BMC Infectious Diseases | |
Adherence to the cervical cancer screening program in women living with HIV in Denmark: comparison with the general population | |
Anne-Mette Lebech1  Merete Storgaard7  Marie Helleberg2  Jette Junge4  Gitte Pedersen3  Isik Somuncu Johansen6  Terese L Katzenstein2  Søren Jensen-Fangel7  Steen Ladelund5  Kristina Thorsteinsson1  | |
[1] Department of Infectious Diseases, Hvidovre Hospital, Copenhagen University Hospital, Kettegaards Allé 30, DK-2650 Hvidovre, Denmark;Department of Infectious Diseases, The National University Hospital, Rigshospitalet, Copenhagen, Denmark;Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark;Department of Pathology, Hvidovre, Copenhagen University Hospital, Hvidovre, Denmark;Clinical Research Center, Hvidovre, Copenhagen University Hospital, Copenhagen, Denmark;Department of Infectious Diseases, Odense University Hospital, Odense, Denmark;Department of Infectious Diseases, Skejby, Aarhus University Hospital, Skejby, Denmark | |
关键词: Guidelines; Attendance; Adherence; HIV; Screening; Cancer; Cervical; | |
Others : 1127819 DOI : 10.1186/1471-2334-14-256 |
|
received in 2014-01-21, accepted in 2014-04-30, 发布年份 2014 | |
【 摘 要 】
Background
Women living with HIV (WLWH) are at increased risk of invasive cervical cancer (ICC). International HIV guidelines suggest cervical screening twice the first year after HIV diagnosis and thereafter annually. Adherence to the HIV cervical screening program in Denmark is unknown.
Methods
We studied women from a population-based, nationwide HIV cohort in Denmark and a cohort of age-matched females from the general population. Screening behaviour was assessed from 1999–2010. Adjusted odds ratios (OR’s) for screening attendance in the two cohorts and potential predictors of attendance to guidelines were estimated. Pathology specimens were identified from The Danish Pathology Data Bank.
Results
We followed 1143 WLWH and 17,145 controls with no prior history of ICC for 9,509 and 157,362 person-years. The first year after HIV diagnosis 2.6% of WLWH obtained the recommended two cervical cytologies. During the different calendar intervals throughout the study period between 29-46% of WLWH followed the HIV cervical screening guidelines. Adjusted OR’s of attendance to the general population screening program for WLWH aged 30, 40 and 50 years, compared to controls, were 0.69 (95% CI: 0.56-0.87), 0.67 (0.55-0.80) and 0.84 (0.61-1.15). Predictors of attendance to the HIV cervical screening program were a CD4 count > 350 cells/μL and HIV RNA < 500 copies/mL. Calendar period after 2002 and HIV RNA < 500 copies/mL predicted attendance to the general population cervical screening program.
Conclusions
The majority of WLWH do not follow the HIV guidelines for cervical screening. We support the idea of cytology as part of an annual review and integration of HIV care and cervical screening in a single clinic setting.
【 授权许可】
2014 Thorsteinsson et al.; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
20150221120241238.pdf | 313KB | download | |
Figure 2. | 19KB | Image | download |
Figure 1. | 26KB | Image | download |
【 图 表 】
Figure 1.
Figure 2.
【 参考文献 】
- [1]Kaplan JE, Benson C, Holmes KH, Brooks JT, Pau A, Masur H: Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. MMWR Recomm Rep 2009, 58:1-207.
- [2]Spence AR, Goggin P, Franco EL: Process of care failures in invasive cervical cancer: systematic review and meta-analysis. Prev Med 2007, 45:93-106.
- [3]Abraham AG, Strickler HD, Jing Y, Gange SJ, Sterling TR, Silverberg M, et al.: Invasive cervical cancer risk among HIV-infected women: a North American multi-cohort collaboration prospective study. J Acquir Immune Defic Syndr 2012.
- [4]Franceschi S, Denny L, Irwin KL, Jeronimo J, Lopalco PL, Monsonego J, et al.: Eurogin 2010 roadmap on cervical cancer prevention. Int J Cancer 2011, 128:2765-2774.
