Western Cold and Flu (WeCoF) aerosol study – preliminary results

BMC Research Notes

Samira Mubareka²  James A Scott³  Lauren R Cuthbertson¹  Matthew C Roberto¹  Karin Blackman¹  William E Lin¹  Eric Savory¹ 

[1] Department of Mechanical & Materials Engineering, The University of Western Ontario, 1151 Richmond Street North, London N6A 5B9, Canada;Department of Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto M4N 3M5, Canada;Division of Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto, 223 College Street, Toronto M5T 1R4, Canada

关键词: Bioaerosol;    Airflow sampling;    Particle Image Velocimetry;    Influenza;    Cold;    Cough;   

Others  :  1130167
DOI  :  10.1186/1756-0500-7-563

 received in 2014-03-08, accepted in 2014-08-18,  发布年份 2014

【 摘 要 】

Background

Influenza virus is responsible for annual deaths due to seasonal epidemics and is the cause of major pandemics which have claimed millions of human lives over the last century. Knowledge about respiratory virus transmission is advancing. Spread is likely through the air, but much work remains to be done to characterize the aerosols produced by infected individuals, including viral particle survival and infectivity. Although coughs have been characterized, little work has been done to examine coughs from infected individuals. The WeCoF project aims at providing evidence to support prevention measures to mitigate person-to-person influenza transmission in critical locations, such as hospitals, and during pandemics.

Findings

A novel experimental cough chamber facility – the FLUGIE – has been developed to study the far-field aerodynamics and aerosol transport of droplets produced by the coughs from humans naturally-infected with influenza. The flow field of each cough is measured using Particle Image Velocimetry (PIV). A preliminary study involving 12 healthy individuals has been carried out in order to quantify the strengths of their coughs at a distance of 1 m from the mouth. The spatially averaged maximum velocity was determined and the average value was 0.41 m/s across 27 coughs of good data quality. The peak value of velocity was also extracted and compared with the average velocity.

Conclusions

Preliminary results show that there is significant air motion associated with a cough (on the order of 0.5 m/s) as far away as 1 m from the mouth of the healthy person who coughs. The results from this pilot study provide the framework for a more extensive participant recruitment campaign that will encompass a statistically-significant cohort.

