Association analysis between HOXD9 genes and the development of developmental dysplasia of the hip in Chinese female Han population

BMC Musculoskeletal Disorders

Xu Ma⁴  Binbin Wang³  Shilian Kan¹  Jian Jia¹  Zhi Cheng³  Longfei Cheng³  Jianmin Wang²  Peisu Suo³  Jing Wang³  Lixi Zhao³  Wei Tian¹ 

[1] Department of Orthopaedic Trauma, Tianjin hospital, Tianjin, China;Huabei oil field hospital, Hebei, China;Center for Genetics, National Research Institute for Family Planning, 12, Dahuisi Road, Haidian, Beijing, 100081, China;World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China

关键词: Association analysis;    Tag SNP;    HOXD9;    Developmental dysplasia of the hip (DDH);   

Others  :  1150046
DOI  :  10.1186/1471-2474-13-59

 received in 2011-12-10, accepted in 2012-04-20,  发布年份 2012

【 摘 要 】

Background

Developmental dysplasia of the hip (DDH) is a congenital or acquired deformation or misalignment of the hip joint which affects mainly females. We hypothesized that HOXD9 gene could be regulated in acetabular size or shape and related in DDH developing.

Methods

Two hundred and nine Chinese Han female DDH patients and 173 ethnic, age matched healthy female controls were genotyped for HOXD9 two tag SNPs using sequenom method.

Results

One of the two tag SNPs, rs711822, was not shown significantly differences in genotypic or allelic distribution between case and control group. Comparing the genotypic distribution of rs711819, there was significant differences between DDH patients group and control group (χ2 = 7.54, df =2, P =0.023), and the association to DDH developing reached significance (P =0.045, OR =1.79, 95 % CI: 1.01-3.17 by dominant mode).

Conclusion

In conclusion, the association between one tag SNP of HOXD9 gene and the development of DDH reach significant in our study population, this result indicate the positive correlation between HOXD9 gene and DDH developing. Further study in larger sample size and different population as well as functional studies will help to understand the pathogenesis of DDH.

【 授权许可】

   
2012 Tian et al.; licensee BioMed Central Ltd.

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