- [5]Moyer VA: Screening for cervical cancer: U.S. Preventive services task force recommendation statement. Ann Intern Med 2012, 156:880-91. W312
- [6]Strickler HD, Burk RD, Fazzari M, Anastos K, Minkoff H, Massad LS, et al.: Natural history and possible reactivation of human papillomavirus in human immunodeficiency virus-positive women. J Natl Cancer Inst 2005, 97:577-586.
- [7]Bailey H, Thorne C, Semenenko I, Malyuta R, Tereschenko R, Adeyanova I, et al.: Cervical Screening within HIV Care: findings from an HIV-positive cohort in Ukraine. PLoS One 2012, 7:e34706.
- [8]Danso D, Lyons F, Bradbeer C: Cervical screening and management of cervical intraepithelial neoplasia in HIV-positive women. Int J STD AIDS 2006, 17:579-584.
- [9]Massad LS, Seaberg EC, Wright RL, Darragh T, Lee YC, Colie C, et al.: Squamous cervical lesions in women with human immunodeficiency virus: long-term follow-up. Obstet Gynecol 2008, 111:1388-1393.
- [10]Minkoff H, Zhong Y, Burk RD, Palefsky JM, Xue X, Watts DH, et al.: Influence of adherent and effective antiretroviral therapy use on human papillomavirus infection and squamous intraepithelial lesions in human immunodeficiency virus-positive women. J Infect Dis 2010, 201:681-690.
- [11]Clifford GM, Polesel J, Rickenbach M, Dal ML, Keiser O, Kofler A, et al.: Cancer risk in the Swiss HIV cohort study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy. J Natl Cancer Inst 2005, 97:425-432.
- [12]The Danish National Board of HealthAvailable from: http://www.sst.dk/Sundhed%20og%20forebyggelse/Tobak/Tal_og_undersoegelser/Danskernes_rygevaner/UdvilkingDec2010.aspx webcite. Accessed on March 21st 2012. Webpage in Danish. 21-3-2012. Ref Type: Internet Communication
- [13]Oster AM, Sullivan PS, Blair JM: Prevalence of cervical cancer screening of HIV-infected women in the United States. J Acquir Immune Defic Syndr 2009, 51:430-436.
- [14]Stein MD, Cunningham WE, Nakazono T, Turner BJ, Andersen RM, Bozzette SA, et al.: Screening for cervical cancer in HIV-infected women receiving care in the United States. J Acquir Immune Defic Syndr 2001, 27:463-466.
- [15]Smith ML, Chan DJ: Cervical screening rates among culturally diverse women in a specialist HIV/AIDS clinic. Int J STD AIDS 2011, 22:614-615.
- [16]Stuardo V, Agusti C, Godinez JM, Montoliu A, Torne A, Tarrats A, et al.: Human papillomavirus infection in HIV-1 infected women in Catalonia (Spain): implications for prevention of cervical cancer. PLoS One 2012, 7:e47755.
- [17]Keiser O, de Martinez TB, Wunder D, Chapuis-Taillard C, Zellweger C, Zinkernagel AS, et al.: Frequency of gynecologic follow-up and cervical cancer screening in the Swiss HIV cohort study. J Acquir Immune Defic Syndr 2006, 43:550-555.
- [18]The Danish National Board of HealthAvailable from: http://www.sst.dk/publ/Publ2007/PLAN/Kraeft/Anbef_screen_livmoderhals.pdf webcite. Article in Danish. Summary in English. Acessed on January 10th 2013. 10-1-2013. Ref Type: Internet Communication
- [19]Spence AR, Goggin P, Franco EL: Process of care failures in invasive cervical cancer: systematic review and meta-analysis. Prev Med 2007, 45:93-106.
- [20]Pedersen CB: The Danish civil registration system. Scand J Public Health 2011, 39:22-25.