【 授权许可】

   
2014 Savory et al.; licensee BioMed Central Ltd.

【 图 表 】

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【 参考文献 】

• [1]Atkinson MP, Wein LM: Quantifying the routes of transmission for pandemic influenza. Bull Math Biol 2008, 70:820-867.
• [2]Cowling BJ, Ip DKM, Fang VJ, Suntarattiwong P, Olsen SJ, Levy J, Uyeki TM, Leung GM, Malik Peiris JS, Chotpitayasunondh T, Nishiura H, Simmerman JM: Aerosol transmission is an important mode of influenza A virus spread. Nat Commun 2013, 4:1935.
• [3]Tellier R: Aerosol transmission of influenza A virus: a review of new studies. J R Soc Interface 2009, 6:S783-S790.
• [4]Aliabadi AA, Rogak SN, Bartlett KH, Green SI: Preventing airborne disease transmission: review of methods for ventilation design in health care facilities. Adv Prev Med 2011, 124064:1-21. doi:10.4061/2011/124064
• [5]Siegel JD, Rhinehart E, Jackson M, Chiarello L: 2007 guideline for isolation precautions: Preventing transmission of infectious agents in health care settings. Am J Infect Control 2007, 35:S65-S164.
• [6]Xie X, Li Y, Chwang AT, Ho PL, Seto WH: How far droplets can move in indoor environments-revisiting the Wells evaporation-falling curve. Indoor Air 2007, 17:211-225.
• [7]Canadian Centre for Occupational Health and Safety http://www.ccohs.ca/oshanswers/chemicals/how_do.html webcite
• [8]Wainwright CE, France MW, O’Rourke P, Anuj S, Kidd TJ, Nissen MD, Sloots TP, Coulter C, Ristovski Z, Hargreaves M, Rose BR, Harbour C, Bell SC, Fennelly KP: Cough-generated aerosols of Pseudomonas aeruginosa and other Gram-negative bacteria from patients with cystic fibrosis. Thorax 2009, 64:926-931.
• [9]Knibbs LD, Johnson GR, Kidd TJ, Cheney J, Grimwood K, Kattenbelt JA, O'Rourke PK, Ramsay KA, Sly PD, Wainwright CE, Wood ME, Morawska L, Bell SC: Viability of Pseudomonas aeruginosa in cough aerosols generated by persons with cystic fibrosis. Thorax 2014, 69:740-745.
• [10]Duguid JP: The size and the duration of air-carriage of respiratory droplet and droplet-nuclei. J Hyg (Lond) 1946, 54:471-479.
• [11]Fairchild CI, Stampfer JF: Particle concentration in exhaled breath. Am Ind Hyg Assoc J 1987, 48:948-949.
• [12]Papineni RS, Rosenthal FS: The size distribution of droplets in the exhaled breath of healthy human subjects. J Aerosol Med 1997, 10:105-116.
• [13]Edwards DA, Man JC, Brand P, Katstra JP, Sommerer K, Stone HA, Nardell E, Scheuch G: Inhaling to mitigate exhaled bioaerosols. Proc Natl Acad Sci U S A 2004, 101:17383-17388.
• [14]Nicas M, Nazaroff W, Hubbard A: Toward understanding the risk of secondary airborne infection: Emission of respirable pathogens. J Occup Environ Hyg 2005, 2:143-154.
• [15]Yang S, Lee GWM, Chen CM, Wu CC, Yu KP: The size and concentration of droplets generated by coughing in human subjects. J Aerosol Med 2007, 20:484-494.
• [16]Morawska L, Johnson GR, Ristovski ZD, Hargreaves M, Mengersen K, Corbett S, Chao CYH, Li Y, Katoshevski D: Size distribution and sites of origins of droplets expelled from the human respiratory tract during expiratory activities. J Aerosol Sci 2009, 40:256-269.
• [17]Fennelly KP, Martyny JW, Fulton KE, Orme IM, Cave DM, Heifets LB: Cough generated aerosols of Mycobacterium tuberculosis: A new method to study infectiousness. Am J Respir Crit Care Med 2004, 169:604-609.
• [18]Hersen G, Moularat S, Robine E, Gehin E, Corbet S, Vabret A, Freymuth F: Impact of health on particle size of exhaled respiratory aerosols: Case– control study. CLEAN – Soil, Air, Water 2008, 36:572-577.
• [19]Chao CYH, Wan MP, Morawska L, Johnson GR, Ristovski ZD, Hargreaves M, Mengersen K, Corbett S, Li Y, Xie X, Katoshevski D: Characterization of expiration air jets and droplet size distributions immediately at the mouth opening. J Aerosol Sci 2009, 40:122-133.
