BMC Nephrology | |
Outpatient red blood cell transfusion payments among patients on chronic dialysis | |
Akhtar Ashfaq3  Shaowei Wan3  Helen V Varker4  Katherine A Cappell4  Zhun Cao4  Brian S Custer2  Xue Song4  Jeffrey L Carson1  David M Spiegel5  J Andrew Lee3  Matthew Gitlin3  | |
[1] UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, USA;Blood Systems Research Institute, San Francisco, CA, USA;Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA, USA;Truven Health Analytics, Cambridge, MA, USA;University of Colorado, Denver, CO, USA | |
关键词: Cost; Payers; Red blood cell transfusions; Dialysis; | |
Others : 1083066 DOI : 10.1186/1471-2369-13-145 |
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received in 2012-03-21, accepted in 2012-10-28, 发布年份 2012 | |
【 摘 要 】
Background
Payments for red blood cell (RBC) transfusions are separate from US Medicare bundled payments for dialysis-related services and medications. Our objective was to examine the economic burden for payers when chronic dialysis patients receive outpatient RBC transfusions.
Methods
Using Truven Health MarketScan® data (1/1/02-10/31/10) in this retrospective micro-costing economic analysis, we analyzed data from chronic dialysis patients who underwent at least 1 outpatient RBC transfusion who had at least 6 months of continuous enrollment prior to initial dialysis claim and at least 30 days post-transfusion follow-up. A conceptual model of transfusion-associated resource use based on current literature was employed to estimate outpatient RBC transfusion payments. Total payments per RBC transfusion episode included screening/monitoring (within 3 days), blood acquisition/administration (within 2 days), and associated complications (within 3 days for acute events; up to 45 days for chronic events).
Results
A total of 3283 patient transfusion episodes were included; 56.4% were men and 40.9% had Medicare supplemental insurance. Mean (standard deviation [SD]) age was 60.9 (15.0) years, and mean Charlson comorbidity index was 4.3 (2.5). During a mean (SD) follow-up of 495 (474) days, patients had a mean of 2.2 (3.8) outpatient RBC transfusion episodes. Mean/median (SD) total payment per RBC transfusion episode was $854/$427 ($2,060) with 72.1% attributable to blood acquisition and administration payments. Complication payments ranged from mean (SD) $213 ($168) for delayed hemolytic transfusion reaction to $19,466 ($15,424) for congestive heart failure.
Conclusions
Payments for outpatient RBC transfusion episodes were driven by blood acquisition and administration payments. While infrequent, transfusion complications increased payments substantially when they occurred.
【 授权许可】
2012 Gitlin et al.; licensee BioMed Central Ltd.
【 预 览 】
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20141224194002635.pdf | 1506KB | download | |
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Figure 1. | 38KB | Image | download |
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【 参考文献 】
- [1]Sargent JA, Acchiardo SR: Iron requirements in hemodialysis. Blood Purif 2004, 22(1):112-123.
- [2]Churchill DN, Taylor DW, Cook RJ, LaPlante P, Barre P, Cartier P, Fay WP, Goldstein MB, Jindal K, Mandin H, et al.: Canadian hemodialysis morbidity study. Am J Kidney Dis 1992, 19(3):214-234.
- [3]Eschbach JW, Adamson JW: Anemia of end-stage renal disease (ESRD). Kidney Int 1985, 28(1):1-5.
- [4]Beauregard P, Blajchman MA: Hemolytic and pseudo-hemolytic transfusion reactions: an overview of the hemolytic transfusion reactions and the clinical conditions that mimic them. Transfus Med Rev 1994, 8(3):184-199.
- [5]Despotis GJ, Zhang L, Lublin DM: Transfusion risks and transfusion-related pro-inflammatory responses. Hematol Oncol Clin North Am 2007, 21(1):147-161.
- [6]Dodd RY, Notari EP, Stramer SL: Current prevalence and incidence of infectious disease markers and estimated window-period risk in the American Red Cross blood donor population. Transfusion (Paris) 2002, 42(8):975-979.
- [7]Eder AF, Chambers LA: Noninfectious complications of blood transfusion. Arch Pathol Lab Med 2007, 131(5):708-718.
- [8]Gilliss BM, Looney MR, Gropper MA: Reducing noninfectious risks of blood transfusion. Anesthesiology 2011, 115(3):635-649.
- [9]Simon GE, Bove JR: The potassium load from blood transfusion. Postgrad Med 1971, 49(6):61-64.
- [10]Vella JP, O’Neill D, Atkins N, Donohoe JF, Walshe JJ: Sensitization to human leukocyte antigen before and after the introduction of erythropoietin. Nephrol Dial Transplant 1998, 13(8):2027-2032.
- [11]The 2009 National Blood Collection and Utilization Survey Report. Washington, DC: US Department of Health and Human Services, Office of the Assistant Secretary for Health; 2011.
- [12]Allain JP, Stramer SL, Carneiro-Proietti AB, Martins ML, da Silva SN L, Ribeiro M, Proietti FA, Reesink HW: Transfusion-transmitted infectious diseases. Biologicals 2009, 37(2):71-77.
- [13]Healthcare Cost and Utilization Project (HCUP): HCUP Nationwide Inpatient Sample (NIS). Rockville, MD: Agency for Healthcare Research and Quality; 2007–2009.
- [14]Kumar A: Perioperative management of anemia: limits of blood transfusion and alternatives to it. Cleve Clin J Med 2009, 76(Suppl 4):S112-S118.
- [15]Goodnough LT, Strasburg D, Riddell J, Verbrugge D, Wish J: Has recombinant human erythropoietin therapy minimized red-cell transfusions in hemodialysis patients? Clin Nephrol 1994, 41(5):303-307.
- [16]Ibrahim HN, Ishani A, Foley RN, Guo H, Liu J, Collins AJ: Temporal trends in red blood transfusion among US dialysis patients, 1992–2005. Am J Kidney Dis 2008, 52(6):1115-1121.
- [17]US Renal Data System: USRDS 1995 Annual Data Report. Bethesda, MD: The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 1995.
- [18]Pisoni RL, Bragg-Gresham JL, Young EW, Akizawa T, Asano Y, Locatelli F, Bommer J, Cruz JM, Kerr PG, Mendelssohn DC, et al.: Anemia management and outcomes from 12 countries in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis 2004, 44(1):94-111.
- [19]Drummond MF, O’Brien B, Stoddart GL, Torrance GW: Methods for the economic-evaluation of health care programmes. New York, NY: Oxford University Press; 1997.
- [20]Gold MR, Siegel JE, Russell LB, Weinstein MC: Cost-Effectiveness in Health and Medicine. New York, NY: Oxford University Press; 1996.
- [21]Shander A, Hofmann A, Ozawa S, Theusinger OM, Gombotz H, Spahn DR: Activity-based costs of blood transfusions in surgical patients at four hospitals. Transfusion (Paris) 2010, 50(4):753-765.
- [22]Lawler EV, Bradbury BD, Fonda JR, Gaziano JM, Gagnon DR: Transfusion burden among patients with chronic kidney disease and anemia. Clin J Am Soc Nephrol 2010, 5(4):667-672.