Characteristics and determinants of endurance cycle ergometry and six-minute walk distance in patients with COPD

BMC Pulmonary Medicine

Martijn A Spruit³  Emiel F M Wouters⁴  Ioannis Vogiatzis⁵  Frank WJM Smeenk²  Frits ME Franssen³  Lowie E Vanfleteren³  Miriam TJ Groenen³  Scott S Wagers¹  Vasileios Andrianopoulos³ 

[1] BioSci Consulting, Weg naar Geneuth 95, 3631, Maasmechelen, Limburg, Belgium;Department of Respiratory Medicine, Catharina Hospital, Eindhoven, Netherlands;Department of Research & Education, CIRO+, Centre of Expertise for Chronic Organ Failure, Hornerheide 1, 6085 NM Horn, Eindhoven, Netherlands;Department of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), P.Debyelaan 25, 6202 AZ Maastricht, Netherlands;Institute of Clinical Exercise and Health Sciences, University of the West of Scotland, Paisley PA1 2BE, Scotland, United Kingdom

关键词: COPD;    CPET;    CET;    6MWT;    Exercise;   

Others  :  862818
DOI  :  10.1186/1471-2466-14-97

 received in 2013-12-16, accepted in 2014-05-20,  发布年份 2014

【 摘 要 】

Background

Exercise tolerance can be assessed by the cycle endurance test (CET) and six-minute walk test (6MWT) in patients with Chronic Obstructive Pulmonary Disease (COPD). We sought to investigate the characteristics of functional exercise performance and determinants of the CET and 6MWT in a large clinical cohort of COPD patients.

Methods

A dataset of 2053 COPD patients (43% female, age: 66.9 ± 9.5 years, FEV₁% predicted: 48.2 ± 23.2) was analyzed retrospectively. Patients underwent, amongst others, respiratory function evaluation; medical tests and questionnaires, one maximal incremental cycle test where peak work rate was determined and two functional exercise tests: a CET at 75% of peak work rate and 6MWT. A stepwise multiple linear regression was used to assess determinants.

Results

On average, patients had impaired exercise tolerance (peak work rate: 56 ± 27% predicted, 6MWT: 69 ± 17% predicted). A total of 2002 patients had CET time of duration (CET-T_end) less than 20 min while only 51 (2.5%) of the patients achieved 20 min of CET-T_end . In former patients, the percent of predicted peak work rate achieved differed significantly between men (48 ± 21% predicted) and women (67 ± 31% predicted). In contrast, CET-T_end was longer in men (286 ± 174 s vs 250 ± 153 s, p < 0.001). Also, six minute walking distance (6MWD) was higher in men compared to women, both in absolute terms as in percent of predicted (443 m, 67%predicted vs 431 m, 72%predicted, p < 0.05). Gender was associated with the CET-T_end but BMI, FEV₁ and FRC were related to the 6MWD highlighting the different determinants of exercise performance between CET and 6MWT.

Conclusions

CET-T_end is a valuable outcome of CET as it is related to multiple clinical aspects of disease severity in COPD. Gender difference should temper the interpretation of CET.

【 授权许可】

   
2014 Andrianopoulos et al.; licensee BioMed Central Ltd.

【 图 表 】

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