• [20]Zayas G, Chiang MC, Wong E, MacDonald F, Lange CF, Senthilselvan A, King M: Cough aerosol in healthy participants: fundamental knowledge to optimize droplet-spread infectious respiratory disease management. BMC Pulm Med 2012, 12:11.
• [21]Redrow J, Mao S, Celik IJ, Posada A, Feng Z: Modeling the evaporation and dispersion of airborne sputum droplets expelled from a human cough. Build Environ 2011, 46:2042-2051.
• [22]Johnson GR, Morawska L, Ristovski ZD, Hargreaves M, Mengersen K, Chao CYH, Wan MP, Li Y, Xie X, Katoshevski D, Corbett S: Modality of human expired aerosol size distributions. J Aerosol Sci 2011, 42:839-851.
• [23]Lindsley WG, Blachere FM, Thewlis RE, Vishnu A, Davis KA, Cao G, Palmer JE, Clark KE, Fisher MA, Khakoo R, Beezhold DH: Measurements of airborne influenza virus in aerosol particles from human coughs. PLoS One 2010, 5:e15100.
• [24]Noti JD, Blachere FM, McMillen CM, Lindsley WG, Kashon ML, Slaughter DR, Beezhold DH: High humidity leads to loss of infectious influenza virus from simulated coughs. PLoS One 2013, 8:e57485.
• [25]Hemmes JH, Winkler KC, Kool SM: Virus survival as a seasonal factor in influenza and poliomyelitis. Nature 1960, 188:430-431.
• [26]Schaffer FL, Soergel ME, Straube DC: Survival of airborne influenza virus: effects of propagating host, relative humidity, and composition of spray fluids. Archives of Virology 1976, 51:263-273.
• [27]Steel J, Palese P, Lowen AC: Transmission of a 2009 pandemic influenza virus shows a sensitivity to temperature and humidity similar to that of an H3N2 seasonal strain. J Virol 2011, 85:1400.
• [28]Lowen AC, Mubareka S, Steel J, Palese P: Influenza virus transmission is dependent on relative humidity and temperature. PLoS Pathog 2007, 3:e151.
• [29]Aliabadi AA, Rogak SN, Green SI, Bartlett KH: CFD simulation of human coughs and sneezes: a study in droplet dispersion, heat, and mass transfer. In Proceedings of ASME International Mechanical Engineering Congress and Exposition (IMECE 2010): 12–18 November 2010. Vancouver, BC, Canada: American Society of Mechanical Engineers; 2010:1051-1060.
• [30]Shaman J, Kohn M, Singer BH: Absolute humidity modulates influenza survival, transmission, and seasonality. Proc Natl Acad Sci U S A 2009, 106:3243-3248.
• [31]Shaman J, Pitzer VE, Viboud C, Grenfell BT, Lipsitch M: Absolute humidity and the seasonal onset of influenza in the continental United States. PLoS Biol 2010, 8:e1000316.
• [32]Zou S, Guo J, Gao R, Dong L, Zhou J, Zhang Y, Dong J, Bo H, Qin K, Shu Y: Inactivation of the novel avian influenza A (H7N9) virus under physical conditions or chemical agents treatment. Virol J 2013, 10:289.
• [33]Vonder Haar T, Page M, Marinas B, Shisler J, Boucherie C, Heim V, David F, Recherche A: A comparative study of the inactivation of adenovirus and coxsackievirus with ultraviolet light, chlorine, and ozone. In Proceedings of the Water Quality Technology Conference and Exposition: 14–18 November 2010. Savannah, GA, USA: American Water Works Association; 2010:2926-2935.
• [34]Meng QS, Gerba CP: Comparative inactivation of enteric adenoviruses, poliovirus and coliphages by ultraviolet irradiation. Water Res 1996, 30:2665-2668.
• [35]McDevitt JJ, Lai KM, Rudnick SN, Houseman EA, First MA, Milton DK: Characterization of UVC light sensitivity of vaccinia virus. Appl Environ Microbiol 2007, 73:5760-5766.
• [36]Campbell A: The SARS Commission - Spring of Fear. In Volumes 2 and 3. Toronto: Government of Ontario; 2006:1-1204.
• [37]Leiner GC, Abramowitz S, Small MJ, Stenby VB: Cough peak flow rate. Am J Med Sci 1966, 251:211-214.
• [38]Mahajan RP, Singh P, Murty GE, Aitkenhead AR: Relationship between expired lung volume, peak flow rate and peak velocity time during a cough manoeuvre. Br J Anaesth 1994, 72:298-301.
