Investigating mosquito net durability for malaria control in Tanzania - attrition, bioefficacy, chemistry, degradation and insecticide resistance (ABCDR): study protocol

BMC Public Health

Sarah J Moore⁵  William Kisinza³  Karen Kramer⁴  Renata Mandike⁴  Jason D Moore¹  John Bradley⁶  Zawadi D Mageni¹  Dennis J Massue³  Hans J Overgaard²  Lena M Lorenz⁶ 

[1] Ifakara Health Institute, P.O. Box 74, Bagamoyo, Tanzania;Department of Entomology, Kasetsart University, Bangkok, Thailand;National Institute for Medical Research, Amani Research Centre, P.O. Box 81, Muheza, Tanzania;National Malaria Control Program, Ministry of Health and Social Welfare, Dar es Salaam, Tanzania;University of Basel, Petersplatz 1, Basel 4003, Switzerland;London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, U.K

关键词: Insecticide resistance;    Semi-field;    Anopheles;    Malaria control;    Biological efficacy;    Hole index;    Mosquito net;    Durability;    LLINs;    Long-lasting insecticidal nets;   

Others  :  1092429
DOI  :  10.1186/1471-2458-14-1266

 received in 2014-12-03, accepted in 2014-12-09,  发布年份 2014

【 摘 要 】

Background

Long-Lasting Insecticidal Nets (LLINs) are one of the major malaria vector control tools, with most countries adopting free or subsidised universal coverage campaigns of populations at-risk from malaria. It is essential to understand LLIN durability so that public health policy makers can select the most cost effective nets that last for the longest time, and estimate the optimal timing of repeated distribution campaigns. However, there is limited knowledge from few countries of the durability of LLINs under user conditions.

Methods/Design

This study investigates LLIN durability in eight districts of Tanzania, selected for their demographic, geographic and ecological representativeness of the country as a whole. We use a two-stage approach: First, LLINs from recent national net campaigns will be evaluated retrospectively in 3,420 households. Those households will receive one of three leading LLIN products at random (Olyset^®, PermaNet^®2.0 or Netprotect^®) and will be followed up for three years in a prospective study to compare their performance under user conditions. LLIN durability will be evaluated by measuring Attrition (the rate at which nets are discarded by households), Bioefficacy (the insecticidal efficacy of the nets measured by knock-down and mortality of mosquitoes), Chemical content (g/kg of insecticide available in net fibres) and physical Degradation (size and location of holes). In addition, we will extend the current national mosquito insecticide Resistance monitoring program to additional districts and use these data sets to provide GIS maps for use in health surveillance and decision making by the National Malaria Control Program (NMCP).

Discussion

The data will be of importance to policy makers and vector control specialists both in Tanzania and the SSA region to inform best practice for the maintenance of high and cost-effective coverage and to maximise current health gains in malaria control.

【 授权许可】

   
2014 Lorenz et al.; licensee BioMed Central.

【 图 表 】

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