An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro

BMC Infectious Diseases

Kathryn J Else¹  David B Sattelle²  Timothy Burgis¹  Frederick A Partridge²  Amanda L Gallagher¹  Thomas Hopwood¹  Rebecca JM Hurst¹ 

[1] Faculty of Life Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK;Wolfson Institute for Biomedical Research, Division of Medicine, University College London, Cruciform Building, Gower Street, London WC1E 6BT, UK

关键词: Anthelmintic;    Viability;    Nematode;    Trichuris muris;    HX531;    RXR;   

Others  :  1125500
DOI  :  10.1186/1471-2334-14-520

 received in 2014-02-21, accepted in 2014-09-17,  发布年份 2014

【 摘 要 】

Background

Trichuriasis is a parasitic disease caused by the human whipworm, Trichuris trichiura. It affects millions worldwide, particularly in the tropics. This nematode parasite burrows into the colonic epithelium resulting in inflammation and morbidity, especially in children. Current treatment relies mainly on general anthelmintics such as mebendazole but resistance to these drugs is increasingly problematic. Therefore, new treatments are urgently required.

Methods

The prospect of using the retinoid X receptor (RXR) antagonist HX531 as a novel anthelmintic was investigated by carrying out multiple viability assays with the mouse whipworm Trichuris muris.

Results

HX531 reduced both the motility and viability of T. muris at its L3, L4 and adult stages. Further, bioinformatic analyses show that the T. muris genome possesses an RXR-like receptor, a possible target for HX531.

Conclusions

The study suggested that Trichuris-specific RXR antagonists may be a source of much-needed novel anthelmintic candidates for the treatment of trichuriasis. The identification of an RXR-like sequence in the T. muris genome also paves the way for further research based on this new anthelmintic lead compound.

【 授权许可】

   
2014 Hurst et al.; licensee BioMed Central Ltd.

【 图 表 】

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