• [39]Singh P, Mahajan RP, Murty GE, Aitkenhead AR: Relationship of peak flow rate and peak velocity time during voluntary coughing. Br J Anaesth 1995, 74:714-716.
• [40]Gupta JK, Lin CH, Chen Q: Flow dynamics and characterization of a cough. Indoor Air 2009, 19:517-525.
• [41]Jennison MW: Atomizing of mouth and nose secretions into the air as revealed by high speed photography. In Aerobiology (Publication no. 17). Edited by Moulton FR. Washington: American Association for the Advancement of Science; 1942:106-128.
• [42]Settles GS, Hackett EB, Miller JD, Weinstein LM: Full-scale Schlieren flow visualization. In Flow Visualization VII. Edited by Crowder JP. New York: Begell House; 1995:2-13.
• [43]Tang JW, Nicolle A, Pantelic J, Koh GC, Wang LD, Amin M, Klettner CA, Cheong DKW, Sekhar C, Tham KW: Airflow dynamics of coughing in healthy human volunteers by shadowgraph imaging: an aid to aerosol infection control. PLoS One 2012, 7:e34818.
• [44]Nishimura H, Sakata S, Kaga A: A new methodology for studying dynamics of aerosol particles in sneeze and cough using a digital high-vision, high-speed video system and vector analyses. PLoS One 2013, 8:e80244.
• [45]Afshari A, Azadi S, Ebeling T, Badeau A, Goldsmith WT, Weber KC, Frazer DG: Evaluation of cough using Digital Particle Image velocimetry. In Proceedings of Second Joint EMBS-BMES Conference: 23–26 October 2002. Houston: IEEE; 2002:975-976.
• [46]Badeau A, Afshari A, Goldsmith WT, Frazer D: Preliminary predictions of flow and particulate concentration produced from normal human cough dispersion. In Proceedings of Second Joint EMBS-BMES Conference: 23–26 October 2002. Houston: IEEE; 2002:246-247.
• [47]Marr D, Khan T, Glauser M, Higuchi H, Zhang J: On Particle Image Velocimetry (PIV) measurements in the breathing zone of a thermal breathing manikin. ASHRAE Trans 2005, 111:299-305.
• [48]Marr D, Spitzer IM, Glauser MN: Anisotropy in the breathing zone of a thermal manikin. Exp Fluids 2008, 44:661-673.
• [49]VanSciver M, Miller S, Hertzberg J: Particle Image Velocimetry of human cough. Aerosol Sci Technol 2011, 45:415-422.
• [50]Zhu S, Kato S, Yang JH: Investigation into airborne transport characteristics of air-flow due to coughing in a stagnant room environment. ASHRAE Trans 2006, 112:123-133.
• [51]Zhu S, Kato S, Yang JH: Study on transport characteristics of saliva droplets produced by coughing in a calm indoor environment. Build Environ 2006, 41:1691-1702.
• [52]Zhao B, Zhang Z, Li X: Numerical Study of Transport of droplets or particles generated by respiratory system indoors. Build Environ 2005, 40:1032-1039.
• [53]Kwon S-B, Park J, Jang J, Cho Y, Park D-S, Kim C, Bae G-N, Jang A: Study on the initial velocity distribution of exhaled air from coughing and speaking. Chemosphere 2012, 87:1260-1264.
• [54]Kennamer M: Basic infection control for health care providers. 2nd edition. Albany: Thomson Delmar Learning; 2007:74-78.
• [55]Bourouiba L, Dehandschoewercker E, Bush JWM: Violent expiratory events: on coughing and sneezing. J Fluid Mech 2014, 745:537-563.
• [56]Holmes NS, Morawska L: A review of dispersion modelling and its application to the dispersion of particles: an overview of different dispersion models available. Atmos Environ 2006, 40:5902-5928.
• [57]Sze To GN, Wan MP, Chao CYH, Wei F, Yu SCT, Kwan JKC: A methodology for estimating airborne virus exposures in indoor environments using the spatial distribution of expiratory aerosols and virus viability characteristics. Indoor Air 2008, 18:425-438.
• [58]Weyel DA, Ellakkani M, Alarie Y, Karol M: An aerosol generator for the resuspension of cotton dust. Toxicol Appl Pharmacol 1984, 76:544-547.