High-sensitive Troponin T increase after exercise in patients with pulmonary arterial hypertension

BMC Pulmonary Medicine

F Joachim Meyer¹  Hugo A Katus²  Evangelos Giannitsis²  Celine S Weiss²  Thomas Zelniker²  David Rohde²  Mirko Völkers² 

[1] Department of Respiratory Medicine, Gastroenterology and Internistic Intensive Care, Munich Municipal Hospital at Harlaching, Munich, Germany;Department of Cardiology, Angiology and Respiratory Medicine, University Medical Center, Heidelberg, D-69120, Germany

关键词: Cardiopulmonary exercise testing;    Pulmonary arterial hypertension;    High-sensitive Troponin T;   

Others  :  1109899
DOI  :  10.1186/1471-2466-13-28

 received in 2012-09-25, accepted in 2013-04-23,  发布年份 2013

【 摘 要 】

Background

The current study aimed to investigate the release of myocardial high-sensitive Troponin T (hsTnT) in patients with pulmonary arterial hypertension (PAH) in response to maximal physical exercise.

Methods

In 24 patients with PAH, symptom-limited cardiopulmonary exercise testing was performed. hsTnT was measured by the novel hsTnT assay with a lower limit of detection of 2 ng/L and a total imprecision of less than 10% at the 99^th percentile value. hsTnT was related to NT-proBNP, WHO functional class and right ventricular (RV) function. Serial measurement was performed before and 30 min, 180 min, and 300 min after exercise. Healthy volunteers served as a control group.

Results

In 21 PAH patients, hsTnT levels were detectable before exercise with a close correlation between hsTnT and NT-proBNP. hsTnT was detectable in all PAH patients after exercise and significantly increased from 7.5 ng/L at baseline to 14.62 ng/L after 300 min, whereas levels of NT-proBNP remained constant with time.

Conclusions

Using the novel hsTnT assay, the current study provides first evidence that hsTnT levels increase in PAH patients after maximal physical exercise, while levels of other biomarkers remain constant after exercise testing. This might provide new insights into pathophysiology and individual risk assessment in patients with PAH.

【 授权许可】

   
2013 Völkers et al.; licensee BioMed Central Ltd.

【 图 表 】

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