Disability-adjusted-life-years losses in postmenopausal women with osteoporosis: a burden of illness study

BMC Public Health

Javier Rejas⁴  José Luis Neyro³  Santiago Palacios¹  Nuria Pérez-Álvarez⁵  Lisette Kaskens⁵  Josep Darbಠ

[1] Instituto Palacios de Salud y Medicina de la Mujer, Calle Antonio Acuña, 9, Madrid, 28009, Spain;Department of Economics, Universitat de Barcelona, Diagonal 690, Barcelona, 08034, Spain;Department of Obstetrics and Gynaecology, Hospital Universitario Cruces, Gran Vía 81-4, Bilbao, 48011, Spain;Health Economics and Outcomes Research Department, Pfizer, S.L.U., Avda. Europa 20B. Parque Empresarial la Moraleja, Alcobendas, 28108, Madrid, Spain;BCN Health Economics & Outcomes Research S.L., Travessera de Gracia 62, 5-6, Barcelona, 08006, Spain

关键词: Osteoporotic risk fracture factors;    Drug-based therapy;    Disability weights;    Menopause;    Osteoporosis;    Burden of illness;    Disability-adjusted life year;   

Others  :  1164182
DOI  :  10.1186/s12889-015-1684-7

 received in 2013-10-25, accepted in 2015-03-26,  发布年份 2015

【 摘 要 】

Background

To estimate the disability-adjusted life years (DALY) in a nationwide representative sample of postmenopausal women with osteoporosis. The effects of drug-based therapy and risk factors for osteoporotic bone fractures on DALY losses were also explored.

Methods

DALY were estimated based on participant’s clinical characteristics and Health-Related Quality-of-Life (HRQoL) data obtained from a cross-sectional, epidemiological one-visit study (the GINERISK study). The study enrolled postmenopausal women (at least 12-months after their last menstrual period) with osteoporosis, above 18-years old, who attended Spanish outpatient Gynaecology clinics. HRQoL was assessed using the generic SF-12v2 questionnaire, which was used to derive disutility values. Mortality rates were extracted from the Spanish national statistics database. Factors explored to be associated with DALY losses were examined using ANOVA, ANCOVA and MANCOVA models.

Results

DALY could be computed in 2,782 (67%) out of 4,157 postmenopausal women, with a mean (95% CI) age of 61.0 (60.7-61.2) years. Overall individual undiscounted DALY per woman were 6.1 (5.9-6.2), resulting to be significantly higher in women with severe osteoporosis with prior bone fracture; 7.8 (7.2-8.4) compared to osteoporotic women [5.8 (5.6-6.0)] or postmenopausal women with a BMD > −2.5 T-score that received a drug-based therapy [6.2 (5.8-6.5)]; F = 27.0 (P < 0.01). Models explaining the variation in the levels of health based on the use of a selective estrogen receptor modulator (SERM) or possession of risk factors for osteoporotic BF were found (P < 0.05).

Conclusions

DALY losses were considerable amongst postmenopausal women with osteoporosis. Not having a prior bone fracture, being older, using a SERM and having less osteoporotic risk factors were all linked to less DALY losses.

【 授权许可】

   
2015 Darba et al.; licensee BioMed Central.

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