Quality of life and acquired organ damage are intimately related to activity limitations in patients with systemic lupus erythematosus

BMC Musculoskeletal Disorders

Christopher Sjöwall¹  Jonas Wetterö¹  Örjan Dahlström²  Mathilda Björk³ 

[1] Rheumatology/AIR, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden;Swedish Institute for Disability Research, Department of Behavioural Sciences and Learning, Linköping University, Linköping, Sweden;Department of Rehabilitation, School of Health Sciences, Jönköping University, Jönköping, Sweden

关键词: Disease phenotype;    Activity limitation;    Quality of life;    Disability;    Organ damage;    Disease burden;    Systemic lupus erythematosus;   

Others  :  1227696
DOI  :  10.1186/s12891-015-0621-3

 received in 2014-08-29, accepted in 2015-07-03,  发布年份 2015

【 摘 要 】

Background

Systemic lupus erythematosus (SLE) is an autoimmune multi-organ disease, characterized by episodes of disease flares and remissions over time, which may restrain affected patients’ ability to perform daily activities. The purpose of the present study was to characterize variation in activity limitations among well-defined SLE patients, and to describe disease phenotypes, acquired organ damage and their relations to activity limitation and self-reported health, respectively.

Methods

The disease phenotypes were organized into 4 different clinical groups and logistic regression analyses were used to identify how an elevated health assessment questionnaire (HAQ) score was related to disease variables such as phenotypes, disease activity and damage accrual. Correlation and multiple linear regression analyses were used to examine the association between each group of variables – background variables, disease variables and self-reported measurements – and the degree of elevated HAQ.

Results

We found a higher proportion of activity limitation in patients with skin and joint involvement compared to others. The presence of activity limitation, as detected by the HAQ instrument, was significantly associated with quality of life (EuroQol–5D) and accrual of organ damage using the Systemic Lupus International Collaborative Clinics/ACR damage index.

Conclusions

The findings highlight the differing requirements of the multi-professional rehabilitation interventions for the various SLE phenotypes in order to optimize the clinical care of the patients.

【 授权许可】

   
2015 Björk et al.

【 图 表 】

Fig. 1.

Fig. 2.

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