Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre

BMC Gastroenterology

Márk Juhász¹  Zsolt Tulassay¹  Miklós Tóth¹  László Herszényi¹  Péter Pák²  Pál Miheller¹  Ágnes A. Csontos¹  Zsuzsanna Tóth³  Dorottya Kocsis¹ 

[1] 2nd Department of Medicine, Semmelweis University, Szentkirályi st. 46., Budapest, 1088, Hungary;Vaszary Kolos. Hospital, Gastroenterology Unit, Petőfi S. st. 26-28., Esztergom, 2500, Hungary;Peterfy S. u. Hospital, Gastroenterology Unit, Péterfy S. st. 8-20., Budapest, 1076, Hungary

关键词: Ulcerative colitis;    Crohn’s disease;    Inflammatory bowel disease;    Coeliac disease;   

Others  :  1234336
DOI  :  10.1186/s12876-015-0370-7

 received in 2015-02-14, accepted in 2015-10-08,  发布年份 2015

【 摘 要 】

Background

Celiac disease, Crohn disease and ulcerative colitis are inflammatory disorders of the gastrointestinal tract with some common genetic, immunological and environmental factors involved in their pathogenesis. Several research shown that patients with celiac disease have increased risk of developing inflammatory bowel disease when compared with that of the general population. The aim of this study is to determine the prevalence of inflammatory bowel disease in our celiac patient cohort over a 15-year-long study period.

Methods

To diagnose celiac disease, serological tests were used, and duodenal biopsy samples were taken to determine the degree of mucosal injury. To set up the diagnosis of inflammatory bowel disease, clinical parameters, imaging techniques, colonoscopy histology were applied. DEXA for measuring bone mineral density was performed on every patient.

Results

In our material, 8/245 (3,2 %) coeliac disease patients presented inflammatory bowel disease (four males, mean age 37, range 22–67), 6/8 Crohn’s disease, and 2/8 ulcerative colitis. In 7/8 patients the diagnosis of coeliac disease was made first and inflammatory bowel disease was identified during follow-up. The average time period during the set-up of the two diagnosis was 10,7 years. Coeliac disease serology was positive in all cases. The distribution of histology results according to Marsh classification: 1/8 M1, 2/8 M2, 3/8 M3a, 2/8 M3b. The distribution according to the Montreal classification: 4/6 Crohn’s disease patients are B1, 2/6 Crohn’s disease patients are B2, 2/2 ulcerative colitis patients are S2. Normal bone mineral density was detected in 2/8 case, osteopenia in 4/8 and osteoporosis in 2/8 patients.

Conclusions

Within our cohort of patients with coeliac disease, inflammatory bowel disease was significantly more common (3,2 %) than in the general population.

【 授权许可】

   
2015 Kocsis et al.

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