期刊论文详细信息
BMC Gastroenterology
Autoimmune pancreatitis with colonic stenosis: an unusual complication and atypical pancreatographic finding
Hiroyuki Ono1  Kenichiro Imai1  Kimihiro Igarashi1  Yasuyuki Tanaka1  Masao Yoshida1  Yukio Yoshida1  Yoshihiro Kishida1  Hiroyuki Matsubayashi1 
[1] Division of Endoscopy, Shizuoka Cancer Center, Nagaizumi, Suntogun, Shizuoka 411-8777, Japan
关键词: Steroid therapy;    Differential diagnosis;    Colonic stenosis;    Autoimmune pancreatitis;   
Others  :  1121793
DOI  :  10.1186/1471-230X-14-173
 received in 2014-06-18, accepted in 2014-09-29,  发布年份 2014
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【 摘 要 】

Background

Type 1 autoimmune pancreatitis (AIP) often accompanies various systematic disorders such as sclerosing cholangitis, sialoadenitis, retroperitoneal fibrosis, interstitial pneumonitis and nephritis. Although rarely reported in acute pancreatitis, colonic stenosis is an uncommon complication in cases with AIP.

Case presentation

A 69-year-old Japanese man complained of abdominal pain and continuous diarrhea, resistant to intake of antimuscarinic and probiotic agents. A colonoscopy demonstrated a stenosis at the splenic flexure. Computed tomography revealed a focal enlargement of the pancreatic tail with a capsule-like rim, contacting with the descending colon. Endoscopic retrograde pancreatography (ERP) was unable to visualize the main pancreatic duct (MPD) at the pancreatic tail, despite a full contrast injection. A high serum IgG4 level (1060 mg/dL) and exclusion of pancreatic cancer by endoscopic ultrasound guided-fine needle aspiration suggested AIP, but did not fulfill the diagnostic criteria, and steroid therapy was initiated. One month after starting steroid intake, pancreatic swelling was minimized and the MPD was visualized by ERP, fulfilling the international consensus diagnostic criteria (ICDC) of AIP. Colonic stenosis was relieved and the patient’s symptoms disappeared.

Conclusion

The present case is the first report of AIP developing colonic stenosis by the inflammatory infiltration. In this case, steroid therapy was effective for the diagnosis and treatment of pancreatic mass involving the descending colon.

【 授权许可】

   
2014 Matsubayashi et al.; licensee BioMed Central Ltd.

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