 47.5 ± 23.53 ng/ml p = 0.0307 respectively).

Conclusions

In women with prior myalgia-related statin intolerance, vitamin D levels were significantly lower in women who remained on alternative day dosing compared to those who were tolerant of daily dosing.

【 授权许可】

   
2015 Minissian et al.

【 图 表 】

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