Genetic similarities between tobacco use disorder and related comorbidities: an exploratory study

BMC Medical Genetics

Sander Ouburg¹  Angela Brand³  Herman Van Oyen²  Servaas A Morré¹  Sylviane de Viron³ 

[1] Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands;Operational Direction Public Health and Surveillance, Scientific Institute of Public Health, J. Wytsmanstraat 14, 1050, Brussels, Belgium;Institute for Public Health Genomics (IPHG), Department of Genetics and Cell Biology, Research Institute GROW (School for Oncology & Developmental Biology), Faculty of Health, Medicine & Life Sciences, Maastricht University, Maastricht, The Netherlands

关键词: Tobacco smoking;    Tobacco use disorder;    Public Health Genomics;    Psychiatric disorders;    Network;    Genetics;    Comorbidity;    Cardiovascular disorders;   

Others  :  1091073
DOI  :  10.1186/1471-2350-15-85

 received in 2013-06-18, accepted in 2014-06-25,  发布年份 2014

【 摘 要 】

Background

Tobacco use disorder (TUD), defined as the use of tobacco to the detriment of a person’s health or social functioning, is associated with various disorders. We hypothesized that mutual variation in genes may partly explain this link. The aims of this study were to make a non-exhaustive inventory of the disorders using (partially) the same genetic pathways as TUD, and to describe the genetic similarities between TUD and the selected disorders.

Methods

We developed a 3 stage approach: (i) selection of genes influencing TUD using Gene2Mesh and Ingenuity Pathway Analysis (IPA), (ii) selection of disorders associated with the selected genes using IPA and (iii) genetic similarities between disorders associated with TUD using Jaccard distance and cluster analyses.

Results

Fourteen disorders and thirty-two genes met our inclusion criteria. The Jaccard distance between pairs of disorders ranged from 0.00 (e.g. oesophageal cancer and malignant hypertension) to 0.45 (e.g. bladder cancer and addiction). A lower number in the Jaccard distance indicates a higher similarity between the two disorders. Two main clusters of genetically similar disorders were observed, one including coexisting disorders (e.g. addiction and alcoholism) and the other one with the side-effects of smoking (e.g. gastric cancer and malignant hypertension).

Conclusions

This exploratory study partly explains the potential genetic components linking TUD to other disorders. Two principle clusters of disorders were observed (i) coexisting disorders of TUD and (ii) side-effects of TUD disorders. A further deepening of this observation in a real life study should allow strengthening this hypothesis.

【 授权许可】

   
2014 de Viron et al.; licensee BioMed Central Ltd.

【 图 表 】

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