The Association of vitamin D status and fasting glucose according to body fat mass in young healthy Thais

BMC Endocrine Disorders

Boonsong Ongphiphadhanakul¹  Piyamitr Sritara¹  Suwannee Chanprasertyothin¹  La-or Chailurkit¹  Hataikarn Nimitphong¹ 

[1] Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama 6 Rd., Rajthevi, Bangkok 10400, Thailand

关键词: Adiposity;    Total body fat mass;    Fasting plasma glucose;    25-hydroxyvitamin D;   

Others  :  1085434
DOI  :  10.1186/1472-6823-13-60

 received in 2013-08-28, accepted in 2013-12-20,  发布年份 2013

【 摘 要 】

Background

Existing inconclusive data on the relationship between vitamin D status and human glucose homeostasis suggests that other factors, such as adiposity, might influence this relationship. The present study aimed to investigate the association between 25-hydroxyvitamin D [25(OH)D] and fasting plasma glucose (FPG) in the context of different amounts of total body fat in a healthy community-based population in Bangkok, Thailand.

Methods

This cross-sectional study was a part of health survey of employees of the Electricity Generating Authority of Thailand. There were 1,990 healthy subjects (72.8% male) in this study. Total body fat was measured by bioelectrical impedance analysis. Total serum 25(OH)D, 25(OH)D₃ and 25(OH)D₂ were measured by LC-MS/MS.

Results

Age (r = 0.134, p < 0.001) and FPG (r = 0.089, p < 0.001) were positively correlated with 25(OH)D levels, while total body fat mass (r = -0.049, p = 0.03) were negatively correlated with 25(OH)D levels. 25(OH)D levels were higher in males than in females (65.0 ± 0.5 vs. 53.5 ± 0.5 nmol/L, p < 0.001). After controlling for age, gender and total fat mass, FPG was no longer correlated with 25(OH)D. However, when subjects were stratified according to fat-free mass tertiles and controlled for age and gender, there was a positive, although weak association between 25(OH)D levels and FPG (p = 0.01) in the lowest tertile.

Conclusions

We therefore speculate that adiposity might influence the relationship of vitamin D status and FPG.

