Serum levels of N–terminal proB–type natriuretic peptide in mechanically ventilated critically ill patients – relation to tidal volume size and development of acute respiratory distress syndrome

BMC Pulmonary Medicine

Marcus J Schultz¹  Jan P van Straalen³  Jan M Binnekade²  Anita M de Boer¹  Jacqueline Schaefers¹  Annick ANM Royakkers⁵  Rogier M Determann⁴ 

[1] Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands;Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands;Department of Anesthesiology, Tergooi Hospitals, Blaricum, The Netherlands;Department of Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands;Laboratory of Clinical Chemistry (LAKC), Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

关键词: NT–proBNP;    Ventilator–associated lung injury;    Tidal volume;    Acute lung injury;    Mechanical ventilation;   

Others  :  1109809
DOI  :  10.1186/1471-2466-13-42

 received in 2012-12-30, accepted in 2013-07-05,  发布年份 2013

【 摘 要 】

Background

Serum levels of N–terminal proB–type natriuretic peptide (NT–proBNP) are elevated in patients acute respiratory distress syndrome (ARDS). Recent studies showed a lower incidence of acute cor pulmonale in ARDS patients ventilated with lower tidal volumes. Consequently, serum levels of NT–proBNP may be lower in these patients.

We investigated the relation between serum levels of NT–proBNP and tidal volumes in critically ill patients without ARDS at the onset of mechanical ventilation.

Methods

Secondary analysis of a randomized controlled trial of lower versus conventional tidal volumes in patients without ARDS. NT–pro BNP were measured in stored serum samples. Serial serum levels of NT–pro BNP were analyzed controlling for acute kidney injury, cumulative fluid balance and presence of brain injury. The primary outcome was the effect of tidal volume size on serum levels of NT–proBNP. Secondary outcome was the association with development of ARDS.

Results

Samples from 150 patients were analyzed. No relation was found between serum levels of NT–pro BNP and tidal volume size. However, NT-proBNP levels were increasing in patients who developed ARDS. In addition, higher levels were observed in patients with acute kidney injury, and in patients with a more positive cumulative fluid balance.

Conclusion

Serum levels of NT–proBNP are independent of tidal volume size, but are increasing in patients who develop ARDS.

【 授权许可】

   
2013 Determann et al.; licensee BioMed Central Ltd.

【 图 表 】

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