Identification of a New Delhi metallo-β-lactamase-4 (NDM-4)-producing Escherichia coli in Italy

BMC Microbiology

Anna Marchese¹  Claudio Viscoli²  Giovanni Orengo⁵  Marco Camera⁴  Francesco Ventura³  Valerio Del Bono⁴  Erika Coppo⁶ 

[1] Microbiology Unit DISC, University of Genoa, IRCCS AOU San Martino-IST, Largo R. Benzi 10, 16132 Genoa, Italy;Infectious Diseases Unit DISSAL, University of Genoa, IRCCS AOU San Martino-IST, Largo R. Benzi 10, 16132 Genoa, Italy;Rehabilitation Unit, IRCCS AOU San Martino-IST, Largo R. Benzi 10, 16132 Genoa, Italy;Infectious Diseases Unit, IRCCS AOU San Martino-IST, Largo R. Benzi 10, 16132 Genoa, Italy;Hygiene and Epidemiology Unit, IRCCS AOU San Martino-IST, Largo R. Benzi 10, 16132 Genoa, Italy;Microbiology Unit, DISC Department, University of Genoa, Largo R. Benzi 10, 16132 Genoa, Italy

关键词: Class 1 integron;    ST405;    E.coli;    Carbapenemases;   

Others  :  1140945
DOI  :  10.1186/1471-2180-14-148

 received in 2013-12-20, accepted in 2014-05-28,  发布年份 2014

【 摘 要 】

Background

During June-July 2012, six imipenem-resistant Escherichia coli isolates were isolated from two patients hospitalized in a ward of one large tertiary-care hospital in Genoa, Italy. Genetic features associated with bla_NDM-4 gene were investigated.

Results

The isolates exhibited the same PFGE profile and a multidrug-resistant (MDR) phenotype to aminoglycosides, fluoroquinolones, and β-lactams. The strains produced the NDM-4 carbapenemase and the bla_NDM-4 gene was part of the variable region of a class 1 integron. MLST analysis revealed that all isolates belonged to sequence type 405 (ST405).

Conclusions

This is the first report on the emergence of an MDR strain of E.coli producing the NDM-4 MBL in Italy.

【 授权许可】

   
2014 Coppo et al.; licensee BioMed Central Ltd.

【 图 表 】

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