Morning blood pressure surge and target organ damage in newly diagnosed type 2 diabetic patients: a cross sectional study

BMC Endocrine Disorders

Per L. Poulsen¹  Troels K. Hansen¹  Klavs W. Hansen²  Søren T. Knudsen¹  Jens S. Christiansen¹  Simon Cichosz¹  Pernille Høyem¹  Esben Laugesen¹  Johanne M. Lyhne¹ 

[1]Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Nørrebrogade 44, Aarhus C, DK-8000, Denmark

[2]Medical department, Diagnostic Center, Regional Hospital Silkeborg, Silkeborg, Denmark

关键词: Vascular target organ damage;    Type 2 diabetes;    Ambulatory blood pressure monitoring;    Systolic night-day ratio;    Morning blood pressure surge;   

Others  :  1234623
DOI  :  10.1186/s12902-015-0068-4

 received in 2015-08-19, accepted in 2015-11-13,  发布年份 2015

【 摘 要 】

Background

Type 2 diabetic patients display significantly higher incidence of cardiovascular (CV) events including stroke compared to non-diabetics. Morning blood pressure surge (MBPS) and blunted systolic night-day (SND) ratio have been associated with CV events in hypertensive patients. No studies have evaluated MBPS in newly diagnosed diabetic patients or studied the association with vascular target organ damage at this early time point of the diabetes disease.

Methods

Ambulatory blood pressure monitoring was performed in 100 patients with newly diagnosed type 2 diabetes and 100 age and sex matched controls. MBPS and SND-ratio were calculated. Markers of early vascular target organ damage included pulse wave velocity (PWV), white matter lesions (WML) on brain MRI, and urine albumin/creatinine ratio (UAE).

Results

No significant differences in MBPS were found between diabetic patients and controls. Neither MBPS or SND-ratio were associated with PWV, UAE or WML in the diabetic group independently of age, gender and 24-h systolic blood pressure. 40.2 % of diabetic patients and 25.8 % of controls were classified as non-dippers (p = 0.03).

Conclusion

MBPS and SND-ratio are not associated with subclinical markers of vascular target organ damage in our study sample of newly diagnosed type 2 diabetic patients.

【 授权许可】

   
2015 Lyhne et al.

【 图 表 】

Fig. 1.

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