BMC Infectious Diseases | |
False positive malaria rapid diagnostic test in returning traveler with typhoid fever | |
Dylan R Pillai2  Keith Preston1  Bonnie Meatherall3  | |
[1] Calgary Laboratory Services, Calgary, AB, Canada;The University of Calgary, Diagnostic & Scientific Centre, Room 1 W-416, 9-3535 Research Road NW, Calgary, AB T2L 2 K8, Canada;Department of Medicine, University of Calgary, Calgary, AB, Canada | |
关键词: Typhoid; Rapid diagnostic test; False positive; Malaria; | |
Others : 849164 DOI : 10.1186/1471-2334-14-377 |
|
received in 2014-02-14, accepted in 2014-06-26, 发布年份 2014 | |
【 摘 要 】
Background
Rapid diagnostic tests play a pivotal role in the early diagnosis of malaria where microscopy or polymerase chain reaction are not immediately available.
Case presentation
We report the case of a 39 year old traveler to Canada who presented with fever, headache, and abdominal pain after visiting friends and relatives in India. While in India, the individual was not ill and had no signs or symptoms of malaria. Laboratory testing upon his return to Canada identified a false positive malaria rapid diagnostic (BinaxNOW® malaria) result for P. falciparum with coincident Salmonella Typhi bacteraemia without rheumatoid or autoimmune factors. Rapid diagnostic test false positivity for malaria coincided with the presence or absence of Salmonella Typhi in the blood.
Conclusions
Clinicians should be aware that Salmonella Typhi infection may result in a false positive malaria rapid diagnostic test. The mechanism of this cross-reactivity is not clear.
【 授权许可】
2014 Meatherall et al.; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
20140718091209183.pdf | 2277KB | download | |
Figure 2. | 34KB | Image | download |
Figure 1. | 243KB | Image | download |
【 图 表 】
Figure 1.
Figure 2.
【 参考文献 】
- [1]Khairnar K, Martin D, Lau R, Ralevski F, Pillai DR: Multiplex real-time quantitative PCR, microscopy and rapid diagnostic immuno-chromatographic tests for the detection of Plasmodium spp: performance, limit of detection analysis and quality assurance. Malar J 2009, 8:284. BioMed Central Full Text
- [2]m100-S23 Performance Standard for Antimicrobial Susceptibility Testing. Wayne, PA: Clinical Laboratory Standards Institute; 2013.
- [3]First Quick Test for Malaria http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm049300.htm webcite
- [4]BinaxNOW® Malaria http://www.alere.com/us/en/product-details/binaxnow-malaria.html webcite. Accessed on May 22, 2014
- [5]Schneider CA, Rasband WS, Eliceiri KW: NIH Image to ImageJ: 25 years of image analysis. Nat Methods 2012, 9:671-675.
- [6]Humar A, Ohrt C, Harrington MA, Pillai D, Kain KC: Parasight F test compared with the polymerase chain reaction and microscopy for the diagnosis of Plasmodium falciparum malaria in travelers. Am J Trop Med Hyg 1997, 56:44-48.
- [7]Iqbal J, Siddique A, Jameel M, Hira PR: Persistent histidine-rich protein 2, parasite lactate dehydrogenase, and panmalarial antigen reactivity after clearance of Plasmodium falciparum monoinfection. J Clin Microbiol 2004, 42:4237-4241.
- [8]Iqbal J, Sher A, Rab A: Plasmodium falciparum histidine-rich protein 2-based immunocapture diagnostic assay for malaria: cross-reactivity with rheumatoid factors. J Clin Microbiol 2000, 38:1184-1186.
- [9]Dimaio MA, Pereira IT, George TI, Banaei N: Performance of BinaxNOW for diagnosis of malaria in a U.S. hospital. J Clin Microbiol 2012, 50:2877-2880.
- [10]Mtove G, Hendriksen IC, Amos B, Mrema H, Mandia V, Manjurano A, Muro F, Sykes A, Hildenwall H, Whitty CJM, Reyburn H: Treatment guided by rapid diagnostic tests for malaria in Tanzanian children: safety and alternative bacterial diagnoses. Malar J 2011, 10:290. BioMed Central Full Text
- [11]Brent AJ, Oundo JO, Mwangi I, Ochola L, Lowe B, Berkley JA: Salmonella bacteraemia in Kenyan children. Pediatr Infect Dis J 2006, 25:230-236.
- [12]Schachterle SE, Mtove G, Levens JP, Clemens EG, Shi L, Raj A, Munoz B, Reller ME, West S, Dumler JS, Sullivan D: PRET Project Team: Prevalence and density-related concordance of three diagnostic tests for malaria in a region of Tanzania with hypoendemic malaria. J Clin Microbiol 2011, 49:3885-3891.