期刊论文详细信息
BMC Pulmonary Medicine
Clinical outcomes associated with Staphylococcus aureus and Pseudomonas aeruginosa airway infections in adult cystic fibrosis patients
Dao Nguyen3  Simon Rousseau3  Larry C. Lands4  Danuta Radzioch2  Elias Matouk1  Joanie Bernier1  Jennifer S. Landry5  Andrea Benedetti5  Heather G. Ahlgren6 
[1] Adult CF clinic, McGill University Health Center, Montreal, Canada;Department of Human Genetics, McGill University, Montreal, Canada;Department of Medicine, McGill University Health Center Research Institute, Montreal, Canada;Department of Pediatrics, McGill University Health Center Research Institute, Montreal, Canada;Respiratory Epidemiology and Clinical Research Unit, McGill University Health Center, Montreal, Canada;Department of Medicine, McGill University, Montreal, Canada
关键词: Retrospective cohort;    Pulmonary exacerbation;    Lung function;    Pseudomonas aeruginosa;    Staphylococcus aureus;    Microbiology;    Cystic fibrosis;   
Others  :  1216157
DOI  :  10.1186/s12890-015-0062-7
 received in 2015-03-12, accepted in 2015-06-10,  发布年份 2015
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【 摘 要 】

Background

Staphylococcus aureus (SA) is the most prevalent organism infecting the respiratory tract of CF children, and remains the second most prevalent organism in CF adults. During early childhood, SA infections are associated with pulmonary inflammation and decline in FEV 1 , but their clinical significance in adult CF patients is poorly characterized.

Methods

We conducted a retrospective cross-sectional study to determine the association between airway microbiology and clinical outcomes (FEV 1 , rate of pulmonary exacerbations, CRP levels and clinical scores).

Results

In a cohort of 84 adult CF patients, 24 % were infected with SA only, 60 % were infected with PA, and 16 % had neither PA nor SA. CF patients with SA experienced fewer pulmonary exacerbations and lower CRP levels than those with PA.

Conclusion

In adult CF patients, SA infections alone, in the absence of PA, are a marker of milder disease.

【 授权许可】

   
2015 Ahlgren et al.

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