- [21]Act on Research Ethics Review of Health Research Projects. http://www.cvk.sum.dk/English/actonabiomedicalresearch.aspx webcite. Accessed on July 31st 2013. 31-7-2013. Ref Type: Internet Communication
- [22]Statistics Denmark. http://www.dst.dk/da/Statistik/emner/befolkning-og-befolkningsfremskrivning/folketal.aspx webcite. Accessed on September 14th 2012. Webpage in Danish. 14-9-2012. Ref Type: Internet Communication
- [23]Statens Serum Institut. http://www.ssi.dk/Service/Sygdomsleksikon/H/AIDS%20-%20HIV.aspx webcite. Accessed on September 14th 2012. Webpage in Danish. 14-9-2012. Ref Type: Internet Communication
- [24]The Danish National Board of HealthAvailable from: http://www.sst.dk/publ/Publ2007/PLAN/Kraeft/Anbef_screen_livmoderhals.pdf webcite. Article in Danish. Summary in English. Acessed on January 10th 2013. 2013. Ref Type: Internet Communication
- [25]The Danish National Board of HealthAvailable from: http://www.sst.dk/publ/Publ2007/PLAN/Kraeft/Anbef_screen_livmoderhals.pdf webcite. Article in Danish. Summary in English. Acessed on January 10th 2013. 2013. Ref Type: Internet Communication
- [26]Obel N, Engsig FN, Rasmussen LD, Larsen MV, Omland LH, Sorensen HT: Cohort profile: the Danish HIV cohort study. Int J Epidemiol 2009, 38:1202-1206.
- [27]Erichsen R, Lash TL, Hamilton-Dutoit SJ, Bjerregaard B, Vyberg M, Pedersen L: Existing data sources for clinical epidemiology: the Danish national pathology registry and data bank. Clin Epidemiol 2010, 2:51-56.
- [28]Lynge E, Sandegaard JL, Rebolj M: The Danish national patient register. Scand J Public Health 2011, 39:30-33.
- [29]Storm HH, Michelsen EV, Clemmensen IH, Pihl J: The Danish cancer registry–history, content, quality and use. Dan Med Bull 1997, 44:535-539.
- [30]Dal ML, Franceschi S, Lise M, De' Bianchi PS, Polesel J, Ghinelli F, et al.: Self-reported history of Pap-smear in HIV-positive women in Northern Italy: a cross-sectional study. BMC Cancer 2010, 10:310. BioMed Central Full Text
- [31]Howard M, Agarwal G, Lytwyn A: Accuracy of self-reports of Pap and mammography screening compared to medical record: a meta-analysis. Cancer Causes Control 2009, 20:1-13.
- [32]Hewitt M, Devesa SS, Breen N: Cervical cancer screening among U.S. women: analyses of the 2000 national health interview survey. Prev Med 2004, 39:270.
- [33]Lim EJ, Morgan J, Fielding R: Cervical screening uptake in immunocompromised women in Waikato, New Zealand. Int J STD AIDS 2010, 21:835-836.
- [34]Carne C, McClean H, Bunting P, Wilkins E, Tucker L, Baguley S, et al.: UK national audit of sexual health care for people with HIV infection: case-notes audit. Int J STD AIDS 2007, 18:639-642.
- [35]Shah S, Montgomery H, Smith C, Madge S, Walker P, Evans H, et al.: Cervical screening in HIV-positive women: characteristics of those who default and attitudes towards screening. HIV Med 2006, 7:46-52.
- [36]Aarsrapport DKLS 2011/Annual Report DKLS 2011. https://www.sundhed.dk/content/cms/82/4682_dkls-%C3%A5rsrapport-2011-dfs-270612.pdf webcite. Accessed on January 17th 2013. Webpage in Danish. 17-1-2013. Ref Type: Internet Communication
- [37]Helleberg M, Engsig FN, Kronborg G, Larsen CS, Pedersen G, Pedersen C, et al.: Retention in a public healthcare system with free access to treatment: a Danish nationwide HIV cohort study. AIDS 2012, 26:741-748.
- [38]Keller MJ, Burk RD, Xie X, Anastos K, Massad LS, Minkoff H, et al.: Risk of cervical precancer and cancer among HIV-infected women with normal cervical cytology and no evidence of oncogenic HPV infection. JAMA 2012, 308:362-369.