BMC Research Notes | |
Retrospective case-series of Paecilomyces lilacinus ocular mycoses in Queensland, Australia | |
Diana Conrad1  Liam Daniel Turner1  | |
[1]Ophthalmology Department, The Royal Brisbane and Women’s Hospital, 10/87 Hampstead Road, Highgate Hill, Brisbane 4101, QLD, Australia | |
关键词: Voriconazole; Paecilomyces; Fungal infection; | |
Others : 1232871 DOI : 10.1186/s13104-015-1591-0 |
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received in 2014-12-18, accepted in 2015-10-14, 发布年份 2015 | |
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【 摘 要 】
Background
The purpose of this study was to report: (1) the varying presentation of Paecilomyces ocular infections arising in Queensland; (2) the significance of immunosuppression as a primary determinant of disease; (3) the outcomes of voriconazole use; and (4) the ongoing need for both surgical and medical management of this devastating fungal infection.
Methods
A retrospective case series of 21 culture proven individuals participated in this series and were identified via a review of the pathology reporting system utilized in the Queensland public health system. All culture proven individuals were subjected to a systematic chart review.
Results
The primary risk factor for Paecilomyces lilacinus infection is immunosuppression with 81.25 % of individuals being on some form of immunosuppression (i.e. systemic or topical). Of the cases 71.43 % had an intact epithelial surface at the time of diagnosis, and 76 % had no previous ocular history. The final visual outcomes were nine cases with HM vision or worse, three cases with 6/48–6/60 vision, three cases 6/12–6/24, and six cases with 6/12 vision or better. Despite voriconazole use rates of greater than 80 %, protracted and poor treatment outcomes continue to be commonplace.
Conclusions
Paecilomyces lilacinus is a filamentous fungus that has a predilection for immunosuppressed individuals. Despite in vitro and case reports demonstrating the effectiveness of voriconazole poor outcomes continue to be seen.
【 授权许可】
2015 Turner and Conrad.
【 预 览 】
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20151116083930292.pdf | 944KB | ![]() |
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