A randomized, controlled cross-over trial of dermally-applied lavender (Lavandula angustifolia) oil as a treatment of agitated behaviour in dementia

BMC Complementary and Alternative Medicine

Eva S van der Ploeg¹  John Taffe¹  Barbara Eppingstall¹  Daniel W O’Connor¹ 

[1] School of Psychology and Psychiatry, Monash University, Kingston Centre, Warrigal Road, Cheltenham, Victoria 3192, Australia

关键词: Randomised controlled trial;    Mood;    Behaviour;    Dementia;    Lavender;   

Others  :  1220525
DOI  :  10.1186/1472-6882-13-315

 received in 2012-11-16, accepted in 2013-11-01,  发布年份 2013

【 摘 要 】

Background

Lavender essential oil shows evidence of sedative properties in neurophysiological and animal studies but clinical trials of its effectiveness as a treatment of agitation in people with dementia have shown mixed results. Study methods have varied widely, however, making comparisons hazardous. To help remedy previous methodological shortcomings, we delivered high grade lavender oil in specified amounts to nursing home residents whose agitated behaviours were recorded objectively.

Methods

64 nursing home residents with frequent physically agitated behaviours were entered into a randomized, single-blind cross-over trial of dermally-applied, neurophysiologically active, high purity 30% lavender oil versus an inactive control oil. A blinded observer counted the presence or absence of target behaviours and rated participants’ predominant affect during each minute for 30 minutes prior to exposure and for 60 minutes afterwards.

Results

Lavender oil did not prove superior to the control oil in reducing the frequency of physically agitated behaviours or in improving participants’ affect.

Conclusions

Studies of essential oils are constrained by their variable formulations and uncertain pharmacokinetics and so optimal dosing and delivery regimens remain speculative. Notwithstanding this, topically delivered, high strength, pure lavender oil had no discernible effect on affect and behaviour in a well-defined clinical sample.

Trial registration

Australian and New Zealand Clinical Trials Registry (ACTRN 12609000569202)

【 授权许可】

   
2013 O’Connor et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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