Association and predictive value analysis for metabolic syndrome on systolic and diastolic heart failure in high-risk patients

BMC Cardiovascular Disorders

Keqin Zhang¹  Fangfang Zeng²  Lin Wang¹  Zi-Hui Tang² 

[1] Department of Endocrinology and Metabolism, Shanghai Tongji Hospital, Tongji University School of Medicine, Building 2nd, NO.389 Xincun Road, Shanghai 200063, China;Department of Cardiology, Fudan University Huashan Hospital, Shanghai, China

关键词: association;    High-risk patients;    Systolic heart failure;    Diastolic heart failure;    Metabolic syndrome;   

Others  :  1088448
DOI  :  10.1186/1471-2261-14-124

 received in 2014-02-20, accepted in 2014-09-18,  发布年份 2014

【 摘 要 】

Background

The purpose of this study was, in high-risk patients, to simultaneously estimate the effect of metabolic syndrome (MetS) on diastolic or systolic heart failure (DHF or SHF), to evaluate MetS predictive value for both outcomes.

Method

We retrospective enrolled 347 high-risk patients who were scheduled to undergo coronary angiography. They were categorized into DHF cases, SHF cases and reference group. The association of MetS with DHF or SHF was assessed by multinomial logistic regression model. The shared contributor to both outcomes was estimated by bivariate association analysis. The predictive performance of MetS severity score was evaluated using the area under the receiver-operating characteristic curve (AUC).

Result

Hypertension (HT) and triglycerides (TG) were detected to independently associate with DHF (P = 0.044 and 0.049, respectively), while HT and fasting plasma glucose (FPG) independently associate with SHF (P = 0.036 and 0.016, respectively). Bivariate association analysis showed that HT as a shared predictor to both outcomes (P = 0.028). MetS severity score significantly associated with DHF or SHF independently (P = 0.004 and 0.043, respectively), and was a shared predictor to both outcomes (P = 0.049), and showed a high value in predicting DHF and SHF (AUC = 0.701 and 0.722, respectively).

Conclusion

Our findings signify that MetS is an independently shared predictor of DHF and SHF, and HT is also independently associated with both outcomes in high-risk patients. Prevalence of DHF or SHF trends to increase with increasing MetS severity showing high predictive value for both outcomes.

【 授权许可】

   
2014 Tang et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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