BMC Nephrology | |
Hepatocyte growth factor signalizes peritoneal membrane failure in peritoneal dialysis | |
Anabela Rodrigues2  António Cabrita3  Maria J Carvalho3  Olívia Santos3  José C Oliveira4  Ana Paula Bernardo1  | |
[1] Largo Prof. Abel Salazar, 4099-001 Porto, Portugal;UMIB/ICBAS/UP, Oporto, Portugal;Nephrology Department, St. António Hospital - Oporto Hospital Center, Oporto, Portugal;Clinical Pathology, St. António Hospital - Oporto Hospital Center, Oporto, Portugal | |
关键词: Water transport; Ultrafiltration failure; Peritoneal membrane; Hepatocyte growth factor; | |
Others : 1082530 DOI : 10.1186/1471-2369-15-201 |
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received in 2014-06-05, accepted in 2014-12-11, 发布年份 2014 | |
【 摘 要 】
Background
Hepatocyte growth factor (HGF) counteracts peritoneal fibrosis in animal models and in-vitro studies, but no study explored effluent HGF in peritoneal dialysis (PD) patients with ultrafiltration failure (UFF). Our aim was to assess the relationship between effluent HGF with UF profile, free water transport (FWT) and small-solute transport.
Methods
We performed 4-hour, 3.86% PET with additional UF measurement at 60 minutes in 68 PD patients. MTACcreatinine, FWT, small-pore ultrafiltration, and effluent HGF were quantified.
Results
Effluent HGF negatively correlated with UF (r = −0.80, p = 0.009) and FWT (r = −0.69, p = 0.04). Patients with UFF had higher dialysate HGF (103 pg/mL vs 77 pg/mL, p = 0.018) and, although not statistically significant, those with FWT compromise had also higher dialysate HGF compared with subgroup of UFF without FWT compromise (104 pg/mL vs 88 pg/mL, p = 0.08). FWT ≤ 45% without clinical UFF was documented in some patients who also had increased effluent HGF.
Conclusions
Dialysate HGF concentration is significantly higher among patients with UFF, specially, if FWT is impaired, being a sign of peritoneal membrane deterioration.
【 授权许可】
2014 Bernardo et al.; licensee BioMed Central.
【 预 览 】
Files | Size | Format | View |
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20141224171254349.pdf | 463KB | download | |
Figure 2. | 31KB | Image | download |
Figure 1. | 13KB | Image | download |
【 图 表 】
Figure 1.
Figure 2.
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