Cutaneous metastasis of prostate carcinoma treated with radiotherapy: a case presentation

BMC Research Notes

Paul De Souza²  Najmun Nahar¹  Melvin Chin³  Gabriel Mak³ 

[1] Crown Princess Mary Cancer Centre, Westmead Hospital, Sydney, Australia;Ingham Institute, School of Medicine, University of Western Sydney, Liverpool Hospital, Sydney, Australia;Prince of Wales Hospital; Prince of Wales Clinical School, University of New South Wales, Sydney, Australia

关键词: Radiotherapy;    Cutaneous metastasis;    Metastasis;    Prostate cancer;   

Others  :  1136439
DOI  :  10.1186/1756-0500-7-505

 received in 2014-01-03, accepted in 2014-08-01,  发布年份 2014

【 摘 要 】

Background

Prostate cancer is a commonly diagnosed and treated malignancy, although it rarely presents with cutaneous metastases. In this case presentation, we describe the diagnosis and treatment with radiotherapy of a patient who presented with cutaneous metastases on his chest wall secondary to prostate cancer.

Case presentation

In 2006, a 73-year-old Caucasian gentleman with metastatic castration resistant prostate cancer treated with mitoxantrone and prednisolone presented with cutaneous nodules on his chest wall. A punch biopsy diagnosed cutaneous metastases, with histological confirmation with positive staining for cytokeratin, PSA (prostate specific antigen) and PAP (prostatic acid phosphatise). Systemic treatment was ceased due to progressive disease; radiotherapy was used to treat these nodules with a durable clinical response. The patient died five months after initial diagnosis of cutaneous metastases.

Conclusions

In this report, a rare metastatic manifestation of a common malignancy is presented. Whilst dermal metastases carries a poor prognosis from reported literature, this is the first report of radiotherapy providing a durable clinical response with relief from bleeding and pain.

【 授权许可】

   
2014 Mak et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

Figure 4.

【 参考文献 】

• [1]Australian Institute of Health and Welfare & Australasian Association of Cancer Registries: Cancer in Australia: an overview 2012. Canberra: AIHW; 2012. [Cancer series no. 74. Cat. no. CAN 70]
• [2]Krathen RA, Orengo IF, Rosen T: Cutaneous metastasis: a meta-analysis of data. South Med J 2003, 96(2):164-167.
• [3]Mueller TJ, Wu H, Greenberg RE, Hudes G, Topham N, Lessin SR, Uzzo RG: Cutaneous metastases from genitourinary malignancies. Urology 2004, 63(6):1021-1026.
• [4]Pique Duran E, Paradela A, Farina MC, Escalonilla P, Soriano ML, Olivares M, Sarasa JL, Martin L, Requena L: Cutaneous metastases from prostatic carcinoma. J Surg Oncol 1996, 62(2):144-147.
• [5]Katske FA, Waisman J, Lupu AN: Cutaneous and subcutaneous metastases from carcinoma of prostate. Urology 1982, 19(4):373-376.
• [6]Bailey C, Broadbent A: Cutaneous metastases of prostate cancer. J Palliat Med 2007, 10(4):980-982.
• [7]Abrol N, Seth A, Chattergee P: Cutaneous metastasis of prostate carcinoma to neck and upper chest. Indian J Pathol Microbiol 2011, 54(2):394-395.
• [8]Rattanasirivilai A, Kurban A, Lenzy Y, Yaar R: Cutaneous metastasis of prostatic adenocarcinoma: a cautionary tale. J Cutan Pathol 2011, 38(6):521-524.
• [9]Wang SQ, Mecca PS, Myskowski PL, Slovin SF: Scrotal and penile papules and plaques as the initial manifestation of a cutaneous metastasis of adenocarcinoma of the prostate: case report and review of the literature. J Cutan Pathol 2008, 35(7):681-684.
• [10]Reddy S, Bang R, Contreras M: Telangiectatic cutaneous metastasis from carcinoma of the prostate. Br J Dermatol 2007, 156(3):598-600.
• [11]Petcu E, Gonzalez-Serva A, Wright R, Slevin M, Brinzaniuc K: Prostate carcinoma metastatic to the skin as an extrammamary Paget’s disease. Diagn Pathol 2012, 7(1):106.
• [12]Varma M, Jasani B: Diagnostic utility of immunohistochemistry in morphologically difficult prostate cancer: review of current literature. Histopathology 2005, 47(1):1-16.