Goishi tea consumption inhibits airway hyperresponsiveness in BALB/c mice

BMC Immunology

Narufumi Suganuma³  Hiroyuki Nakamura¹  Mitsuhiko Miyamura²  Nlandu R Ngatu³  Ryoji Hirota³ 

[1] Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Science, Japan;Department of Pharmacy, Kochi Medical School Hospital, Kochi University, Japan;Department of Environmental Medicine, Kochi Medical School, Kochi University, Japan

关键词: Goishi tea;    eosinophil;    airway hyperresponsiveness;    allergen;    adiponectin;   

Others  :  1077991
DOI  :  10.1186/1471-2172-12-45

 received in 2011-02-01, accepted in 2011-08-11,  发布年份 2011

【 摘 要 】

Background

Airway hyperresponsiveness (AHR) is one of the important traits that characterize bronchial asthma. Goishi tea is a post-heating fermented tea that has been reported to have higher free radical scavenging activity. In this study, we evaluated the prophylactic effects of Goishi tea on AHR in BALB/c mice.

Results

The number of inflammatory cells in BAL fluid was considerably reduced in Goishi tea/Der f and Gallic acid/Der f groups as compared with Tap water/Der f group. Regarding inflammatory cells in BAL, a significant reduction of eosinophils and neutrophils was observed in Goishi tea-treated mice (p < 0.01), as well as in the Gallic acid/Der f group (p < 0.05), as compared with Tap water/Der f group. In asthmatic mice (Tap water/Der f group), the intensity of airway resistance increased simultaneously with the increase in acetylcholine concentration in a dose-dependant way. AHR was significantly inhibited in Goishi tea/Der f and Gallic acid/Der f (p < 0.01) groups as compared with the Tap water/Der f group. Regarding serum specific-IgG₁, significantly lower levels of this antibody were observed in Goishi tea/Der f and Gallic acid/Der f groups as compared with the Tap water/Der f group (p < 0.05). In addition, adiponectin level was significantly higher in the Goishi tea group as compared with the Tap water treated mice (p < 0.01).

Conclusions

The results suggest that Goishi tea consumption exerted an inhibitory effect on eosinophilic and neutrophilic infiltration in the lung, attenuated the increase in airway resistance and increased the production of adiponectin; thus reducing Der f induced allergic inflammatory process in mice.

【 授权许可】

   
2011 Hirota et al; licensee BioMed Central Ltd.

【 图 表 】

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