Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans

BMC Complementary and Alternative Medicine

Seongwon Cha²  Jong Yeol Kim¹  Ah Yeon Park²  Hyunjoo Yu²  Sun-Ku Chung² 

[1] Medical Engineering R&D Group, Medical Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea;KM Health Technology Research Group, Medical Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea

关键词: Constitutional type;    LPL;    LIPG;    APOE-APOC1-APOC4;    APOA5-APOA4-APOC3-APOA1;    ANGPTL3;    Dyslipidemia;    Cholesterol;    Lipid-associated variants;   

Others  :  1087426
DOI  :  10.1186/1472-6882-14-230

 received in 2013-07-25, accepted in 2014-07-02,  发布年份 2014

【 摘 要 】

Background

Abnormal lipid concentrations are risk factors for atherosclerosis and cardiovascular disease. The pathological susceptibility to cardiovascular disease risks such as metabolic syndrome, diabetes mellitus, hypertension, insulin resistance, and so on differs between Sasang constitutional types.

Methods

We used multiple regression analyses to study the association between lipid-related traits and genetic variants from several genome-wide association studies according to Sasang constitutional types, considering that the Tae-Eum (TE) has predominant cardiovascular risk.

Results

By analyzing 26 variants of 20 loci in two Korean populations (8,597 subjects), we found that 12 and 5 variants, respectively, were replicably associated with lipid levels and dyslipidemia risk. By analyzing TE and non-TE type (each 2,664 subjects) populations classified on the basis of Sasang constitutional medicine, we found that the minor allele effects of three variants enriched in TE type had a harmful influence on lipid risk (near apolipoprotein A-V (APOA5)-APOA4-APOC3-APOA1 on increased triglyceride: p = 8.90 × 10^-11, in APOE-APOC1-APOC4 on increased low-density lipoprotein cholesterol: p = 1.63 × 10^-5, and near endothelial lipase gene on decreased high-density lipoprotein cholesterol: p = 4.28 × 10^-3), whereas those of three variants (near angiopoietin-like 3 gene, APOA5-APOA4-APOC3-APOA1, and near lipoprotein lipase gene on triglyceride and high-density lipoprotein cholesterol) associated in non-TE type had neutral influences because of a compensating effect.

Conclusions

These results implied that the minor allele effects of lipid-associated variants may predispose TE type subjects to high cardiovascular disease risk because of their genetic susceptibility to lipid-related disorders.

【 授权许可】

   
2014 Chung et al.; licensee BioMed Central Ltd.

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