【 授权许可】

   
2013 Nimitphong et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Adams JS, Hewison M: Update in vitamin D. J Clin Endocrinol Metab 2010, 95(2):471-478.
• [2]Holick MF: Vitamin D: extraskeletal health. Endocrinol Metab Clin North Am 2010, 39(2):381-400. table of contents
• [3]Johnson JA, Grande JP, Roche PC, Kumar R: Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbindin D28k in human and rat pancreas. Am J Physiol 1994, 267(3 Pt 1):E356-E360.
• [4]Kadowaki S, Norman AW: Pancreatic vitamin D-dependent calcium binding protein: biochemical properties and response to vitamin D. Arch Biochem Biophys 1984, 233(1):228-236.
• [5]von Hurst PR, Stonehouse W, Coad J: Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial. Br J Nutr 2010, 103(4):549-555.
• [6]Pittas AG, Harris SS, Stark PC, Dawson-Hughes B: The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care 2007, 30(4):980-986.
• [7]Alvarez JA, Ashraf A: Role of vitamin d in insulin secretion and insulin sensitivity for glucose homeostasis. Int J Endocrinol 2010, 351385.
• [8]Mitri J, Muraru MD, Pittas AG: Vitamin D and type 2 diabetes: a systematic review. Eur J Clin Nutr 2011, 65(9):1005-1015.
• [9]Pittas AG, Nelson J, Mitri J, Hillmann W, Garganta C, Nathan DM, Hu FB, Dawson-Hughes B: Plasma 25-hydroxyvitamin D and progression to diabetes in patients at risk for diabetes: an ancillary analysis in the Diabetes Prevention Program. Diabetes Care 2012, 35(3):565-573.
• [10]Chailurkit LO, Aekplakorn W, Ongphiphadhanakul B: The association between vitamin D status and type 2 diabetes in a Thai population, a cross-sectional study. Clin Endocrinol (Oxf) 2012, 77(5):658-664.
• [11]Narvaez CJ, Matthews D, Broun E, Chan M, Welsh J: Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue. Endocrinology 2009, 150(2):651-661.
• [12]Wong KE, Szeto FL, Zhang W, Ye H, Kong J, Zhang Z, Sun XJ, Li YC: Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins. Am J Physiol Endocrinol Metab 2009, 296(4):E820-E828.
• [13]Lenders CM, Feldman HA, Von Scheven E, Merewood A, Sweeney C, Wilson DM, Lee PD, Abrams SH, Gitelman SE, Wertz MS, Klish WJ, Taylor GA, Chen TC, Holick MF, Elizabeth Glaser Pediatric Research Network Obesity Study Group: Relation of body fat indexes to vitamin D status and deficiency among obese adolescents. Am J Clin Nutr 2009, 90(3):459-467.
• [14]Looker AC, Pfeiffer CM, Lacher DA, Schleicher RL, Picciano MF, Yetley EA: Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004. Am J Clin Nutr 2008, 88(6):1519-1527.
• [15]Valina-Toth AL, Lai Z, Yoo W, Abou-Samra A, Gadegbeku CA, Flack JM: Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans. Clin Endocrinol (Oxf) 2010, 72(5):595-603.
• [16]Vathesatogkit P, Woodward M, Tanomsup S, Hengprasith B, Aekplakorn W, Yamwong S, Sritara P: Long-term effects of socioeconomic status on incident hypertension and progression of blood pressure. J Hypertens 2012, 30(7):1347-1353.
• [17]Vathesatogkit P, Woodward M, Tanomsup S, Ratanachaiwong W, Vanavanan S, Yamwong S, Sritara P: Cohort profile: the electricity generating authority of Thailand study. Int J Epidemiol 2012, 41(2):359-365.
• [18]Institute of Medicine: Dietary reference intakes for calcium and vitamin D. Washington, DC: National Academy of Science; 2011.
• [19]Moy FM, Bulgiba A: High prevalence of vitamin D insufficiency and its association with obesity and metabolic syndrome among Malay adults in Kuala Lumpur, Malaysia. BMC Public Health 2011, 11:735. BioMed Central Full Text
• [20]Choi HS, Kim KA, Lim CY, Rhee SY, Hwang YC, Kim KM, Kim KJ, Rhee Y, Lim SK: Low serum vitamin D is associated with high risk of diabetes in Korean adults. J Nutr 2011, 141(8):1524-1528.
• [21]Lu L, Yu Z, Pan A, Hu FB, Franco OH, Li H, Li X, Yang X, Chen Y, Lin X: Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care 2009, 32(7):1278-1283.
• [22]Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF: Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000, 72(3):690-693.
• [23]Tzotzas T, Papadopoulou FG, Tziomalos K, Karras S, Gastaris K, Perros P, Krassas GE: Rising serum 25-hydroxy-vitamin D levels after weight loss in obese women correlate with improvement in insulin resistance. J Clin Endocrinol Metab 2010, 95(9):4251-4257.
• [24]Chacko SA, Song Y, Manson JE, Van Horn L, Eaton C, Martin LW, McTiernan A, Curb JD, Wylie-Rosett J, Phillips LS, Plodkowski RA, Liu S: Serum 25-hydroxyvitamin D concentrations in relation to cardiometabolic risk factors and metabolic syndrome in postmenopausal women. Am J Clin Nutr 2011, 94(1):209-217.
• [25]Wong KE, Kong J, Zhang W, Szeto FL, Ye H, Deb DK, Brady MJ, Li YC: Targeted expression of human vitamin D receptor in adipocytes decreases energy expenditure and induces obesity in mice. J Biol Chem 2011, 286(39):33804-33810.
• [26]Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR: Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009, 360(15):1509-1517.
• [27]Standards of medical care in diabetes Diabetes Care 2012, 35(Suppl 1):S11-S63.
• [28]McDonald TJ, Ellard S: Maturity onset diabetes of the young: identification and diagnosis. Ann Clin Biochem 2013, 50(Pt 5):403-415.