Acquired Fanconi syndrome in patients with Legionella pneumonia

BMC Nephrology

Ryuichi Furuya³  Yoshihide Fujigaki²  Shiro Imokawa¹  Shinsuke Isobe²  Sayaka Ishigaki³  Hirotaka Fukasawa³  Naoko Kinoshita-Katahashi³ 

[1] Department of Respiratory Medicine, Iwata City Hospital, 512-3 Ohkubo, Iwata, Shizuoka 438-8550, Japan;Internal Medicine1, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan;Renal Division, Department of Internal Medicine, Iwata City Hospital, 512-3 Ohkubo, Iwata, Shizuoka, 438–8550, Japan

关键词: Electrolyte abnormality;    Legionella pneumonia;    Fanconi syndrome;   

Others  :  1082868
DOI  :  10.1186/1471-2369-14-171

 received in 2013-02-18, accepted in 2013-05-09,  发布年份 2013

【 摘 要 】

Background

Hyponatremia is often observed in patients with Legionella pneumonia. However, other electrolyte abnormalities are uncommon and the mechanism remains to be clarified.

Case presentation

We experienced two male cases of acquired Fanconi syndrome associated with Legionella pneumonia. The laboratory findings at admission showed hypophosphatemia, hypokalemia, hypouricemia and/or hyponatremia. In addition, they had the generalized dysfunction of the renal proximal tubules presenting decreased tubular reabsorption of phosphate (%TRP), increased fractional excretion of potassium (FEK) and uric acid (FEUA), low-molecular-weight proteinuria, panaminoaciduria and glycosuria. Therefore, they were diagnosed as Fanconi syndrome. Treatment for Legionella pneumonia with antibiotics resulted in the improvement of all serum electrolyte abnormalities and normalization of the %TRP, FEK, FEUA, low-molecular-weight proteinuria, panaminoaciduria and glycosuria, suggesting that Legionella pneumophila infection contributed to the pathophysiology of Fanconi syndrome.

Conclusion

To the best of our knowledge, this is the first report demonstrating Fanconi syndrome associated with Legionella pneumonia.

【 授权许可】

   
2013 Kinoshita-Katahashi et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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