Post-infectious bronchiolitis obliterans in children: a review of 42 cases

BMC Pediatrics

Huan-Ji Cheng²  Hang Cheng²  Hong-Mei Qiao²  Li Liu²  Ya-Nan Li¹ 

[1] Institute of Pediatrics, The First Hospital of Jilin University, Changchun 130021, PR China;Department of Pediatrics, The First Hospital of Jilin University, Changchun 130021, PR China

关键词: Pulmonary function testing;    Post-infectious bronchiolitis obliterans (PIBO);    HRCT;    Children;   

Others  :  1121298
DOI  :  10.1186/1471-2431-14-238

 received in 2014-08-29, accepted in 2014-09-17,  发布年份 2014

【 摘 要 】

Background

This study aimed to describe the clinical characteristics, radiological features and outcomes of 42 children with post-infectious bronchiolitis obliterans (PIBO).

Methods

Forty-two children diagnosed with PIBO were prospectively studied at the First Hospital of Jilin University in northern China between January, 2008 and January, 2013. Their clinical characteristics, lung high resolution computed tomography (HRCT) findings and pulmonary function tests were reported.

Results

In children with PIBO, adenovirus was the most common etiologic agent (21/42), followed by Mycoplasma pneumoniae (M. pneumoniae). All of the patients presented with repeated wheezing and tachypnea. In addition, 22 patients required intensive management, while six patients required home oxygen therapy. HRCT findings were consistent with the PIBO diagnosis in all of the patients. Pulmonary function testing was useful in evaluating therapeutic responses. Systemic steroids combined with azithromycin were effective for PIBO treatment.

Conclusions

Severe adenovirus bronchiolitis and M. pneumoniae infections have a higher risk of development for PIBO. HRCT and pulmonary function testing are useful in the diagnosis of PIBO. The degree of airway obstruction did not differ significantly between adenovirus and M. pneumoniae. A combination of steroids and azithromycin offers some benefit in treating these patients.

【 授权许可】

   
2014 Li et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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